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Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant

Ashok Patel UGent and Pradeep R Vavia (2010) JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 13(2). p.114-127
abstract
Purpose: The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant. Methods: Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of the disintegrant (including sedimentation volume, hydration capacity, specific surface area and bulk and tap density) were determined and compared to the known disintegrants. Characterization was carried out using FT-IR, DSC, XRD, SEM and Photo microscopy studies. The developed excipient was also studied for acute toxicity in rats and found to be safe for oral use. Results: Disintegration property of formed product was found to give better results. As compared to known disintegrant (Ac-Di-Sol). The disintegration mechanism of developed disintegrant was postulated based on results obtained from various physical evaluations. Hausner's ratio & Carr's index value of 1.12 and 10.61 suggested excellent flowability. Wetting time and distintegration time of 21.90 +/- 0.1 and 26.20 +/- 0.2 seconds was obtained at the disintegrant level of 5 % w/w. Conclusions: By changing the condition parameters of well known crosslinking reaction of PVA, we obtained a crosslinked product which had excellent disintegration activity, good flow and optimal tableting properties.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DEFORMATION, TABLETS, MECHANISM, STARCH
journal title
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
J. Pharm. Pharm. Sci.
volume
13
issue
2
pages
114 - 127
Web of Science type
Article
Web of Science id
000279344200001
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
1.914 (2010)
JCR rank
145/249 (2010)
JCR quartile
3 (2010)
ISSN
1482-1826
language
English
UGent publication?
no
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3007959
handle
http://hdl.handle.net/1854/LU-3007959
alternative location
http://ejournals.library.ualberta.ca/index.php/JPPS/article/view/6697
date created
2012-10-05 22:56:28
date last changed
2012-10-09 15:01:05
@article{3007959,
  abstract     = {Purpose: The present study deals with evaluation of crosslinked poly vinyl alcohol (PVA) as a potential disintegrant.
Methods: Crosslinking of PVA was carried out using glutaraldehyde as a crosslinker, in presence of acidic conditions. The crosslinking reaction was optimized for a) polymer: crosslinker ratio; b) temperature requirement and c) reaction duration. Certain physical parameters of the disintegrant (including sedimentation volume, hydration capacity, specific surface area and bulk and tap density) were determined and compared to the known disintegrants. Characterization was carried out using FT-IR, DSC, XRD, SEM and Photo microscopy studies. The developed excipient was also studied for acute toxicity in rats and found to be safe for oral use.
Results: Disintegration property of formed product was found to give better results. As compared to known disintegrant (Ac-Di-Sol). The disintegration mechanism of developed disintegrant was postulated based on results obtained from various physical evaluations. Hausner's ratio \& Carr's index value of 1.12 and 10.61 suggested excellent flowability. Wetting time and distintegration time of 21.90 +/- 0.1 and 26.20 +/- 0.2 seconds was obtained at the disintegrant level of 5 \% w/w.
Conclusions: By changing the condition parameters of well known crosslinking reaction of PVA, we obtained a crosslinked product which had excellent disintegration activity, good flow and optimal tableting properties.},
  author       = {Patel, Ashok and Vavia, Pradeep R},
  issn         = {1482-1826},
  journal      = {JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES},
  keyword      = {DEFORMATION,TABLETS,MECHANISM,STARCH},
  language     = {eng},
  number       = {2},
  pages        = {114--127},
  title        = {Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant},
  url          = {http://ejournals.library.ualberta.ca/index.php/JPPS/article/view/6697},
  volume       = {13},
  year         = {2010},
}

Chicago
Patel, Ashok, and Pradeep R Vavia. 2010. “Evaluation of Synthesized Cross Linked Polyvinyl Alcohol as Potential Disintegrant.” Journal of Pharmacy and Pharmaceutical Sciences 13 (2): 114–127.
APA
Patel, A., & Vavia, P. R. (2010). Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, 13(2), 114–127.
Vancouver
1.
Patel A, Vavia PR. Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 2010;13(2):114–27.
MLA
Patel, Ashok, and Pradeep R Vavia. “Evaluation of Synthesized Cross Linked Polyvinyl Alcohol as Potential Disintegrant.” JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 13.2 (2010): 114–127. Print.