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Dried blood spots in toxicology: from the cradle to the grave?

Christophe Stove UGent, Ann-Sofie Ingels UGent, Pieter De Kesel UGent and Willy Lambert UGent (2012) CRITICAL REVIEWS IN TOXICOLOGY. 42(3). p.230-243
abstract
About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized. Perhaps best known is the use of DBS in newborn screening programs, ignited by the hallmark paper by Guthrie and Susi half a century ago. However, it is only recently that both academia and industry have recognized the many advantages that DBS sampling may offer for bioanalytical purposes, as reflected by the strong increase in published reports during the last few years. Currently, major DBS applications include newborn screening for metabolic disorders, epidemiological surveys (e. g. HIV monitoring), therapeutic drug monitoring (TDM), as well as toxicology. In this review, we provide a comprehensive overview of the distinct subdisciplines of toxicology for which DBS sampling has been applied. DBS sampling for toxicological evaluation has been performed from birth until autopsy, aiming at the assessment of therapeutic drugs, drugs of abuse, environmental contaminants, toxins, as well as (trace) elements, with applications situated in fields as toxicokinetics, epidemiology and environmental and forensic toxicology. We discuss the strengths and limitations of DBS in the different subdisciplines and provide future prospects for the use of this promising sampling technique in toxicology.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CHOLINESTERASE ACTIVITY, COLLECTION CARDS, QUANTITATIVE BIOANALYSIS, STORAGE-CONDITIONS, LARGE POPULATIONS, LEAD LEVELS, FILTER-PAPER, GAMMA-HYDROXYBUTYRIC ACID, TANDEM MASS-SPECTROMETRY, drugs of abuse, toxicokinetics, filter paper, trace elements, newborn, WHOLE-BLOOD, forensic, Toxicology, dried blood spots (DBS)
journal title
CRITICAL REVIEWS IN TOXICOLOGY
Crit. Rev. Toxicol.
volume
42
issue
3
pages
14 pages
Web of Science type
Review
Web of Science id
000300512900003
JCR category
TOXICOLOGY
JCR impact factor
6.253 (2012)
JCR rank
5/85 (2012)
JCR quartile
1 (2012)
ISSN
1040-8444
DOI
10.3109/10408444.2011.650790
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3006222
handle
http://hdl.handle.net/1854/LU-3006222
date created
2012-10-04 10:13:41
date last changed
2013-04-01 00:30:27
@article{3006222,
  abstract     = {About a century after its first described application by Ivar Bang, the potential of sampling via dried blood spots (DBS) as an alternative for classical venous blood sampling is increasingly recognized. Perhaps best known is the use of DBS in newborn screening programs, ignited by the hallmark paper by Guthrie and Susi half a century ago. However, it is only recently that both academia and industry have recognized the many advantages that DBS sampling may offer for bioanalytical purposes, as reflected by the strong increase in published reports during the last few years. Currently, major DBS applications include newborn screening for metabolic disorders, epidemiological surveys (e. g. HIV monitoring), therapeutic drug monitoring (TDM), as well as toxicology. In this review, we provide a comprehensive overview of the distinct subdisciplines of toxicology for which DBS sampling has been applied. DBS sampling for toxicological evaluation has been performed from birth until autopsy, aiming at the assessment of therapeutic drugs, drugs of abuse, environmental contaminants, toxins, as well as (trace) elements, with applications situated in fields as toxicokinetics, epidemiology and environmental and forensic toxicology. We discuss the strengths and limitations of DBS in the different subdisciplines and provide future prospects for the use of this promising sampling technique in toxicology.},
  author       = {Stove, Christophe and Ingels, Ann-Sofie and De Kesel, Pieter and Lambert, Willy},
  issn         = {1040-8444},
  journal      = {CRITICAL REVIEWS IN TOXICOLOGY},
  keyword      = {CHOLINESTERASE ACTIVITY,COLLECTION CARDS,QUANTITATIVE BIOANALYSIS,STORAGE-CONDITIONS,LARGE POPULATIONS,LEAD LEVELS,FILTER-PAPER,GAMMA-HYDROXYBUTYRIC ACID,TANDEM MASS-SPECTROMETRY,drugs of abuse,toxicokinetics,filter paper,trace elements,newborn,WHOLE-BLOOD,forensic,Toxicology,dried blood spots (DBS)},
  language     = {eng},
  number       = {3},
  pages        = {230--243},
  title        = {Dried blood spots in toxicology: from the cradle to the grave?},
  url          = {http://dx.doi.org/10.3109/10408444.2011.650790},
  volume       = {42},
  year         = {2012},
}

Chicago
Stove, Christophe, Ann-Sofie Ingels, Pieter De Kesel, and Willy Lambert. 2012. “Dried Blood Spots in Toxicology: From the Cradle to the Grave?” Critical Reviews in Toxicology 42 (3): 230–243.
APA
Stove, C., Ingels, A.-S., De Kesel, P., & Lambert, W. (2012). Dried blood spots in toxicology: from the cradle to the grave? CRITICAL REVIEWS IN TOXICOLOGY, 42(3), 230–243.
Vancouver
1.
Stove C, Ingels A-S, De Kesel P, Lambert W. Dried blood spots in toxicology: from the cradle to the grave? CRITICAL REVIEWS IN TOXICOLOGY. 2012;42(3):230–43.
MLA
Stove, Christophe, Ann-Sofie Ingels, Pieter De Kesel, et al. “Dried Blood Spots in Toxicology: From the Cradle to the Grave?” CRITICAL REVIEWS IN TOXICOLOGY 42.3 (2012): 230–243. Print.