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Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ

Celeste HM Cheung, Alexis C Wood, Yannis Paloyelis, Alejandro Arias-Vasquez, Jan K Buitelaar, Barbara Franke, Ana Miranda, Fernando Mulas, Nanda Rommelse, Joseph A Sergeant, et al. (2012) JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 53(8). p.864-873
abstract
Background: Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods: Multivariate familial models were run on data from 1,789 individuals at ages 619. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISCIII/WAISIII). Results: Significant phenotypic (.2.4) and familial (.3.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53%72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions: Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DEFICIT HYPERACTIVITY DISORDER, LEARNING-DISABILITIES, GENETIC ETIOLOGY, GENERALIST GENES, COGNITIVE DEFICITS, LONGITUDINAL TWIN, COMORBIDITY, QUESTIONNAIRE, PERFORMANCE, ADHD, reading difficulties, IQ, familial, sibling-pair, comorbidity
journal title
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
J. Child Psychol. Psychiatry
volume
53
issue
8
pages
864 - 873
Web of Science type
Article
Web of Science id
000306310200008
JCR category
PSYCHOLOGY, DEVELOPMENTAL
JCR impact factor
5.422 (2012)
JCR rank
2/65 (2012)
JCR quartile
1 (2012)
ISSN
0021-9630
DOI
10.1111/j.1469-7610.2012.02527.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3005663
handle
http://hdl.handle.net/1854/LU-3005663
date created
2012-10-03 16:47:49
date last changed
2016-12-19 15:43:05
@article{3005663,
  abstract     = {Background: Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods: Multivariate familial models were run on data from 1,789 individuals at ages 619. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISCIII/WAISIII). Results: Significant phenotypic (.2.4) and familial (.3.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53\%72\% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions: Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD.},
  author       = {Cheung, Celeste HM and Wood, Alexis C and Paloyelis, Yannis and Arias-Vasquez, Alejandro and Buitelaar, Jan K and Franke, Barbara and Miranda, Ana and Mulas, Fernando and Rommelse, Nanda and Sergeant, Joseph A and Barke, Edmund and Faraone, Stephen V and Asherson, Philip and Kuntsi, Jonna},
  issn         = {0021-9630},
  journal      = {JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY},
  keyword      = {ATTENTION-DEFICIT/HYPERACTIVITY DISORDER,DEFICIT HYPERACTIVITY DISORDER,LEARNING-DISABILITIES,GENETIC ETIOLOGY,GENERALIST GENES,COGNITIVE DEFICITS,LONGITUDINAL TWIN,COMORBIDITY,QUESTIONNAIRE,PERFORMANCE,ADHD,reading difficulties,IQ,familial,sibling-pair,comorbidity},
  language     = {eng},
  number       = {8},
  pages        = {864--873},
  title        = {Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ},
  url          = {http://dx.doi.org/10.1111/j.1469-7610.2012.02527.x},
  volume       = {53},
  year         = {2012},
}

Chicago
Cheung, Celeste HM, Alexis C Wood, Yannis Paloyelis, Alejandro Arias-Vasquez, Jan K Buitelaar, Barbara Franke, Ana Miranda, et al. 2012. “Aetiology for the Covariation Between Combined Type ADHD and Reading Difficulties in a Family Study: The Role of IQ.” Journal of Child Psychology and Psychiatry 53 (8): 864–873.
APA
Cheung, C. H., Wood, A. C., Paloyelis, Y., Arias-Vasquez, A., Buitelaar, J. K., Franke, B., Miranda, A., et al. (2012). Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 53(8), 864–873.
Vancouver
1.
Cheung CH, Wood AC, Paloyelis Y, Arias-Vasquez A, Buitelaar JK, Franke B, et al. Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY. 2012;53(8):864–73.
MLA
Cheung, Celeste HM, Alexis C Wood, Yannis Paloyelis, et al. “Aetiology for the Covariation Between Combined Type ADHD and Reading Difficulties in a Family Study: The Role of IQ.” JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 53.8 (2012): 864–873. Print.