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A role for the root cap in root branching revealed by the non-auxin probe naxillin

Bert De Rybel UGent, Dominique Audenaert UGent, Wei Xuan UGent, Paul Overvoorde, Lucia C Strader, Stefan Kepinski, Rebecca Hoye, Ronald Brisbois, Boris Parizot UGent and Steffen Vanneste UGent, et al. (2012) NATURE CHEMICAL BIOLOGY. 8(9). p.798-805
abstract
The acquisition of water and nutrients by plant roots is a fundamental aspect of agriculture and strongly depends on root architecture. Root branching and expansion of the root system is achieved through the development of lateral roots and is to a large extent controlled by the plant hormone auxin. However, the pleiotropic effects of auxin or auxin-like molecules on root systems complicate the study of lateral root development. Here we describe a small-molecule screen in Arabidopsis thaliana that identified naxillin as what is to our knowledge the first non-auxin-like molecule that promotes root branching. By using naxillin as a chemical tool, we identified a new function for root cap-specific conversion of the auxin precursor indole-3-butyric acid into the active auxin indole-3-acetic acid and uncovered the involvement of the root cap in root branching. Delivery of an auxin precursor in peripheral tissues such as the root cap might represent an important mechanism shaping root architecture.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GENE, AUX/IAA PROTEINS, PLANT DEVELOPMENT, MULTIFUNCTIONAL PROTEIN, ARABIDOPSIS-THALIANA, BOX PROTEIN TIR1, PEROXISOMAL BETA-OXIDATION, PRECURSOR INDOLE-3-BUTYRIC ACID, IDENTIFICATION, DEGRADATION
journal title
NATURE CHEMICAL BIOLOGY
Nat. Chem. Biol.
volume
8
issue
9
pages
798 - 805
Web of Science type
Article
Web of Science id
000308077600012
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
12.948 (2012)
JCR rank
9/288 (2012)
JCR quartile
1 (2012)
ISSN
1552-4450
DOI
10.1038/NCHEMBIO.1044
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3005414
handle
http://hdl.handle.net/1854/LU-3005414
date created
2012-10-03 15:01:52
date last changed
2014-05-26 10:05:02
@article{3005414,
  abstract     = {The acquisition of water and nutrients by plant roots is a fundamental aspect of agriculture and strongly depends on root architecture. Root branching and expansion of the root system is achieved through the development of lateral roots and is to a large extent controlled by the plant hormone auxin. However, the pleiotropic effects of auxin or auxin-like molecules on root systems complicate the study of lateral root development. Here we describe a small-molecule screen in Arabidopsis thaliana that identified naxillin as what is to our knowledge the first non-auxin-like molecule that promotes root branching. By using naxillin as a chemical tool, we identified a new function for root cap-specific conversion of the auxin precursor indole-3-butyric acid into the active auxin indole-3-acetic acid and uncovered the involvement of the root cap in root branching. Delivery of an auxin precursor in peripheral tissues such as the root cap might represent an important mechanism shaping root architecture.},
  author       = {De Rybel, Bert and Audenaert, Dominique and Xuan, Wei and Overvoorde, Paul and Strader, Lucia C and Kepinski, Stefan and Hoye, Rebecca and Brisbois, Ronald and Parizot, Boris and Vanneste, Steffen and Liu, Xing and Gilday, Alison and Graham, Ian A and Nguyen, Long and Jansen, Leentje and Njo, Maria and Inz{\'e}, Dirk and Bartel, Bonnie and Beeckman, Tom},
  issn         = {1552-4450},
  journal      = {NATURE CHEMICAL BIOLOGY},
  keyword      = {GENE,AUX/IAA PROTEINS,PLANT DEVELOPMENT,MULTIFUNCTIONAL PROTEIN,ARABIDOPSIS-THALIANA,BOX PROTEIN TIR1,PEROXISOMAL BETA-OXIDATION,PRECURSOR INDOLE-3-BUTYRIC ACID,IDENTIFICATION,DEGRADATION},
  language     = {eng},
  number       = {9},
  pages        = {798--805},
  title        = {A role for the root cap in root branching revealed by the non-auxin probe naxillin},
  url          = {http://dx.doi.org/10.1038/NCHEMBIO.1044},
  volume       = {8},
  year         = {2012},
}

Chicago
De Rybel, Bert, Dominique Audenaert, Wei Xuan, Paul Overvoorde, Lucia C Strader, Stefan Kepinski, Rebecca Hoye, et al. 2012. “A Role for the Root Cap in Root Branching Revealed by the Non-auxin Probe Naxillin.” Nature Chemical Biology 8 (9): 798–805.
APA
De Rybel, B., Audenaert, D., Xuan, W., Overvoorde, P., Strader, L. C., Kepinski, S., Hoye, R., et al. (2012). A role for the root cap in root branching revealed by the non-auxin probe naxillin. NATURE CHEMICAL BIOLOGY, 8(9), 798–805.
Vancouver
1.
De Rybel B, Audenaert D, Xuan W, Overvoorde P, Strader LC, Kepinski S, et al. A role for the root cap in root branching revealed by the non-auxin probe naxillin. NATURE CHEMICAL BIOLOGY. 2012;8(9):798–805.
MLA
De Rybel, Bert, Dominique Audenaert, Wei Xuan, et al. “A Role for the Root Cap in Root Branching Revealed by the Non-auxin Probe Naxillin.” NATURE CHEMICAL BIOLOGY 8.9 (2012): 798–805. Print.