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A20 inhibits NF-κB activation by dual ubiquitin-editing functions

Karen Heyninck (UGent) and Rudi Beyaert (UGent)
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Abstract
Deregulation of the transcription factor NF-kappaB can mediate several inflammatory diseases in addition to cancer. Therefore, several proteins, including the zinc finger protein A20, tightly control its activation. Recently, the underlying mechanism by which A20 downregulates NF-kappaB activation in response to the pro-inflammatory cytokine tumor necrosis factor (TNF) has been described. A20 was shown to exert two opposing activities: sequential de-ubiquitination and ubiquitination of the TNF receptor-interacting protein (RIP), thereby targeting RIP to proteasomal degradation.
Keywords
ZINC-FINGER PROTEIN, DEPENDENT GENE-EXPRESSION, CYSTEINE PROTEASES, TNF RECEPTOR, SUPERFAMILY, RECRUITMENT, APOPTOSIS, RESPONSES, PATHWAY, KINASE

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Citation

Please use this url to cite or link to this publication:

Chicago
Heyninck, Karen, and Rudi Beyaert. 2005. “A20 Inhibits NF-κB Activation by Dual Ubiquitin-editing Functions.” Trends in Biochemical Sciences 30 (1): 1–4.
APA
Heyninck, K., & Beyaert, R. (2005). A20 inhibits NF-κB activation by dual ubiquitin-editing functions. TRENDS IN BIOCHEMICAL SCIENCES, 30(1), 1–4.
Vancouver
1.
Heyninck K, Beyaert R. A20 inhibits NF-κB activation by dual ubiquitin-editing functions. TRENDS IN BIOCHEMICAL SCIENCES. 2005;30(1):1–4.
MLA
Heyninck, Karen, and Rudi Beyaert. “A20 Inhibits NF-κB Activation by Dual Ubiquitin-editing Functions.” TRENDS IN BIOCHEMICAL SCIENCES 30.1 (2005): 1–4. Print.
@article{300530,
  abstract     = {Deregulation of the transcription factor NF-kappaB can mediate several inflammatory diseases in addition to cancer. Therefore, several proteins, including the zinc finger protein A20, tightly control its activation. Recently, the underlying mechanism by which A20 downregulates NF-kappaB activation in response to the pro-inflammatory cytokine tumor necrosis factor (TNF) has been described. A20 was shown to exert two opposing activities: sequential de-ubiquitination and ubiquitination of the TNF receptor-interacting protein (RIP), thereby targeting RIP to proteasomal degradation.},
  author       = {Heyninck, Karen and Beyaert, Rudi},
  issn         = {0968-0004},
  journal      = {TRENDS IN BIOCHEMICAL SCIENCES},
  keywords     = {ZINC-FINGER PROTEIN,DEPENDENT GENE-EXPRESSION,CYSTEINE PROTEASES,TNF RECEPTOR,SUPERFAMILY,RECRUITMENT,APOPTOSIS,RESPONSES,PATHWAY,KINASE},
  language     = {eng},
  number       = {1},
  pages        = {1--4},
  title        = {A20 inhibits NF-κB activation by dual ubiquitin-editing functions},
  url          = {http://dx.doi.org/10.1016/j.tibs.2004.11.001},
  volume       = {30},
  year         = {2005},
}

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