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The effects of acute isovolemic hemodilution on oxygenation during one-lung ventilation

(2005) ANESTHESIA AND ANALGESIA. 100(1). p.15-20
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Abstract
Data on the effects of isovolemic hemodilution (IH) on oxygenation during one-lung ventilation (OLV) are lacking. We studied 47 patients with hemoglobin >14 g/dL who were scheduled for lung surgery (17 with normal lung function [group NL], 17 with chronic obstructive pulmonary disease [COPD] [group COPD], and 13 with COPD as control for time/anesthesia effects [group CTRL]). Anesthesia was standardized. The tracheas were intubated with a double-lumen tube. Ventilatory settings and fraction of inspired oxygen remained constant. The study was performed with patients in the supine position before surgery. OLV was initiated for 15 min. Two-lung ventilation was reinstituted, and IH was performed (500 mL); an identical volume of hydroxyethyl starch was administered. Subsequently, CILV was again performed for 15 min. In group CTRL, the same sequences of OLV were performed without IH. At the end of each period of OLV, pulmonary mechanics and blood gases were recorded. Data were analyzed by analysis of variance (mean +/- SD). In group NL and group CTRL, the arterial oxygen partial pressure remained constant, whereas it decreased in group COPD from 119 +/- 21 min Hg before IH to 86 +/- 16 min Hg after IH (P < 0.01). Mild IH impairs gas exchange during CILV in COPD patients, but not in patients with normal lung function.
Keywords
GAS-EXCHANGE, HYPOXIC PULMONARY VASOCONSTRICTION, BLOOD, ANESTHESIA, ATELECTASIS, MECHANISMS, ANEMIA

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Chicago
Szegedi, Laszlo L, Philippe Van der Linden, Anne Ducart, PIETER COSAERT, Jan Poelaert, Frank Vermassen, Eric Mortier, and Alain A d’ Hollander. 2005. “The Effects of Acute Isovolemic Hemodilution on Oxygenation During One-lung Ventilation.” Anesthesia and Analgesia 100 (1): 15–20.
APA
Szegedi, L. L., Van der Linden, P., Ducart, A., COSAERT, P., Poelaert, J., Vermassen, F., Mortier, E., et al. (2005). The effects of acute isovolemic hemodilution on oxygenation during one-lung ventilation. ANESTHESIA AND ANALGESIA, 100(1), 15–20.
Vancouver
1.
Szegedi LL, Van der Linden P, Ducart A, COSAERT P, Poelaert J, Vermassen F, et al. The effects of acute isovolemic hemodilution on oxygenation during one-lung ventilation. ANESTHESIA AND ANALGESIA. 2005;100(1):15–20.
MLA
Szegedi, Laszlo L, Philippe Van der Linden, Anne Ducart, et al. “The Effects of Acute Isovolemic Hemodilution on Oxygenation During One-lung Ventilation.” ANESTHESIA AND ANALGESIA 100.1 (2005): 15–20. Print.
@article{300468,
  abstract     = {Data on the effects of isovolemic hemodilution (IH) on oxygenation during one-lung ventilation (OLV) are lacking. We studied 47 patients with hemoglobin >14 g/dL who were scheduled for lung surgery (17 with normal lung function [group NL], 17 with chronic obstructive pulmonary disease [COPD] [group COPD], and 13 with COPD as control for time/anesthesia effects [group CTRL]). Anesthesia was standardized. The tracheas were intubated with a double-lumen tube. Ventilatory settings and fraction of inspired oxygen remained constant. The study was performed with patients in the supine position before surgery. OLV was initiated for 15 min. Two-lung ventilation was reinstituted, and IH was performed (500 mL); an identical volume of hydroxyethyl starch was administered. Subsequently, CILV was again performed for 15 min. In group CTRL, the same sequences of OLV were performed without IH. At the end of each period of OLV, pulmonary mechanics and blood gases were recorded. Data were analyzed by analysis of variance (mean +/- SD). In group NL and group CTRL, the arterial oxygen partial pressure remained constant, whereas it decreased in group COPD from 119 +/- 21 min Hg before IH to 86 +/- 16 min Hg after IH (P < 0.01). Mild IH impairs gas exchange during CILV in COPD patients, but not in patients with normal lung function.},
  author       = {Szegedi, Laszlo L and Van der Linden, Philippe and Ducart, Anne and COSAERT, PIETER and Poelaert, Jan and Vermassen, Frank and Mortier, Eric and d'Hollander, Alain A},
  issn         = {0003-2999},
  journal      = {ANESTHESIA AND ANALGESIA},
  keywords     = {GAS-EXCHANGE,HYPOXIC PULMONARY VASOCONSTRICTION,BLOOD,ANESTHESIA,ATELECTASIS,MECHANISMS,ANEMIA},
  language     = {eng},
  number       = {1},
  pages        = {15--20},
  title        = {The effects of acute isovolemic hemodilution on oxygenation during one-lung ventilation},
  url          = {http://dx.doi.org/10.1213/01.ANE.0000136771.64552.9C},
  volume       = {100},
  year         = {2005},
}

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