Ghent University Academic Bibliography

Advanced

Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: comparison with controlled inflammatory arthritis

RUTH WITTOEK UGent, BERT VANDER CRUYSSEN UGent and August Verbruggen UGent (2012) ARTHRITIS AND RHEUMATISM. 64(5). p.1430-1436
abstract
Objective : To compare levels of pain and functional limitation in patients with erosive osteoarthritis (OA) of the interphalangeal finger joints with those in patients with nonerosive OA and patients with controlled inflammatory arthritis affecting the hands, and to explore predictors of functional impairment in erosive OA. Methods : A cross-sectional study including 270 patients with OA of the hands who were referred to rheumatology clinics was performed. A group of patients with inflammatory arthritis (rheumatoid arthritis or psoriatic arthritis) with a low Disease Activity Score in 28 joints (<3.2; n = 79) was examined. Levels of functional impairment (measured by the Functional Index for Hand OA [FIHOA] and Australian/Canadian OA Hand Index [AUSCAN]) and pain were compared between the groups. Predictors of functional impairment in erosive OA were evaluated by generalized linear models. Results : Of 270 patients with hand OA, 167 (61.9%) were classified as having erosive OA. Despite a higher percentage of patients taking analgesics (almost 60%), patients with erosive OA had worse functional outcome and pain scores than patients with controlled inflammatory arthritis or nonerosive OA. Pain scores remained significantly higher in patients with erosive OA after correction for potential confounders. FIHOA and AUSCAN function scores showed a trend toward more disability in patients with erosive OA. Female sex and the number of radiographic affected joints (consisting of joints in the erosive and remodeled radiographic phases) were the strongest predictors of functional impairment in erosive OA. Whether the carpometacarpal joints were affected did not influence functional status in patients with erosive OA. Conclusion : Our findings indicate that patients with erosive OA have more functional impairment and significantly more pain compared to patients with controlled inflammatory arthritis affecting the hands. This highlights the significant clinical burden of erosive OA and warrants the search for new treatment strategies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RHEUMATOID-ARTHRITIS, SYMPTOMATIC HAND OSTEOARTHRITIS, CLINICAL BURDEN, DISABILITY, CLASSIFICATION, VALIDATION, CRITERIA, INDEX, ASSOCIATION, PREVALENCE
journal title
ARTHRITIS AND RHEUMATISM
Arthritis Rheum.
volume
64
issue
5
pages
1430 - 1436
Web of Science type
Article
Web of Science id
000303239000018
JCR category
RHEUMATOLOGY
JCR impact factor
7.477 (2012)
JCR rank
3/29 (2012)
JCR quartile
1 (2012)
ISSN
0004-3591
DOI
10.1002/art.33502
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3001273
handle
http://hdl.handle.net/1854/LU-3001273
date created
2012-09-28 15:41:54
date last changed
2012-10-02 12:13:06
@article{3001273,
  abstract     = {Objective : To compare levels of pain and functional limitation in patients with erosive osteoarthritis (OA) of the interphalangeal finger joints with those in patients with nonerosive OA and patients with controlled inflammatory arthritis affecting the hands, and to explore predictors of functional impairment in erosive OA.
Methods : A cross-sectional study including 270 patients with OA of the hands who were referred to rheumatology clinics was performed. A group of patients with inflammatory arthritis (rheumatoid arthritis or psoriatic arthritis) with a low Disease Activity Score in 28 joints ({\textlangle}3.2; n = 79) was examined. Levels of functional impairment (measured by the Functional Index for Hand OA [FIHOA] and Australian/Canadian OA Hand Index [AUSCAN]) and pain were compared between the groups. Predictors of functional impairment in erosive OA were evaluated by generalized linear models.
Results : Of 270 patients with hand OA, 167 (61.9\%) were classified as having erosive OA. Despite a higher percentage of patients taking analgesics (almost 60\%), patients with erosive OA had worse functional outcome and pain scores than patients with controlled inflammatory arthritis or nonerosive OA. Pain scores remained significantly higher in patients with erosive OA after correction for potential confounders. FIHOA and AUSCAN function scores showed a trend toward more disability in patients with erosive OA. Female sex and the number of radiographic affected joints (consisting of joints in the erosive and remodeled radiographic phases) were the strongest predictors of functional impairment in erosive OA. Whether the carpometacarpal joints were affected did not influence functional status in patients with erosive OA.
Conclusion : Our findings indicate that patients with erosive OA have more functional impairment and significantly more pain compared to patients with controlled inflammatory arthritis affecting the hands. This highlights the significant clinical burden of erosive OA and warrants the search for new treatment strategies.},
  author       = {WITTOEK, RUTH and VANDER CRUYSSEN, BERT and Verbruggen, August},
  issn         = {0004-3591},
  journal      = {ARTHRITIS AND RHEUMATISM},
  keyword      = {RHEUMATOID-ARTHRITIS,SYMPTOMATIC HAND OSTEOARTHRITIS,CLINICAL BURDEN,DISABILITY,CLASSIFICATION,VALIDATION,CRITERIA,INDEX,ASSOCIATION,PREVALENCE},
  language     = {eng},
  number       = {5},
  pages        = {1430--1436},
  title        = {Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: comparison with controlled inflammatory arthritis},
  url          = {http://dx.doi.org/10.1002/art.33502},
  volume       = {64},
  year         = {2012},
}

Chicago
WITTOEK, RUTH, BERT VANDER CRUYSSEN, and August Verbruggen. 2012. “Predictors of Functional Impairment and Pain in Erosive Osteoarthritis of the Interphalangeal Joints: Comparison with Controlled Inflammatory Arthritis.” Arthritis and Rheumatism 64 (5): 1430–1436.
APA
WITTOEK, R., VANDER CRUYSSEN, B., & Verbruggen, A. (2012). Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: comparison with controlled inflammatory arthritis. ARTHRITIS AND RHEUMATISM, 64(5), 1430–1436.
Vancouver
1.
WITTOEK R, VANDER CRUYSSEN B, Verbruggen A. Predictors of functional impairment and pain in erosive osteoarthritis of the interphalangeal joints: comparison with controlled inflammatory arthritis. ARTHRITIS AND RHEUMATISM. 2012;64(5):1430–6.
MLA
WITTOEK, RUTH, BERT VANDER CRUYSSEN, and August Verbruggen. “Predictors of Functional Impairment and Pain in Erosive Osteoarthritis of the Interphalangeal Joints: Comparison with Controlled Inflammatory Arthritis.” ARTHRITIS AND RHEUMATISM 64.5 (2012): 1430–1436. Print.