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Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee

AAD DHOLLANDER UGent, Peter Verdonk UGent, Stijn Lambrecht UGent, René Verdonk UGent, Dirk Elewaut UGent, August Verbruggen UGent and Karl Almqvist UGent (2012) KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 20(6). p.1118-1127
abstract
To evaluate short-term clinical and MRI outcome of the second generation characterized chondrocyte implantation (CCI) for the treatment of cartilage defects in the knee. Thirty-two patients aged 15-51 years with single International Cartilage Repair Society (ICRS) grade III/IV symptomatic cartilage defects of different locations in the knee were treated with CCI using a synthetic collagen I/III membrane to cover the defect. Clinical outcome was measured over 36 months by the Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain. Serial magnetic resonance imaging (MRI) scans of 22 patients were scored using the original and modified Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) system. The patients included in this study showed a significant gradual clinical improvement after CCI. The MRI findings of this pilot study were considered to be promising. No signs of deterioration were observed. A complete or hypertrophic filling was observed in 76.5% of the cases at 24 months of follow-up. No preventive effect of an avital membrane on the occurrence of hypertrophic repair tissue was observed on MRI. Three failures were observed among the 32 patients until now (9.4%). This investigation provided useful information on the efficacy of this treatment. The short-term clinical and MRI outcome are promising. Large-scale and long-term trials are mandatory to confirm the results and the reliability of this procedure.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Characterized, Chondrocyte, Implantation, Knee, Second, Generation, VISUAL ANALOG SCALE, ARTICULAR-CARTILAGE, AUTOLOGOUS CHONDROCYTES, REPAIR TISSUE, SCORE KOOS, TRANSPLANTATION, DEFECTS, MICROFRACTURE, RELIABILITY, INJURY
journal title
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
Knee Surg. Sports Traumatol. Arthrosc.
volume
20
issue
6
pages
1118 - 1127
Web of Science type
Article
Web of Science id
000304210900022
JCR category
SPORT SCIENCES
JCR impact factor
2.676 (2012)
JCR rank
11/84 (2012)
JCR quartile
1 (2012)
ISSN
0942-2056
DOI
10.1007/s00167-011-1759-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3001248
handle
http://hdl.handle.net/1854/LU-3001248
date created
2012-09-28 15:38:24
date last changed
2012-10-02 11:27:34
@article{3001248,
  abstract     = {To evaluate short-term clinical and MRI outcome of the second generation characterized chondrocyte implantation (CCI) for the treatment of cartilage defects in the knee. 
Thirty-two patients aged 15-51 years with single International Cartilage Repair Society (ICRS) grade III/IV symptomatic cartilage defects of different locations in the knee were treated with CCI using a synthetic collagen I/III membrane to cover the defect. Clinical outcome was measured over 36 months by the Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain. Serial magnetic resonance imaging (MRI) scans of 22 patients were scored using the original and modified Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) system. 
The patients included in this study showed a significant gradual clinical improvement after CCI. The MRI findings of this pilot study were considered to be promising. No signs of deterioration were observed. A complete or hypertrophic filling was observed in 76.5\% of the cases at 24 months of follow-up. No preventive effect of an avital membrane on the occurrence of hypertrophic repair tissue was observed on MRI. Three failures were observed among the 32 patients until now (9.4\%). 
This investigation provided useful information on the efficacy of this treatment. The short-term clinical and MRI outcome are promising. Large-scale and long-term trials are mandatory to confirm the results and the reliability of this procedure.},
  author       = {DHOLLANDER, AAD and Verdonk, Peter and Lambrecht, Stijn and Verdonk, Ren{\'e} and Elewaut, Dirk and Verbruggen, August and Almqvist, Karl},
  issn         = {0942-2056},
  journal      = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
  keyword      = {Characterized,Chondrocyte,Implantation,Knee,Second,Generation,VISUAL ANALOG SCALE,ARTICULAR-CARTILAGE,AUTOLOGOUS CHONDROCYTES,REPAIR TISSUE,SCORE KOOS,TRANSPLANTATION,DEFECTS,MICROFRACTURE,RELIABILITY,INJURY},
  language     = {eng},
  number       = {6},
  pages        = {1118--1127},
  title        = {Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee},
  url          = {http://dx.doi.org/10.1007/s00167-011-1759-7},
  volume       = {20},
  year         = {2012},
}

Chicago
DHOLLANDER, AAD, Peter Verdonk, Stijn Lambrecht, René Verdonk, Dirk Elewaut, August Verbruggen, and Karl Almqvist. 2012. “Short-term Outcome of the Second Generation Characterized Chondrocyte Implantation for the Treatment of Cartilage Lesions in the Knee.” Knee Surgery Sports Traumatology Arthroscopy 20 (6): 1118–1127.
APA
DHOLLANDER, A., Verdonk, P., Lambrecht, S., Verdonk, R., Elewaut, D., Verbruggen, A., & Almqvist, K. (2012). Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(6), 1118–1127.
Vancouver
1.
DHOLLANDER A, Verdonk P, Lambrecht S, Verdonk R, Elewaut D, Verbruggen A, et al. Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2012;20(6):1118–27.
MLA
DHOLLANDER, AAD, Peter Verdonk, Stijn Lambrecht, et al. “Short-term Outcome of the Second Generation Characterized Chondrocyte Implantation for the Treatment of Cartilage Lesions in the Knee.” KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 20.6 (2012): 1118–1127. Print.