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The combination of microfracture and a cell-free polymer-based implant immersed with autologous serum for cartilage defect coverage

Aad Dhollander UGent, Peter Verdonk UGent, Stijn Lambrecht UGent, Karl Almqvist UGent, Dirk Elewaut UGent, August Verbruggen UGent and René Verdonk UGent (2012) KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 20(9). p.1773-1780
abstract
The purpose of this short-term pilot study was to determine the clinical and MRI outcome of a combination of microfracture with a cell-free polymer-based matrix for the treatment of cartilage defects in the knee. The technique was used for treatment of symptomatic cartilage defects in the knee. Five patients were prospectively evaluated during 2 years with use of the Knee injury and Osteoarthritis Outcome Score (KOOS), the Tegner activity scale and the visual analog scale (VAS). MRI data were analyzed based on the original and modified MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) scoring system at 6, 12 and 24 months of follow-up. A gradual clinical improvement was observed during the follow-up. Adverse reactions to the matrix were not observed. The scaffold was firmly fixed with the use of bioresorbable pins. Both MOCART scoring systems revealed no significant deterioration or improvement in the repair tissue during the follow-up period. However, the majority of the patients exhibited subchondral lamina and bone changes. The formation of an intralesional osteophyte was observed in one case. The key finding in this study was that this procedure is safe for the treatment of cartilage defects in the knee. The patients showed a gradual clinical improvement postoperatively. Sixty percent (3/5) of the defects were adequately (complete or hypertrophic) filled with repair tissue at 2 years of follow-up.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Cell-free matrix, Knee, Microfracture, Cartilage defect, VISUAL ANALOG SCALE, OUTCOME SCORE KOOS, ARTICULAR-CARTILAGE, CHONDROCYTE TRANSPLANTATION, REPAIR TISSUE, KNEE INJURY, OSTEOARTHRITIS, DIFFERENTIATION, RELIABILITY, FIXATION
journal title
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
Knee Surg. Sports Traumatol. Arthrosc.
volume
20
issue
9
pages
1773 - 1780
Web of Science type
Article
Web of Science id
000307816500017
JCR category
SPORT SCIENCES
JCR impact factor
2.676 (2012)
JCR rank
11/84 (2012)
JCR quartile
1 (2012)
ISSN
0942-2056
DOI
10.1007/s00167-011-1763-y
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3001116
handle
http://hdl.handle.net/1854/LU-3001116
date created
2012-09-28 15:29:45
date last changed
2012-10-02 11:22:48
@article{3001116,
  abstract     = {The purpose of this short-term pilot study was to determine the clinical and MRI outcome of a combination of microfracture with a cell-free polymer-based matrix for the treatment of cartilage defects in the knee. 
The technique was used for treatment of symptomatic cartilage defects in the knee. Five patients were prospectively evaluated during 2 years with use of the Knee injury and Osteoarthritis Outcome Score (KOOS), the Tegner activity scale and the visual analog scale (VAS). MRI data were analyzed based on the original and modified MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) scoring system at 6, 12 and 24 months of follow-up. 
A gradual clinical improvement was observed during the follow-up. Adverse reactions to the matrix were not observed. The scaffold was firmly fixed with the use of bioresorbable pins. Both MOCART scoring systems revealed no significant deterioration or improvement in the repair tissue during the follow-up period. However, the majority of the patients exhibited subchondral lamina and bone changes. The formation of an intralesional osteophyte was observed in one case. 
The key finding in this study was that this procedure is safe for the treatment of cartilage defects in the knee. The patients showed a gradual clinical improvement postoperatively. Sixty percent (3/5) of the defects were adequately (complete or hypertrophic) filled with repair tissue at 2 years of follow-up.},
  author       = {Dhollander, Aad and Verdonk, Peter and Lambrecht, Stijn and Almqvist, Karl and Elewaut, Dirk and Verbruggen, August and Verdonk, Ren{\'e}},
  issn         = {0942-2056},
  journal      = {KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY},
  keyword      = {Cell-free matrix,Knee,Microfracture,Cartilage defect,VISUAL ANALOG SCALE,OUTCOME SCORE KOOS,ARTICULAR-CARTILAGE,CHONDROCYTE TRANSPLANTATION,REPAIR TISSUE,KNEE INJURY,OSTEOARTHRITIS,DIFFERENTIATION,RELIABILITY,FIXATION},
  language     = {eng},
  number       = {9},
  pages        = {1773--1780},
  title        = {The combination of microfracture and a cell-free polymer-based implant immersed with autologous serum for cartilage defect coverage},
  url          = {http://dx.doi.org/10.1007/s00167-011-1763-y},
  volume       = {20},
  year         = {2012},
}

Chicago
DHOLLANDER, AAD, Peter Verdonk, Stijn Lambrecht, Karl Almqvist, Dirk Elewaut, August Verbruggen, and René Verdonk. 2012. “The Combination of Microfracture and a Cell-free Polymer-based Implant Immersed with Autologous Serum for Cartilage Defect Coverage.” Knee Surgery Sports Traumatology Arthroscopy 20 (9): 1773–1780.
APA
DHOLLANDER, A., Verdonk, P., Lambrecht, S., Almqvist, K., Elewaut, D., Verbruggen, A., & Verdonk, R. (2012). The combination of microfracture and a cell-free polymer-based implant immersed with autologous serum for cartilage defect coverage. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20(9), 1773–1780.
Vancouver
1.
DHOLLANDER A, Verdonk P, Lambrecht S, Almqvist K, Elewaut D, Verbruggen A, et al. The combination of microfracture and a cell-free polymer-based implant immersed with autologous serum for cartilage defect coverage. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2012;20(9):1773–80.
MLA
DHOLLANDER, AAD, Peter Verdonk, Stijn Lambrecht, et al. “The Combination of Microfracture and a Cell-free Polymer-based Implant Immersed with Autologous Serum for Cartilage Defect Coverage.” KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 20.9 (2012): 1773–1780. Print.