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Local inflammation in chronic upper airway disease

Lien Calus UGent, Thibaut Van Zele UGent, Lara Derycke UGent, Olga Krysko UGent, Tineke Dutré UGent, PETER TOMASSEN UGent, Melissa Dullaers UGent, Claus Bachert UGent and Philippe Gevaert UGent (2012) CURRENT PHARMACEUTICAL DESIGN. 18(16). p.2336-2346
abstract
Chronic Rhinosinusitis (CRS), a chronic upper airway inflammation, is an inflammation of the nose and the paranasal cavities and is highly prevalent. Chronic rhinosinusitis is currently classified as CRS with nasal polyps or CRS without nasal polyps. This review highlights the pathophysiological differences in CRS on remodeling and on T-cell patterns. Nasal polyps have a high co-morbidity with the lower airway inflammatory disease, asthma. Evidence is accumulating for the role of superantigens, Staphylococcus aureus enterotoxins, in CRS with nasal polyps and asthma, both T helper 2-biased diseases. Until today there are no biomarkers involved in the diagnosis of CRS or the treatment follow-up. Further differentiation of the phenotype of the disease is needed, which will reflect in the development of new biomarkers and in new innovative treatment options. Defining and predicting response to therapy in individual CRS patients is a challenge for future research.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CHRONIC RHINOSINUSITIS, FC-EPSILON-RI, Chronic rhinosinusitis, asthma, treatment, inflammation, AUREUS ENTEROTOXIN-B, THYMIC STROMAL LYMPHOPOIETIN, FREE LIGHT-CHAINS, HOUSE-DUST MITE, NASAL POLYPS, OBSTRUCTIVE PULMONARY-DISEASE, ADAPTIVE IMMUNE-RESPONSES, ANTIGEN-PRESENTING CELLS
journal title
CURRENT PHARMACEUTICAL DESIGN
Curr. Pharm. Design
volume
18
issue
16
pages
2336 - 2346
Web of Science type
Review
Web of Science id
000306521200009
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
3.311 (2012)
JCR rank
65/259 (2012)
JCR quartile
2 (2012)
ISSN
1381-6128
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3000595
handle
http://hdl.handle.net/1854/LU-3000595
date created
2012-09-28 09:48:43
date last changed
2012-11-05 11:46:34
@article{3000595,
  abstract     = {Chronic Rhinosinusitis (CRS), a chronic upper airway inflammation, is an inflammation of the nose and the paranasal cavities and is highly prevalent. Chronic rhinosinusitis is currently classified as CRS with nasal polyps or CRS without nasal polyps. This review highlights the pathophysiological differences in CRS on remodeling and on T-cell patterns. Nasal polyps have a high co-morbidity with the lower airway inflammatory disease, asthma. Evidence is accumulating for the role of superantigens, Staphylococcus aureus enterotoxins, in CRS with nasal polyps and asthma, both T helper 2-biased diseases. Until today there are no biomarkers involved in the diagnosis of CRS or the treatment follow-up. Further differentiation of the phenotype of the disease is needed, which will reflect in the development of new biomarkers and in new innovative treatment options. Defining and predicting response to therapy in individual CRS patients is a challenge for future research.},
  author       = {Calus, Lien and Van Zele, Thibaut and Derycke, Lara and Krysko, Olga and Dutr{\'e}, Tineke and TOMASSEN, PETER and Dullaers, Melissa and Bachert, Claus and Gevaert, Philippe},
  issn         = {1381-6128},
  journal      = {CURRENT PHARMACEUTICAL DESIGN},
  keyword      = {CHRONIC RHINOSINUSITIS,FC-EPSILON-RI,Chronic rhinosinusitis,asthma,treatment,inflammation,AUREUS ENTEROTOXIN-B,THYMIC STROMAL LYMPHOPOIETIN,FREE LIGHT-CHAINS,HOUSE-DUST MITE,NASAL POLYPS,OBSTRUCTIVE PULMONARY-DISEASE,ADAPTIVE IMMUNE-RESPONSES,ANTIGEN-PRESENTING CELLS},
  language     = {eng},
  number       = {16},
  pages        = {2336--2346},
  title        = {Local inflammation in chronic upper airway disease},
  volume       = {18},
  year         = {2012},
}

Chicago
Calus, Lien, Thibaut Van Zele, LARA DERYCKE, Olga Krysko, Tineke Dutré, PETER TOMASSEN, Melissa Dullaers, Claus Bachert, and Philippe Gevaert. 2012. “Local Inflammation in Chronic Upper Airway Disease.” Current Pharmaceutical Design 18 (16): 2336–2346.
APA
Calus, L., Van Zele, T., DERYCKE, L., Krysko, O., Dutré, T., TOMASSEN, P., Dullaers, M., et al. (2012). Local inflammation in chronic upper airway disease. CURRENT PHARMACEUTICAL DESIGN, 18(16), 2336–2346.
Vancouver
1.
Calus L, Van Zele T, DERYCKE L, Krysko O, Dutré T, TOMASSEN P, et al. Local inflammation in chronic upper airway disease. CURRENT PHARMACEUTICAL DESIGN. 2012;18(16):2336–46.
MLA
Calus, Lien, Thibaut Van Zele, LARA DERYCKE, et al. “Local Inflammation in Chronic Upper Airway Disease.” CURRENT PHARMACEUTICAL DESIGN 18.16 (2012): 2336–2346. Print.