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Tailor-made polymers for local drug delivery: release of macromolecular model drugs from biodegradable hydrogels based on poly(ethylene oxide)

A KELNER and Etienne Schacht (2005) JOURNAL OF CONTROLLED RELEASE. 101(1-3). p.13-20
abstract
Hydrogels were synthesized from degradable and non-degradable PEO bismacromonomers. The degradability was provided by hydrolyzable segment between the main PEO chain and the methacrylate or methacrylamide groups at the both PEO chain termini. The hydrolyzable segment consisted of a monomeric alpha-hydroxy acid or a depsipeptide. The polymerization conditions and the choice of a bismacromonomer influenced the cross-linking density of the hydrogels. The release behavior of model macromolecular solutes, FITC dextran and bovine serum albumin (BSA), was studied. The small FITC-dextran 4 kDa was released rapidly front the hydrogel. The larger FITC-dextran 40 kDa and BSA were retained inside the matrix and their release rate was controlled by the degradation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (proceedingsPaper)
publication status
published
subject
journal title
JOURNAL OF CONTROLLED RELEASE
J. Control. Release
volume
101
issue
1-3
pages
13-20 pages
conference name
8th European Symposium on Controlled Drug Delivery
conference location
Noordwijk, Netherlands
conference start
2004-04-07
conference end
2004-04-09
Web of Science type
Proceedings Paper
Web of Science id
000226086800003
JCR category
CHEMISTRY, MULTIDISCIPLINARY
JCR impact factor
3.696 (2005)
JCR rank
14/123 (2005)
JCR quartile
1 (2005)
ISSN
0168-3659
DOI
10.1016/j.jconrel.2004.09.010
language
English
UGent publication?
yes
classification
A1
id
300056
handle
http://hdl.handle.net/1854/LU-300056
date created
2005-03-16 13:49:00
date last changed
2016-12-19 15:45:17
@article{300056,
  abstract     = {Hydrogels were synthesized from degradable and non-degradable PEO bismacromonomers. The degradability was provided by hydrolyzable segment between the main PEO chain and the methacrylate or methacrylamide groups at the both PEO chain termini. The hydrolyzable segment consisted of a monomeric alpha-hydroxy acid or a depsipeptide. The polymerization conditions and the choice of a bismacromonomer influenced the cross-linking density of the hydrogels. The release behavior of model macromolecular solutes, FITC dextran and bovine serum albumin (BSA), was studied. The small FITC-dextran 4 kDa was released rapidly front the hydrogel. The larger FITC-dextran 40 kDa and BSA were retained inside the matrix and their release rate was controlled by the degradation.},
  author       = {KELNER, A and Schacht, Etienne},
  issn         = {0168-3659},
  journal      = {JOURNAL OF CONTROLLED RELEASE},
  language     = {eng},
  location     = {Noordwijk, Netherlands},
  number       = {1-3},
  pages        = {13--20},
  title        = {Tailor-made polymers for local drug delivery: release of macromolecular model drugs from biodegradable hydrogels based on poly(ethylene oxide)},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2004.09.010},
  volume       = {101},
  year         = {2005},
}

Chicago
KELNER, A, and Etienne Schacht. 2005. “Tailor-made Polymers for Local Drug Delivery: Release of Macromolecular Model Drugs from Biodegradable Hydrogels Based on Poly(ethylene Oxide).” Journal of Controlled Release 101 (1-3): 13–20.
APA
KELNER, A., & Schacht, E. (2005). Tailor-made polymers for local drug delivery: release of macromolecular model drugs from biodegradable hydrogels based on poly(ethylene oxide). JOURNAL OF CONTROLLED RELEASE, 101(1-3), 13–20. Presented at the 8th European Symposium on Controlled Drug Delivery.
Vancouver
1.
KELNER A, Schacht E. Tailor-made polymers for local drug delivery: release of macromolecular model drugs from biodegradable hydrogels based on poly(ethylene oxide). JOURNAL OF CONTROLLED RELEASE. 2005;101(1-3):13–20.
MLA
KELNER, A, and Etienne Schacht. “Tailor-made Polymers for Local Drug Delivery: Release of Macromolecular Model Drugs from Biodegradable Hydrogels Based on Poly(ethylene Oxide).” JOURNAL OF CONTROLLED RELEASE 101.1-3 (2005): 13–20. Print.