Advanced search
1 file | 679.40 KB

Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis

(2012) ALLERGY. 67(11). p.1347-1356
Author
Organization
Abstract
Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.
Keywords
ARACHIDONIC-ACID, aspirin-exacerbated respiratory disease, chronic rhinosinusitis, eicosanoids, nasal polyposis, staphylococcal enterotoxins, ASPIRIN-SENSITIVE ASTHMATICS, AUREUS ENTEROTOXIN-B, NASAL POLYP TISSUE, PROSTAGLANDIN E-2, EOSINOPHILIC INFLAMMATION, INTOLERANT ASTHMA, EPITHELIAL-CELLS, IGE ANTIBODIES, REDUCED EXPRESSION

Downloads

  • Pezato Allergy ip.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 679.40 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Pezato, Rogerio, Monika Swierczyńska-Krępa, Ewa Niżankowska-Mogilnicka, Lara Derycke, Claus Bachert, and Claudina Perez Novo. 2012. “Role of Imbalance of Eicosanoid Pathways and Staphylococcal Superantigens in Chronic Rhinosinusitis.” Allergy 67 (11): 1347–1356.
APA
Pezato, R., Swierczyńska-Krępa, M., Niżankowska-Mogilnicka, E., Derycke, L., Bachert, C., & Perez Novo, C. (2012). Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis. ALLERGY, 67(11), 1347–1356.
Vancouver
1.
Pezato R, Swierczyńska-Krępa M, Niżankowska-Mogilnicka E, Derycke L, Bachert C, Perez Novo C. Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis. ALLERGY. 2012;67(11):1347–56.
MLA
Pezato, Rogerio, Monika Swierczyńska-Krępa, Ewa Niżankowska-Mogilnicka, et al. “Role of Imbalance of Eicosanoid Pathways and Staphylococcal Superantigens in Chronic Rhinosinusitis.” ALLERGY 67.11 (2012): 1347–1356. Print.
@article{3000479,
  abstract     = {Chronic rhinosinusitis (CRS) is a multifactorial disease of the upper airways with a high prevalence (approximately 11\%) in the general population. Different immune and inflammatory mechanisms are involved in its pathogenesis. Alterations in the arachidonic acid pathway (leading to an imbalanced production of eicosanoids) have been linked to the pathophysiology of different diseases especially nasal polyposis, asthma, and aspirin-exacerbated respiratory disease. Furthermore, viral and bacterial infections have been identified as important factors amplifying the pro-inflammatory reactions in these pathologies. This review summarizes the impact of an imbalance in the eicosanoid pathway and the effect of Staphylococcus aureus enterotoxins on the regulation of the pro-inflammatory network in CRS and their translation into disease severity.},
  author       = {Pezato, Rogerio and Swierczy\'{n}ska-Kr\k{e}pa, Monika and Ni\.{z}ankowska-Mogilnicka, Ewa and Derycke, Lara and Bachert, Claus and Perez Novo, Claudina},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {ARACHIDONIC-ACID,aspirin-exacerbated respiratory disease,chronic rhinosinusitis,eicosanoids,nasal polyposis,staphylococcal enterotoxins,ASPIRIN-SENSITIVE ASTHMATICS,AUREUS ENTEROTOXIN-B,NASAL POLYP TISSUE,PROSTAGLANDIN E-2,EOSINOPHILIC INFLAMMATION,INTOLERANT ASTHMA,EPITHELIAL-CELLS,IGE ANTIBODIES,REDUCED EXPRESSION},
  language     = {eng},
  number       = {11},
  pages        = {1347--1356},
  title        = {Role of imbalance of eicosanoid pathways and staphylococcal superantigens in chronic rhinosinusitis},
  url          = {http://dx.doi.org/10.1111/all.12010},
  volume       = {67},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: