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SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization

Nubia Barbosa Eloy (UGent) , Nathalie Gonzalez Sanchez (UGent) , Jelle Van Leene (UGent) , Katrien Maleux (UGent) , Hannes Vanhaeren (UGent) , Liesbeth De Milde (UGent) , Stijn Dhondt (UGent) , Leen Vercruysse (UGent) , Erwin Witters, Raphaël Mercier, et al.
(2012) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109(34). p.13853-13858
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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis.
Keywords
COMPLEX, DEPENDENT PROTEOLYSIS, LEAF DEVELOPMENT, GAMETOPHYTE DEVELOPMENT, ARABIDOPSIS-THALIANA, GENE-EXPRESSION, CELL-CYCLE, GENOME-WIDE ANALYSIS, SUBUNIT, APC/C

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Citation

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Chicago
Eloy, Nubia Barbosa, Nathalie Gonzalez Sanchez, Jelle Van Leene, Katrien Maleux, Hannes Vanhaeren, Liesbeth De Milde, Stijn Dhondt, et al. 2012. “SAMBA, a Plant-specific Anaphase-promoting Complex/cyclosome Regulator Is Involved in Early Development and A-type Cyclin Stabilization.” Proceedings of the National Academy of Sciences of the United States of America 109 (34): 13853–13858.
APA
Eloy, N. B., Gonzalez Sanchez, N., Van Leene, J., Maleux, K., Vanhaeren, H., De Milde, L., Dhondt, S., et al. (2012). SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(34), 13853–13858.
Vancouver
1.
Eloy NB, Gonzalez Sanchez N, Van Leene J, Maleux K, Vanhaeren H, De Milde L, et al. SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(34):13853–8.
MLA
Eloy, Nubia Barbosa, Nathalie Gonzalez Sanchez, Jelle Van Leene, et al. “SAMBA, a Plant-specific Anaphase-promoting Complex/cyclosome Regulator Is Involved in Early Development and A-type Cyclin Stabilization.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109.34 (2012): 13853–13858. Print.
@article{2997363,
  abstract     = {The anaphase-promoting complex/cyclosome (APC/C) is a large multiprotein E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle regulatory proteins, including the destruction of mitotic cyclins at the metaphase-to-anaphase transition. Despite its importance, the role of the APC/C in plant cells and the regulation of its activity during cell division remain poorly understood. Here, we describe the identification of a plant-specific negative regulator of the APC/C complex, designated SAMBA. In Arabidopsis thaliana, SAMBA is expressed during embryogenesis and early plant development and plays a key role in organ size control. Samba mutants produced larger seeds, leaves, and roots, which resulted from enlarged root and shoot apical meristems, and, additionally, they had a reduced fertility attributable to a hampered male gametogenesis. Inactivation of SAMBA stabilized A2-type cyclins during early development. Our data suggest that SAMBA regulates cell proliferation during early development by targeting CYCLIN A2 for APC/C-mediated proteolysis.},
  author       = {Eloy, Nubia Barbosa and Gonzalez Sanchez, Nathalie and Van Leene, Jelle and Maleux, Katrien and Vanhaeren, Hannes and De Milde, Liesbeth and Dhondt, Stijn and Vercruysse, Leen and Witters, Erwin and Mercier, Rapha{\"e}l and Cromer, Laurence and Beemster, Gerrit TS and Remaut, Han and Van Montagu, Marc and De Jaeger, Geert and Ferreira, Paulo CG and Inz{\'e}, Dirk},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  language     = {eng},
  number       = {34},
  pages        = {13853--13858},
  title        = {SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization},
  url          = {http://dx.doi.org/10.1073/pnas.1211418109},
  volume       = {109},
  year         = {2012},
}
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