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Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo

Anna Bink, Gilmer Govaert, Davy Vandenbosch UGent, Soňa Kuchariková, Tom Coenye UGent, Hans Nelis UGent, Patrick Van Dijck, Bruno PA Cammue and Karin Thevissen (2012) JOURNAL OF MEDICAL MICROBIOLOGY. 61(6). p.813-819
abstract
We investigated the molecular basis of the tolerance of Candida albicans biofilms to antifungals using the miconazole as a model compound, and translated the resulting data to other antifungals. Sessile cells of C. albicans Delta efg1, lacking the transcription factor Efg1, showed increased susceptibility to miconazole, amphotericin B and caspofungin, whereas these sessile cells were equally resistant to fluconazole. The increased sensitivity to miconazole was, at least, partly due to an increased accumulation of miconazole in the cells as compared to wild-type or reintegrant Delta efg1(EFG1) sessile cells. By using a rat biofilm model, we further confirmed the role of Efg1 in the tolerance of C. albicans biofilms to miconazole when grown in vivo.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
REGULATOR, GENE, SUSCEPTIBILITY, RAT MODEL, SIGNALING PATHWAY, SACCHAROMYCES-CEREVISIAE, MORPHOGENESIS, MICONAZOLE, ANIDULAFUNGIN, PARAPSILOSIS
journal title
JOURNAL OF MEDICAL MICROBIOLOGY
J. Med. Microbiol.
volume
61
issue
6
pages
813 - 819
Web of Science type
Article
Web of Science id
000305729700009
JCR category
MICROBIOLOGY
JCR impact factor
2.297 (2012)
JCR rank
61/116 (2012)
JCR quartile
3 (2012)
ISSN
0022-2615
DOI
10.1099/jmm.0.041020-0
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2988522
handle
http://hdl.handle.net/1854/LU-2988522
date created
2012-09-17 15:37:43
date last changed
2012-09-19 09:57:25
@article{2988522,
  abstract     = {We investigated the molecular basis of the tolerance of Candida albicans biofilms to antifungals using the miconazole as a model compound, and translated the resulting data to other antifungals. Sessile cells of C. albicans Delta efg1, lacking the transcription factor Efg1, showed increased susceptibility to miconazole, amphotericin B and caspofungin, whereas these sessile cells were equally resistant to fluconazole. The increased sensitivity to miconazole was, at least, partly due to an increased accumulation of miconazole in the cells as compared to wild-type or reintegrant Delta efg1(EFG1) sessile cells. By using a rat biofilm model, we further confirmed the role of Efg1 in the tolerance of C. albicans biofilms to miconazole when grown in vivo.},
  author       = {Bink, Anna and Govaert, Gilmer and Vandenbosch, Davy and Kucharikov{\'a}, So\v{n}a and Coenye, Tom and Nelis, Hans and Van Dijck, Patrick and Cammue, Bruno PA and Thevissen, Karin},
  issn         = {0022-2615},
  journal      = {JOURNAL OF MEDICAL MICROBIOLOGY},
  keyword      = {REGULATOR,GENE,SUSCEPTIBILITY,RAT MODEL,SIGNALING PATHWAY,SACCHAROMYCES-CEREVISIAE,MORPHOGENESIS,MICONAZOLE,ANIDULAFUNGIN,PARAPSILOSIS},
  language     = {eng},
  number       = {6},
  pages        = {813--819},
  title        = {Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo},
  url          = {http://dx.doi.org/10.1099/jmm.0.041020-0},
  volume       = {61},
  year         = {2012},
}

Chicago
Bink, Anna, Gilmer Govaert, Davy Vandenbosch, Soňa Kuchariková, Tom Coenye, Hans Nelis, Patrick Van Dijck, Bruno PA Cammue, and Karin Thevissen. 2012. “Transcription Factor Efg1 Contributes to the Tolerance of Candida Albicans Biofilms Against Antifungal Agents in Vitro and in Vivo.” Journal of Medical Microbiology 61 (6): 813–819.
APA
Bink, A., Govaert, G., Vandenbosch, D., Kuchariková, S., Coenye, T., Nelis, H., Van Dijck, P., et al. (2012). Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo. JOURNAL OF MEDICAL MICROBIOLOGY, 61(6), 813–819.
Vancouver
1.
Bink A, Govaert G, Vandenbosch D, Kuchariková S, Coenye T, Nelis H, et al. Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo. JOURNAL OF MEDICAL MICROBIOLOGY. 2012;61(6):813–9.
MLA
Bink, Anna, Gilmer Govaert, Davy Vandenbosch, et al. “Transcription Factor Efg1 Contributes to the Tolerance of Candida Albicans Biofilms Against Antifungal Agents in Vitro and in Vivo.” JOURNAL OF MEDICAL MICROBIOLOGY 61.6 (2012): 813–819. Print.