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Gene duplication and biased functional retention of paralogs in bacterial genomes

Dirk Gevers (UGent) , Klaas Vandepoele (UGent) , Cedric Simillion (UGent) and Yves Van de Peer (UGent)
(2004) TRENDS IN MICROBIOLOGY. 12(4). p.148-154
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Abstract
Gene duplication is considered an important prerequisite for gene innovation that can facilitate adaptation to changing environments. The analysis of 106 bacterial genome sequences has revealed the existence of a significant number of paralogs. Analysis of the functional classification of these paralogs reveals a preferential enrichment in functional classes that are involved in transcription, metabolism and defense mechanisms. From the organization of paralogs in the genome we can conclude that duplicated genes in bacteria appear to have been mainly created by small-scale duplication events, such as tandem and operon duplications.
Keywords
ESCHERICHIA-COLI, COMPLETE MICROBIAL GENOMES, EVOLUTION, SEQUENCE, ARABIDOPSIS, PROKARYOTES, ADAPTATION, EUKARYOTES, PHYLOGENY, ARCHAEAL

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Citation

Please use this url to cite or link to this publication:

Chicago
Gevers, Dirk, Klaas Vandepoele, Cedric Simillion, and Yves Van de Peer. 2004. “Gene Duplication and Biased Functional Retention of Paralogs in Bacterial Genomes.” Trends in Microbiology 12 (4): 148–154.
APA
Gevers, D., Vandepoele, K., Simillion, C., & Van de Peer, Y. (2004). Gene duplication and biased functional retention of paralogs in bacterial genomes. TRENDS IN MICROBIOLOGY, 12(4), 148–154.
Vancouver
1.
Gevers D, Vandepoele K, Simillion C, Van de Peer Y. Gene duplication and biased functional retention of paralogs in bacterial genomes. TRENDS IN MICROBIOLOGY. 2004;12(4):148–54.
MLA
Gevers, Dirk, Klaas Vandepoele, Cedric Simillion, et al. “Gene Duplication and Biased Functional Retention of Paralogs in Bacterial Genomes.” TRENDS IN MICROBIOLOGY 12.4 (2004): 148–154. Print.
@article{298788,
  abstract     = {Gene duplication is considered an important prerequisite for gene innovation that can facilitate adaptation to changing environments. The analysis of 106 bacterial genome sequences has revealed the existence of a significant number of paralogs. Analysis of the functional classification of these paralogs reveals a preferential enrichment in functional classes that are involved in transcription, metabolism and defense mechanisms. From the organization of paralogs in the genome we can conclude that duplicated genes in bacteria appear to have been mainly created by small-scale duplication events, such as tandem and operon duplications.},
  author       = {Gevers, Dirk and Vandepoele, Klaas and Simillion, Cedric and Van de Peer, Yves},
  issn         = {0966-842X},
  journal      = {TRENDS IN MICROBIOLOGY},
  language     = {eng},
  number       = {4},
  pages        = {148--154},
  title        = {Gene duplication and biased functional retention of paralogs in bacterial genomes},
  url          = {http://dx.doi.org/10.1016/j.tim.2004.02.007},
  volume       = {12},
  year         = {2004},
}

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