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Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Veerle Vanheusden, Hélène Munier-Lehmann, Matheus Froeyen, Roger Busson, Jef Rozenski, Piet Herdewijn and Serge Van Calenbergh UGent (2004) JOURNAL OF MEDICINAL CHEMISTRY. 47(25). p.6187-6194
abstract
Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucleoside (12), belonging to the most selective inhibitors of TMPKmt discovered so far.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ASSAY, PROGRAM, SYSTEM, MECHANISM, GENETIC ALGORITHM, THYMIDINE-5'-O-MONOPHOSPHATE ANALOGS, PYRIMIDINE NUCLEOSIDE ANALOGS, THYMIDYLATE KINASE
journal title
JOURNAL OF MEDICINAL CHEMISTRY
J. Med. Chem.
volume
47
issue
25
pages
6187 - 6194
Web of Science type
Article
Web of Science id
000225409400010
JCR category
CHEMISTRY, MEDICINAL
JCR impact factor
5.076 (2004)
JCR rank
3/36 (2004)
JCR quartile
1 (2004)
ISSN
0022-2623
DOI
10.1021/jm040847w
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
298667
handle
http://hdl.handle.net/1854/LU-298667
date created
2005-02-16 16:12:00
date last changed
2014-11-07 14:42:33
@article{298667,
  abstract     = {Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucleoside (12), belonging to the most selective inhibitors of TMPKmt discovered so far.},
  author       = {Vanheusden, Veerle and Munier-Lehmann, H{\'e}l{\`e}ne and Froeyen, Matheus and Busson, Roger and Rozenski, Jef and Herdewijn, Piet and Van Calenbergh, Serge},
  issn         = {0022-2623},
  journal      = {JOURNAL OF MEDICINAL CHEMISTRY},
  keyword      = {ASSAY,PROGRAM,SYSTEM,MECHANISM,GENETIC ALGORITHM,THYMIDINE-5'-O-MONOPHOSPHATE ANALOGS,PYRIMIDINE NUCLEOSIDE ANALOGS,THYMIDYLATE KINASE},
  language     = {eng},
  number       = {25},
  pages        = {6187--6194},
  title        = {Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase},
  url          = {http://dx.doi.org/10.1021/jm040847w},
  volume       = {47},
  year         = {2004},
}

Chicago
Vanheusden, Veerle, Hélène Munier-Lehmann, Matheus Froeyen, Roger Busson, Jef Rozenski, Piet Herdewijn, and Serge Van Calenbergh. 2004. “Discovery of Bicyclic Thymidine Analogues as Selective and High-affinity Inhibitors of Mycobacterium Tuberculosis Thymidine Monophosphate Kinase.” Journal of Medicinal Chemistry 47 (25): 6187–6194.
APA
Vanheusden, Veerle, Munier-Lehmann, H., Froeyen, M., Busson, R., Rozenski, J., Herdewijn, P., & Van Calenbergh, S. (2004). Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. JOURNAL OF MEDICINAL CHEMISTRY, 47(25), 6187–6194.
Vancouver
1.
Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, et al. Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. JOURNAL OF MEDICINAL CHEMISTRY. 2004;47(25):6187–94.
MLA
Vanheusden, Veerle, Hélène Munier-Lehmann, Matheus Froeyen, et al. “Discovery of Bicyclic Thymidine Analogues as Selective and High-affinity Inhibitors of Mycobacterium Tuberculosis Thymidine Monophosphate Kinase.” JOURNAL OF MEDICINAL CHEMISTRY 47.25 (2004): 6187–6194. Print.