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Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Monique Willart UGent, Kim Deswarte UGent, Philippe Pouliot UGent, Harald Braun UGent, Rudi Beyaert UGent, Bart Lambrecht UGent and Hamida Hammad UGent (2012) JOURNAL OF EXPERIMENTAL MEDICINE. 209(8). p.1505-1517
abstract
House dust mite (HDM) is one of the most common allergens worldwide. In this study, we have addressed the involvement of IL-1 in the interaction between HDM and the innate immune response driven by lung epithelial cells (ECs) and dendritic cells (DCs) that leads to asthma. Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, failed to mount a Th2 immune response and did not develop asthma to HDM. Experiments performed in vivo and in isolated air-liquid interface cultures of bronchial ECs showed that TLR4 signals induced the release of IL-1 alpha, which then acted in an autocrine manner to trigger the release of DC-attracting chemokines, GM-CSF, and IL-33. Consequently, allergic sensitization to HDM was abolished in vivo when IL-1 alpha, GM-CSF, or IL-33 was neutralized. Thymic stromal lymphopoietin (TSLP) became important only when high doses of allergen were administered. These findings put IL-1 alpha upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen.
Please use this url to cite or link to this publication:
author
organization
alternative title
Interleukin-1 alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
year
type
journalArticle (original)
publication status
published
subject
keyword
THYMIC STROMAL LYMPHOPOIETIN, ADAPTIVE IMMUNE-RESPONSES, DENDRITIC CELL MATURATION, NF-KAPPA-B, T-CELLS, AIRWAY INFLAMMATION, TH2 RESPONSES, SEVERE ASTHMA, IN-VIVO, MICE
journal title
JOURNAL OF EXPERIMENTAL MEDICINE
J. Exp. Med.
volume
209
issue
8
pages
1505 - 1517
Web of Science type
Article
Web of Science id
000307016500013
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
13.214 (2012)
JCR rank
3/119 (2012)
JCR quartile
1 (2012)
ISSN
0022-1007
DOI
10.1084/jem.20112691
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2986475
handle
http://hdl.handle.net/1854/LU-2986475
date created
2012-09-13 13:38:33
date last changed
2014-05-12 11:01:13
@article{2986475,
  abstract     = {House dust mite (HDM) is one of the most common allergens worldwide. In this study, we have addressed the involvement of IL-1 in the interaction between HDM and the innate immune response driven by lung epithelial cells (ECs) and dendritic cells (DCs) that leads to asthma. Mice lacking IL-1R on radioresistant cells, but not hematopoietic cells, failed to mount a Th2 immune response and did not develop asthma to HDM. Experiments performed in vivo and in isolated air-liquid interface cultures of bronchial ECs showed that TLR4 signals induced the release of IL-1 alpha, which then acted in an autocrine manner to trigger the release of DC-attracting chemokines, GM-CSF, and IL-33. Consequently, allergic sensitization to HDM was abolished in vivo when IL-1 alpha, GM-CSF, or IL-33 was neutralized. Thymic stromal lymphopoietin (TSLP) became important only when high doses of allergen were administered. These findings put IL-1 alpha upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen.},
  author       = {Willart, Monique and Deswarte, Kim and Pouliot, Philippe and Braun, Harald and Beyaert, Rudi and Lambrecht, Bart and Hammad, Hamida},
  issn         = {0022-1007},
  journal      = {JOURNAL OF EXPERIMENTAL MEDICINE},
  keyword      = {THYMIC STROMAL LYMPHOPOIETIN,ADAPTIVE IMMUNE-RESPONSES,DENDRITIC CELL MATURATION,NF-KAPPA-B,T-CELLS,AIRWAY INFLAMMATION,TH2 RESPONSES,SEVERE ASTHMA,IN-VIVO,MICE},
  language     = {eng},
  number       = {8},
  pages        = {1505--1517},
  title        = {Interleukin-1\ensuremath{\alpha} controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33},
  url          = {http://dx.doi.org/10.1084/jem.20112691},
  volume       = {209},
  year         = {2012},
}

Chicago
Willart, Monique, Kim Deswarte, Philippe Pouliot, Harald Braun, Rudi Beyaert, Bart Lambrecht, and Hamida Hammad. 2012. “Interleukin-1α Controls Allergic Sensitization to Inhaled House Dust Mite via the Epithelial Release of GM-CSF and IL-33.” Journal of Experimental Medicine 209 (8): 1505–1517.
APA
Willart, M., Deswarte, K., Pouliot, P., Braun, H., Beyaert, R., Lambrecht, B., & Hammad, H. (2012). Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. JOURNAL OF EXPERIMENTAL MEDICINE, 209(8), 1505–1517.
Vancouver
1.
Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(8):1505–17.
MLA
Willart, Monique, Kim Deswarte, Philippe Pouliot, et al. “Interleukin-1α Controls Allergic Sensitization to Inhaled House Dust Mite via the Epithelial Release of GM-CSF and IL-33.” JOURNAL OF EXPERIMENTAL MEDICINE 209.8 (2012): 1505–1517. Print.