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Vagus nerve stimulation for refractory epilepsy: a transatlantic experience

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Abstract
Vagus nerve stimulation (VNS) is an alternative treatment for medically or surgically refractory epilepsy. The long-term efficacy and safety of VNS were evaluated in a large patient series at Ghent University Hospital and Dartmouth-Hitchcock Medical Center. Between March 1995 and February 2003, seizure frequency and type as well as prescribed antiepileptic drugs and side effects were prospectively assessed in 131 patients treated with VNS in either center. Patients with a minimum follow-up duration of 6 months were included in the efficacy and safety analysis. A total of 118 of 131 implanted patients had a minimum postimplantation follow-up period of 6 months (mean, 33 months). The mean age of these patients was 32 years and the mean duration of refractory epilepsy was 22 years. The mean reduction in monthly seizure frequency in all patients was 55% (range, 0-100; SD = 31.6). Seven percent of patients were free of seizures with impaired consciousness. 50% of patients had a seizure frequency reduction of more than 50%, and 21% of patients were nonresponders. Fifteen patients reported stimulation-related side effects Such as hoarseness or gagging. In a large patient series front two geographically distinct epilepsy centers located in two different continents, VNS proved to be efficacious and safe during long-term follow-up.
Keywords
vagus nerve stimulation, refractory epilepsy, efficacy, safety, long-term, VAGAL NERVE, COMPLICATION, SEIZURES, ASYSTOLE, PATIENT, RATS, VNS

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Chicago
Vonck, Kristl, Vijay Thadani, Karen Gilbert, Stefanie Dedeurwaerdere, Liesbeth De Groote, Veerle De Herdt, Lutgard Goossens, et al. 2004. “Vagus Nerve Stimulation for Refractory Epilepsy: a Transatlantic Experience.” Journal of Clinical Neurophysiology 21 (4): 283–289.
APA
Vonck, K., Thadani, V., Gilbert, K., Dedeurwaerdere, S., De Groote, L., De Herdt, V., Goossens, L., et al. (2004). Vagus nerve stimulation for refractory epilepsy: a transatlantic experience. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 21(4), 283–289.
Vancouver
1.
Vonck K, Thadani V, Gilbert K, Dedeurwaerdere S, De Groote L, De Herdt V, et al. Vagus nerve stimulation for refractory epilepsy: a transatlantic experience. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. 2004;21(4):283–9.
MLA
Vonck, Kristl, Vijay Thadani, Karen Gilbert, et al. “Vagus Nerve Stimulation for Refractory Epilepsy: a Transatlantic Experience.” JOURNAL OF CLINICAL NEUROPHYSIOLOGY 21.4 (2004): 283–289. Print.
@article{298580,
  abstract     = {Vagus nerve stimulation (VNS) is an alternative treatment for medically or surgically refractory epilepsy. The long-term efficacy and safety of VNS were evaluated in a large patient series at Ghent University Hospital and Dartmouth-Hitchcock Medical Center. Between March 1995 and February 2003, seizure frequency and type as well as prescribed antiepileptic drugs and side effects were prospectively assessed in 131 patients treated with VNS in either center. Patients with a minimum follow-up duration of 6 months were included in the efficacy and safety analysis. A total of 118 of 131 implanted patients had a minimum postimplantation follow-up period of 6 months (mean, 33 months). The mean age of these patients was 32 years and the mean duration of refractory epilepsy was 22 years. The mean reduction in monthly seizure frequency in all patients was 55\% (range, 0-100; SD = 31.6). Seven percent of patients were free of seizures with impaired consciousness. 50\% of patients had a seizure frequency reduction of more than 50\%, and 21\% of patients were nonresponders. Fifteen patients reported stimulation-related side effects Such as hoarseness or gagging. In a large patient series front two geographically distinct epilepsy centers located in two different continents, VNS proved to be efficacious and safe during long-term follow-up.},
  author       = {Vonck, Kristl and Thadani, Vijay and Gilbert, Karen and Dedeurwaerdere, Stefanie and De Groote, Liesbeth and De Herdt, Veerle and Goossens, Lutgard and Gossiaux, Fleur and Achten, Eric and Thiery, Evert and Vingerhoets, Guy and Van Roost, Dirk and Caemaert, Jacques and De Reuck, Jacques and Robert, David and Williamson, Peter and Boon, Paul},
  issn         = {0736-0258},
  journal      = {JOURNAL OF CLINICAL NEUROPHYSIOLOGY},
  keyword      = {vagus nerve stimulation,refractory epilepsy,efficacy,safety,long-term,VAGAL NERVE,COMPLICATION,SEIZURES,ASYSTOLE,PATIENT,RATS,VNS},
  language     = {eng},
  number       = {4},
  pages        = {283--289},
  title        = {Vagus nerve stimulation for refractory epilepsy: a transatlantic experience},
  url          = {http://dx.doi.org/10.1097/01.WNP.0000139654.32974.4E},
  volume       = {21},
  year         = {2004},
}

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