Ghent University Academic Bibliography

Advanced

OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM

Laurence Cromer, Jefri Heyman UGent, Sandra Touati, Hirofumi Harashima, Emilie Araou, Chloe Girard, Christine Horlow, Katja Wassmann, Arp Schnittger and Lieven De Veylder UGent, et al. (2012) PLOS GENETICS. 8(7).
abstract
Cell cycle control is modified at meiosis compared to mitosis, because two divisions follow a single DNA replication event. Cyclin-dependent kinases (CDKs) promote progression through both meiosis and mitosis, and a central regulator of their activity is the APC/C (Anaphase Promoting Complex/Cyclosome) that is especially required for exit from mitosis. We have shown previously that OSD1 is involved in entry into both meiosis I and meiosis II in Arabidopsis thaliana; however, the molecular mechanism by which OSD1 controls these transitions has remained unclear. Here we show that OSD1 promotes meiotic progression through APC/C inhibition. Next, we explored the functional relationships between OSD1 and the genes known to control meiotic cell cycle transitions in Arabidopsis. Like osd1, cyca1;2/tam mutation leads to a premature exit from meiosis after the first division, while tdm mutants perform an aberrant third meiotic division after normal meiosis I and II. Remarkably, while tdm is epistatic to tam, osd1 is epistatic to tdm. We further show that the expression of a non-destructible CYCA1;2/TAM provokes, like tdm, the entry into a third meiotic division. Finally, we show that CYCA1;2/TAM forms an active complex with CDKA; 1 that can phosphorylate OSD1 in vitro. We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
COMPLEX/CYCLOSOME, TRANSFORMATION, EMI2, ANAPHASE, PROTEIN, PROPHASE-I, FISSION YEAST, XENOPUS-OOCYTES, MEIOSIS-II TRANSITION, ARABIDOPSIS-THALIANA
journal title
PLOS GENETICS
PLoS Genet.
volume
8
issue
7
article_number
e1002865
pages
14 pages
Web of Science type
Article
Web of Science id
000306840400057
JCR category
GENETICS & HEREDITY
JCR impact factor
8.517 (2012)
JCR rank
12/161 (2012)
JCR quartile
1 (2012)
ISSN
1553-7404
DOI
10.1371/journal.pgen.1002865
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
2985683
handle
http://hdl.handle.net/1854/LU-2985683
date created
2012-09-12 13:56:20
date last changed
2012-09-14 13:53:51
@article{2985683,
  abstract     = {Cell cycle control is modified at meiosis compared to mitosis, because two divisions follow a single DNA replication event. Cyclin-dependent kinases (CDKs) promote progression through both meiosis and mitosis, and a central regulator of their activity is the APC/C (Anaphase Promoting Complex/Cyclosome) that is especially required for exit from mitosis. We have shown previously that OSD1 is involved in entry into both meiosis I and meiosis II in Arabidopsis thaliana; however, the molecular mechanism by which OSD1 controls these transitions has remained unclear. Here we show that OSD1 promotes meiotic progression through APC/C inhibition. Next, we explored the functional relationships between OSD1 and the genes known to control meiotic cell cycle transitions in Arabidopsis. Like osd1, cyca1;2/tam mutation leads to a premature exit from meiosis after the first division, while tdm mutants perform an aberrant third meiotic division after normal meiosis I and II. Remarkably, while tdm is epistatic to tam, osd1 is epistatic to tdm. We further show that the expression of a non-destructible CYCA1;2/TAM provokes, like tdm, the entry into a third meiotic division. Finally, we show that CYCA1;2/TAM forms an active complex with CDKA; 1 that can phosphorylate OSD1 in vitro. We thus propose that a functional network composed of OSD1, CYCA1;2/TAM, and TDM controls three key steps of meiotic progression, in which OSD1 is a meiotic APC/C inhibitor.},
  articleno    = {e1002865},
  author       = {Cromer, Laurence and Heyman, Jefri and Touati, Sandra and Harashima, Hirofumi and Araou, Emilie and Girard, Chloe and Horlow, Christine and Wassmann, Katja and Schnittger, Arp and De Veylder, Lieven and Mercier, Raphael},
  issn         = {1553-7404},
  journal      = {PLOS GENETICS},
  keyword      = {COMPLEX/CYCLOSOME,TRANSFORMATION,EMI2,ANAPHASE,PROTEIN,PROPHASE-I,FISSION YEAST,XENOPUS-OOCYTES,MEIOSIS-II TRANSITION,ARABIDOPSIS-THALIANA},
  language     = {eng},
  number       = {7},
  pages        = {14},
  title        = {OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM},
  url          = {http://dx.doi.org/10.1371/journal.pgen.1002865},
  volume       = {8},
  year         = {2012},
}

Chicago
Cromer, Laurence, Jefri Heyman, Sandra Touati, Hirofumi Harashima, Emilie Araou, Chloe Girard, Christine Horlow, et al. 2012. “OSD1 Promotes Meiotic Progression via APC/C Inhibition and Forms a Regulatory Network with TDM and CYCA1;2/TAM.” Plos Genetics 8 (7).
APA
Cromer, L., Heyman, J., Touati, S., Harashima, H., Araou, E., Girard, C., Horlow, C., et al. (2012). OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM. PLOS GENETICS, 8(7).
Vancouver
1.
Cromer L, Heyman J, Touati S, Harashima H, Araou E, Girard C, et al. OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM. PLOS GENETICS. 2012;8(7).
MLA
Cromer, Laurence, Jefri Heyman, Sandra Touati, et al. “OSD1 Promotes Meiotic Progression via APC/C Inhibition and Forms a Regulatory Network with TDM and CYCA1;2/TAM.” PLOS GENETICS 8.7 (2012): n. pag. Print.