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5,5'-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors

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Abstract
We report the synthesis of 5'-modified and 5,5'-modified thymidine analogues as TMPKmt inhibitors. 5'-Substituents involving (methylsulfonyl)methyl, (Nmethylsulfamoyl) methyl, cyanomethyl, (1H-tetrazol-5-yl)methyl were combined with a 5-methyl or a 5-hydroxymethyl group at the pyrimidine moiety. The successful synthesis of the bis-substituted analogues will be discussed as well as the capacity of the target analogues to inhibit TMPKmt.

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Chicago
Toti, Kiran, Frederick Verbeke, Martijn Risseeuw, Hélène Munier-Lehmann, and Serge Van Calenbergh. 2012. “5,5’-Bis-substituted 2'-deoxyuridines as Possible M. Tuberculosis Thymidylate Kinase Inhibitors.” In Nucleosides, Nucleotides and Nucleic Acids, 20th International Roundtable, Abstracts, 52–52. International Society of Nucleosides, Nucleotides and Nucleic Acids (IS3NA).
APA
Toti, K., Verbeke, F., Risseeuw, M., Munier-Lehmann, H., & Van Calenbergh, S. (2012). 5,5’-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors. Nucleosides, Nucleotides and Nucleic Acids, 20th International roundtable, Abstracts (pp. 52–52). Presented at the 20th International roundtable on Nucleosides, Nucleotides and Nucleic Acids, International Society of Nucleosides, Nucleotides and Nucleic Acids (IS3NA).
Vancouver
1.
Toti K, Verbeke F, Risseeuw M, Munier-Lehmann H, Van Calenbergh S. 5,5’-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors. Nucleosides, Nucleotides and Nucleic Acids, 20th International roundtable, Abstracts. International Society of Nucleosides, Nucleotides and Nucleic Acids (IS3NA); 2012. p. 52–52.
MLA
Toti, Kiran, Frederick Verbeke, Martijn Risseeuw, et al. “5,5’-Bis-substituted 2'-deoxyuridines as Possible M. Tuberculosis Thymidylate Kinase Inhibitors.” Nucleosides, Nucleotides and Nucleic Acids, 20th International Roundtable, Abstracts. International Society of Nucleosides, Nucleotides and Nucleic Acids (IS3NA), 2012. 52–52. Print.
@inproceedings{2984062,
  abstract     = {We report the synthesis of 5'-modified and 5,5'-modified thymidine analogues as TMPKmt inhibitors. 5'-Substituents involving (methylsulfonyl)methyl, (Nmethylsulfamoyl) methyl, cyanomethyl, (1H-tetrazol-5-yl)methyl were combined with a 5-methyl or a 5-hydroxymethyl group at the pyrimidine moiety. The successful synthesis of the bis-substituted analogues will be discussed as well as the capacity of the target analogues to inhibit TMPKmt.},
  author       = {Toti, Kiran and Verbeke, Frederick and Risseeuw, Martijn and Munier-Lehmann, H{\'e}l{\`e}ne and Van Calenbergh, Serge},
  booktitle    = {Nucleosides, Nucleotides and Nucleic Acids, 20th International roundtable, Abstracts},
  language     = {eng},
  location     = {Montr{\'e}al, QU, Canada},
  pages        = {52--52},
  publisher    = {International Society of Nucleosides, Nucleotides and Nucleic Acids (IS3NA)},
  title        = {5,5'-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors},
  year         = {2012},
}