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Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers

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Abstract
Three-arm (A(2)B) and four-arm (A(2)B(2)) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(epsilon-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an omega-azide terminated PEO chains with PCL chain bearing one (A(2)B) or two (A(2)B(2)) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure.
Keywords
SURFACES, SYSTEMS, GENERATION, NANOPARTICLES, DRUG CARRIERS, ALIPHATIC POLYESTERS, POLYMERIC MICELLES, star polymers, nanoparticles, micelles, amphiphilic polymers, aliphatic polyesters

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MLA
Cajot, Sebastien, Raphael Riva, Leen Billiet, et al. “Novel Amphiphilic Mikto-arm Star-shaped Copolymers for the Preparation of PLA-based Nanocarriers.” Macromolecular Symposia. Ed. A Lendlein & DW Grijpma. Vol. 309–310. Weinheim, Germany: Wiley-VCH, 2011. 111–122. Print.
APA
Cajot, S., Riva, R., Billiet, L., Du Prez, F., Alexandre, M., Lecomte, P., & Jérôme, C. (2011). Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers. In A Lendlein & D. Grijpma (Eds.), Macromolecular Symposia (Vol. 309–310, pp. 111–122). Presented at the Conference on Advanced Functional Polymers for Medicine (AFPM), Weinheim, Germany: Wiley-VCH.
Chicago author-date
Cajot, Sebastien, Raphael Riva, Leen Billiet, Filip Du Prez, Michaël Alexandre, Philippe Lecomte, and Christine Jérôme. 2011. “Novel Amphiphilic Mikto-arm Star-shaped Copolymers for the Preparation of PLA-based Nanocarriers.” In Macromolecular Symposia, ed. A Lendlein and DW Grijpma, 309-310:111–122. Weinheim, Germany: Wiley-VCH.
Chicago author-date (all authors)
Cajot, Sebastien, Raphael Riva, Leen Billiet, Filip Du Prez, Michaël Alexandre, Philippe Lecomte, and Christine Jérôme. 2011. “Novel Amphiphilic Mikto-arm Star-shaped Copolymers for the Preparation of PLA-based Nanocarriers.” In Macromolecular Symposia, ed. A Lendlein and DW Grijpma, 309-310:111–122. Weinheim, Germany: Wiley-VCH.
Vancouver
1.
Cajot S, Riva R, Billiet L, Du Prez F, Alexandre M, Lecomte P, et al. Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers. In: Lendlein A, Grijpma D, editors. Macromolecular Symposia. Weinheim, Germany: Wiley-VCH; 2011. p. 111–22.
IEEE
[1]
S. Cajot et al., “Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers,” in Macromolecular Symposia, Enschede, The Netherlands, 2011, vol. 309–310, pp. 111–122.
@inproceedings{2979953,
  abstract     = {Three-arm (A(2)B) and four-arm (A(2)B(2)) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(epsilon-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an omega-azide terminated PEO chains with PCL chain bearing one (A(2)B) or two (A(2)B(2)) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure.},
  author       = {Cajot, Sebastien and Riva, Raphael and Billiet, Leen and Du Prez, Filip and Alexandre, Michaël and Lecomte, Philippe and Jérôme, Christine},
  booktitle    = {Macromolecular Symposia},
  editor       = {Lendlein, A and Grijpma, DW},
  issn         = {1022-1360},
  keywords     = {SURFACES,SYSTEMS,GENERATION,NANOPARTICLES,DRUG CARRIERS,ALIPHATIC POLYESTERS,POLYMERIC MICELLES,star polymers,nanoparticles,micelles,amphiphilic polymers,aliphatic polyesters},
  language     = {eng},
  location     = {Enschede, The Netherlands},
  pages        = {111--122},
  publisher    = {Wiley-VCH},
  title        = {Novel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers},
  url          = {http://dx.doi.org/10.1002/masy.201100044},
  volume       = {309-310},
  year         = {2011},
}

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