Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering
(2012) MACROMOLECULAR BIOSCIENCE. 12(3). p.383-394- abstract
- A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-2978391
- author
- Tuğba Dışpınar UGent, Wim Van Camp UGent, Liesbeth De Cock, Bruno De Geest UGent and Filip Du Prez UGent
- organization
- year
- 2012
- type
- journalArticle (original)
- publication status
- published
- subject
- keyword
- michael addition, stimuli-sensitive polymers, hydrogels, cryogels, tissue engineering, CROSS-LINKING, RADICAL POLYMERIZATION, BIS(ACETYLENE KETONE)S, TELECHELIC OLIGOMERS, CONJUGATE ADDITION, MICHAEL ADDITIONS, CHAIN EXTENSION, HYDROGELS, BISMALEIMIDES, DISULFIDE
- journal title
- MACROMOLECULAR BIOSCIENCE
- Macromol. Biosci.
- volume
- 12
- issue
- 3
- pages
- 383 - 394
- Web of Science type
- Article
- Web of Science id
- 000301052700010
- JCR category
- POLYMER SCIENCE
- JCR impact factor
- 3.742 (2012)
- JCR rank
- 9/82 (2012)
- JCR quartile
- 1 (2012)
- ISSN
- 1616-5187
- DOI
- 10.1002/mabi.201100396
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have transferred the copyright for this publication to the publisher
- id
- 2978391
- handle
- http://hdl.handle.net/1854/LU-2978391
- date created
- 2012-09-04 14:19:34
- date last changed
- 2012-09-06 15:57:26
@article{2978391,
abstract = {A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95\%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering},
author = {D{\i}\c{s}p{\i}nar, Tu\u{g}ba and Van Camp, Wim and De Cock, Liesbeth and De Geest, Bruno and Du Prez, Filip},
issn = {1616-5187},
journal = {MACROMOLECULAR BIOSCIENCE},
keyword = {michael addition,stimuli-sensitive polymers,hydrogels,cryogels,tissue engineering,CROSS-LINKING,RADICAL POLYMERIZATION,BIS(ACETYLENE KETONE)S,TELECHELIC OLIGOMERS,CONJUGATE ADDITION,MICHAEL ADDITIONS,CHAIN EXTENSION,HYDROGELS,BISMALEIMIDES,DISULFIDE},
language = {eng},
number = {3},
pages = {383--394},
title = {Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering},
url = {http://dx.doi.org/10.1002/mabi.201100396},
volume = {12},
year = {2012},
}
- Chicago
- Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” Macromolecular Bioscience 12 (3): 383–394.
- APA
- Dışpınar, T., Van Camp, W., De Cock, L., De Geest, B., & Du Prez, F. (2012). Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE, 12(3), 383–394.
- Vancouver
- 1.Dışpınar T, Van Camp W, De Cock L, De Geest B, Du Prez F. Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE. 2012;12(3):383–94.
- MLA
- Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, et al. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE 12.3 (2012): 383–394. Print.