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Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering

Tuğba Dışpınar (UGent) , Wim Van Camp (UGent) , Liesbeth De Cock, Bruno De Geest (UGent) and Filip Du Prez (UGent)
(2012) MACROMOLECULAR BIOSCIENCE. 12(3). p.383-394
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Abstract
A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering
Keywords
michael addition, stimuli-sensitive polymers, hydrogels, cryogels, tissue engineering, CROSS-LINKING, RADICAL POLYMERIZATION, BIS(ACETYLENE KETONE)S, TELECHELIC OLIGOMERS, CONJUGATE ADDITION, MICHAEL ADDITIONS, CHAIN EXTENSION, HYDROGELS, BISMALEIMIDES, DISULFIDE

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Citation

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MLA
Dışpınar, Tuğba et al. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE 12.3 (2012): 383–394. Print.
APA
Dışpınar, T., Van Camp, W., De Cock, L., De Geest, B., & Du Prez, F. (2012). Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE, 12(3), 383–394.
Chicago author-date
Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” Macromolecular Bioscience 12 (3): 383–394.
Chicago author-date (all authors)
Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” Macromolecular Bioscience 12 (3): 383–394.
Vancouver
1.
Dışpınar T, Van Camp W, De Cock L, De Geest B, Du Prez F. Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE. 2012;12(3):383–94.
IEEE
[1]
T. Dışpınar, W. Van Camp, L. De Cock, B. De Geest, and F. Du Prez, “Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering,” MACROMOLECULAR BIOSCIENCE, vol. 12, no. 3, pp. 383–394, 2012.
@article{2978391,
  abstract     = {A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering},
  author       = {Dışpınar, Tuğba and Van Camp, Wim and De Cock, Liesbeth and De Geest, Bruno and Du Prez, Filip},
  issn         = {1616-5187},
  journal      = {MACROMOLECULAR BIOSCIENCE},
  keywords     = {michael addition,stimuli-sensitive polymers,hydrogels,cryogels,tissue engineering,CROSS-LINKING,RADICAL POLYMERIZATION,BIS(ACETYLENE KETONE)S,TELECHELIC OLIGOMERS,CONJUGATE ADDITION,MICHAEL ADDITIONS,CHAIN EXTENSION,HYDROGELS,BISMALEIMIDES,DISULFIDE},
  language     = {eng},
  number       = {3},
  pages        = {383--394},
  title        = {Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering},
  url          = {http://dx.doi.org/10.1002/mabi.201100396},
  volume       = {12},
  year         = {2012},
}
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