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Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering

Tuğba Dışpınar UGent, Wim Van Camp UGent, Liesbeth De Cock, Bruno De Geest UGent and Filip Du Prez UGent (2012) MACROMOLECULAR BIOSCIENCE. 12(3). p.383-394
abstract
A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
michael addition, stimuli-sensitive polymers, hydrogels, cryogels, tissue engineering, CROSS-LINKING, RADICAL POLYMERIZATION, BIS(ACETYLENE KETONE)S, TELECHELIC OLIGOMERS, CONJUGATE ADDITION, MICHAEL ADDITIONS, CHAIN EXTENSION, HYDROGELS, BISMALEIMIDES, DISULFIDE
journal title
MACROMOLECULAR BIOSCIENCE
Macromol. Biosci.
volume
12
issue
3
pages
383 - 394
Web of Science type
Article
Web of Science id
000301052700010
JCR category
POLYMER SCIENCE
JCR impact factor
3.742 (2012)
JCR rank
9/82 (2012)
JCR quartile
1 (2012)
ISSN
1616-5187
DOI
10.1002/mabi.201100396
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2978391
handle
http://hdl.handle.net/1854/LU-2978391
date created
2012-09-04 14:19:34
date last changed
2012-09-06 15:57:26
@article{2978391,
  abstract     = {A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95\%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering},
  author       = {D{\i}\c{s}p{\i}nar, Tu\u{g}ba and Van Camp, Wim and De Cock, Liesbeth and De Geest, Bruno and Du Prez, Filip},
  issn         = {1616-5187},
  journal      = {MACROMOLECULAR BIOSCIENCE},
  keyword      = {michael addition,stimuli-sensitive polymers,hydrogels,cryogels,tissue engineering,CROSS-LINKING,RADICAL POLYMERIZATION,BIS(ACETYLENE KETONE)S,TELECHELIC OLIGOMERS,CONJUGATE ADDITION,MICHAEL ADDITIONS,CHAIN EXTENSION,HYDROGELS,BISMALEIMIDES,DISULFIDE},
  language     = {eng},
  number       = {3},
  pages        = {383--394},
  title        = {Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering},
  url          = {http://dx.doi.org/10.1002/mabi.201100396},
  volume       = {12},
  year         = {2012},
}

Chicago
Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” Macromolecular Bioscience 12 (3): 383–394.
APA
Dışpınar, T., Van Camp, W., De Cock, L., De Geest, B., & Du Prez, F. (2012). Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE, 12(3), 383–394.
Vancouver
1.
Dışpınar T, Van Camp W, De Cock L, De Geest B, Du Prez F. Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE. 2012;12(3):383–94.
MLA
Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, et al. “Redox-responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE 12.3 (2012): 383–394. Print.