Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering
- Author
- Tuğba Dışpınar (UGent) , Wim Van Camp (UGent) , Liesbeth De Cock, Bruno De Geest (UGent) and Filip Du Prez (UGent)
- Organization
- Abstract
- A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering
- Keywords
- michael addition, stimuli-sensitive polymers, hydrogels, cryogels, tissue engineering, CROSS-LINKING, RADICAL POLYMERIZATION, BIS(ACETYLENE KETONE)S, TELECHELIC OLIGOMERS, CONJUGATE ADDITION, MICHAEL ADDITIONS, CHAIN EXTENSION, HYDROGELS, BISMALEIMIDES, DISULFIDE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-2978391
- MLA
- Dışpınar, Tuğba, et al. “Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE, vol. 12, no. 3, 2012, pp. 383–94, doi:10.1002/mabi.201100396.
- APA
- Dışpınar, T., Van Camp, W., De Cock, L., De Geest, B., & Du Prez, F. (2012). Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE, 12(3), 383–394. https://doi.org/10.1002/mabi.201100396
- Chicago author-date
- Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE 12 (3): 383–94. https://doi.org/10.1002/mabi.201100396.
- Chicago author-date (all authors)
- Dışpınar, Tuğba, Wim Van Camp, Liesbeth De Cock, Bruno De Geest, and Filip Du Prez. 2012. “Redox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue Engineering.” MACROMOLECULAR BIOSCIENCE 12 (3): 383–394. doi:10.1002/mabi.201100396.
- Vancouver
- 1.Dışpınar T, Van Camp W, De Cock L, De Geest B, Du Prez F. Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering. MACROMOLECULAR BIOSCIENCE. 2012;12(3):383–94.
- IEEE
- [1]T. Dışpınar, W. Van Camp, L. De Cock, B. De Geest, and F. Du Prez, “Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering,” MACROMOLECULAR BIOSCIENCE, vol. 12, no. 3, pp. 383–394, 2012.
@article{2978391,
abstract = {{A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering}},
author = {{Dışpınar, Tuğba and Van Camp, Wim and De Cock, Liesbeth and De Geest, Bruno and Du Prez, Filip}},
issn = {{1616-5187}},
journal = {{MACROMOLECULAR BIOSCIENCE}},
keywords = {{michael addition,stimuli-sensitive polymers,hydrogels,cryogels,tissue engineering,CROSS-LINKING,RADICAL POLYMERIZATION,BIS(ACETYLENE KETONE)S,TELECHELIC OLIGOMERS,CONJUGATE ADDITION,MICHAEL ADDITIONS,CHAIN EXTENSION,HYDROGELS,BISMALEIMIDES,DISULFIDE}},
language = {{eng}},
number = {{3}},
pages = {{383--394}},
title = {{Redox-responsive degradable PEG cryogels as potential cell scaffolds in tissue engineering}},
url = {{http://dx.doi.org/10.1002/mabi.201100396}},
volume = {{12}},
year = {{2012}},
}
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