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ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots

Xu Chen (UGent), Satoshi Naramoto, Stephanie Robert (UGent), Ricardo Tejos Ulloa (UGent), Christian Löfke, Deshu Lin, Zhenbiao Yang and Jiri Friml
(2012) CURRENT BIOLOGY. 22(14). p.1326-1332
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Abstract
The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin ABP1 ROP6/RIC1 clathrin PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development.
Keywords
PLANT-CELLS, CARRIER, PLASMA-MEMBRANE, EXPRESSION, DYNAMICS, PIN2, POLARITY, TRANSPORT, AUXIN-EFFLUX

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Chicago
Chen, Xu, Satoshi Naramoto, Stephanie Robert, Ricardo Tejos Ulloa, Christian Löfke, Deshu Lin, Zhenbiao Yang, and Jiri Friml. 2012. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin-mediated Endocytosis in Arabidopsis Roots.” Current Biology 22 (14): 1326–1332.
APA
Chen, Xu, Naramoto, S., Robert, S., Tejos Ulloa, R., Löfke, C., Lin, D., Yang, Z., et al. (2012). ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots. CURRENT BIOLOGY, 22(14), 1326–1332.
Vancouver
1.
Chen X, Naramoto S, Robert S, Tejos Ulloa R, Löfke C, Lin D, et al. ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots. CURRENT BIOLOGY. 2012;22(14):1326–32.
MLA
Chen, Xu, Satoshi Naramoto, Stephanie Robert, et al. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin-mediated Endocytosis in Arabidopsis Roots.” CURRENT BIOLOGY 22.14 (2012): 1326–1332. Print.
@article{2976890,
  abstract     = {The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin ABP1 ROP6/RIC1 clathrin PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development.},
  author       = {Chen, Xu and Naramoto, Satoshi and Robert, Stephanie and Tejos Ulloa, Ricardo and L{\"o}fke, Christian and Lin, Deshu and Yang, Zhenbiao and Friml, Jiri},
  issn         = {0960-9822},
  journal      = {CURRENT BIOLOGY},
  keyword      = {PLANT-CELLS,CARRIER,PLASMA-MEMBRANE,EXPRESSION,DYNAMICS,PIN2,POLARITY,TRANSPORT,AUXIN-EFFLUX},
  language     = {eng},
  number       = {14},
  pages        = {1326--1332},
  title        = {ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots},
  url          = {http://dx.doi.org/10.1016/j.cub.2012.05.020},
  volume       = {22},
  year         = {2012},
}
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