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ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots

Xu Chen (UGent) , Satoshi Naramoto, Stephanie Robert (UGent) , Ricardo Tejos Ulloa (UGent) , Christian Löfke, Deshu Lin, Zhenbiao Yang and Jiri Friml (UGent)
(2012) CURRENT BIOLOGY. 22(14). p.1326-1332
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Abstract
The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin ABP1 ROP6/RIC1 clathrin PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development.
Keywords
PLANT-CELLS, CARRIER, PLASMA-MEMBRANE, EXPRESSION, DYNAMICS, PIN2, POLARITY, TRANSPORT, AUXIN-EFFLUX

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MLA
Chen, Xu, Satoshi Naramoto, Stephanie Robert, et al. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin-mediated Endocytosis in Arabidopsis Roots.” CURRENT BIOLOGY 22.14 (2012): 1326–1332. Print.
APA
Chen, Xu, Naramoto, S., Robert, S., Tejos Ulloa, R., Löfke, C., Lin, D., Yang, Z., et al. (2012). ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots. CURRENT BIOLOGY, 22(14), 1326–1332.
Chicago author-date
Chen, Xu, Satoshi Naramoto, Stephanie Robert, Ricardo Tejos Ulloa, Christian Löfke, Deshu Lin, Zhenbiao Yang, and Jiri Friml. 2012. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin-mediated Endocytosis in Arabidopsis Roots.” Current Biology 22 (14): 1326–1332.
Chicago author-date (all authors)
Chen, Xu, Satoshi Naramoto, Stephanie Robert, Ricardo Tejos Ulloa, Christian Löfke, Deshu Lin, Zhenbiao Yang, and Jiri Friml. 2012. “ABP1 and ROP6 GTPase Signaling Regulate Clathrin-mediated Endocytosis in Arabidopsis Roots.” Current Biology 22 (14): 1326–1332.
Vancouver
1.
Chen X, Naramoto S, Robert S, Tejos Ulloa R, Löfke C, Lin D, et al. ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots. CURRENT BIOLOGY. 2012;22(14):1326–32.
IEEE
[1]
X. Chen et al., “ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots,” CURRENT BIOLOGY, vol. 22, no. 14, pp. 1326–1332, 2012.
@article{2976890,
  abstract     = {The dynamic spatial and temporal distribution of the crucial plant signaling molecule auxin is achieved by feedback coordination of auxin signaling and intercellular auxin transport pathways [1, 2]. Developmental roles of auxin have been attributed predominantly to its effect on transcription; however, an alternative pathway involving AUXIN BINDING PROTEIN1 (ABP1) has been proposed to regulate clathrin-mediated endocytosis in roots and Rho-like GTPase (ROP)-dependent pavement cell interdigitation in leaves [3, 4]. In this study, we show that ROP6 and its downstream effector RIC1 regulate clathrin association with the plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analysis revealed that ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis. This signaling circuit is also involved in the feedback regulation of PIN-FORMED 1 (PIN1) and PIN2 auxin transporters activity (via its constitutive endocytosis) and corresponding auxin transport-mediated processes, including root gravitropism and leave vascular tissue patterning. Our findings suggest that the signaling module auxin ABP1 ROP6/RIC1 clathrin PIN1/PIN2 is a shared component of the feedback regulation of auxin transport during both root and aerial development.},
  author       = {Chen, Xu and Naramoto, Satoshi and Robert, Stephanie and Tejos Ulloa, Ricardo and Löfke, Christian and Lin, Deshu and Yang, Zhenbiao and Friml, Jiri},
  issn         = {0960-9822},
  journal      = {CURRENT BIOLOGY},
  keywords     = {PLANT-CELLS,CARRIER,PLASMA-MEMBRANE,EXPRESSION,DYNAMICS,PIN2,POLARITY,TRANSPORT,AUXIN-EFFLUX},
  language     = {eng},
  number       = {14},
  pages        = {1326--1332},
  title        = {ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots},
  url          = {http://dx.doi.org/10.1016/j.cub.2012.05.020},
  volume       = {22},
  year         = {2012},
}
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