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P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells

Joana Paredes, Christophe Stove UGent, Veronique Stove UGent, Fernanda Milanezi, Veerle Van Marck UGent, Lara Derycke UGent, Marcus Mareel, Marc Bracke UGent and Fernando Schmitt (2004) CANCER RESEARCH. 64(22). p.8309-8317
abstract
P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
P120 CATENIN, GROWTH-FACTOR RECEPTOR, EXPRESSION, ADHESION, COLON-CARCINOMA CELLS, N-CADHERIN, ESTROGEN-RECEPTOR, EPITHELIAL TISSUES, PURE-ANTIESTROGEN, PROSTATE-CANCER
journal title
CANCER RESEARCH
Cancer Res.
volume
64
issue
22
pages
8309 - 8317
Web of Science type
Article
Web of Science id
000225182300026
JCR category
ONCOLOGY
JCR impact factor
7.69 (2004)
JCR rank
8/120 (2004)
JCR quartile
1 (2004)
ISSN
0008-5472
DOI
10.1158/0008-5472.CAN-04-0795
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally to this article and should be considered as first authors
copyright statement
I have transferred the copyright for this publication to the publisher
id
297431
handle
http://hdl.handle.net/1854/LU-297431
date created
2005-01-13 16:17:00
date last changed
2016-12-19 15:42:29
@article{297431,
  abstract     = {P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.},
  author       = {Paredes, Joana and Stove, Christophe and Stove, Veronique and Milanezi, Fernanda and Van Marck, Veerle and Derycke, Lara and Mareel, Marcus and Bracke, Marc and Schmitt, Fernando},
  issn         = {0008-5472},
  journal      = {CANCER RESEARCH},
  keyword      = {P120 CATENIN,GROWTH-FACTOR RECEPTOR,EXPRESSION,ADHESION,COLON-CARCINOMA CELLS,N-CADHERIN,ESTROGEN-RECEPTOR,EPITHELIAL TISSUES,PURE-ANTIESTROGEN,PROSTATE-CANCER},
  language     = {eng},
  number       = {22},
  pages        = {8309--8317},
  title        = {P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-04-0795},
  volume       = {64},
  year         = {2004},
}

Chicago
Paredes, Joana, Christophe Stove, Veronique Stove, Fernanda Milanezi, Veerle Van Marck, Lara Derycke, MARCUS MAREEL, Marc Bracke, and Fernando Schmitt. 2004. “P-cadherin Is Up-regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells.” Cancer Research 64 (22): 8309–8317.
APA
Paredes, J., Stove, C., Stove, V., Milanezi, F., Van Marck, V., Derycke, L., MAREEL, M., et al. (2004). P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. CANCER RESEARCH, 64(22), 8309–8317.
Vancouver
1.
Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, et al. P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. CANCER RESEARCH. 2004;64(22):8309–17.
MLA
Paredes, Joana, Christophe Stove, Veronique Stove, et al. “P-cadherin Is Up-regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells.” CANCER RESEARCH 64.22 (2004): 8309–8317. Print.