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P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells

(2004) CANCER RESEARCH. 64(22). p.8309-8317
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Abstract
P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.
Keywords
P120 CATENIN, GROWTH-FACTOR RECEPTOR, EXPRESSION, ADHESION, COLON-CARCINOMA CELLS, N-CADHERIN, ESTROGEN-RECEPTOR, EPITHELIAL TISSUES, PURE-ANTIESTROGEN, PROSTATE-CANCER

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Chicago
Paredes, Joana, Christophe Stove, Veronique Stove, Fernanda Milanezi, Veerle Van Marck, Lara Derycke, Marcus Mareel, Marc Bracke, and Fernando Schmitt. 2004. “P-cadherin Is Up-regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells.” Cancer Research 64 (22): 8309–8317.
APA
Paredes, J., Stove, C., Stove, V., Milanezi, F., Van Marck, V., Derycke, L., Mareel, M., et al. (2004). P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. CANCER RESEARCH, 64(22), 8309–8317.
Vancouver
1.
Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, et al. P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. CANCER RESEARCH. 2004;64(22):8309–17.
MLA
Paredes, Joana, Christophe Stove, Veronique Stove, et al. “P-cadherin Is Up-regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells.” CANCER RESEARCH 64.22 (2004): 8309–8317. Print.
@article{297431,
  abstract     = {P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.},
  author       = {Paredes, Joana and Stove, Christophe and Stove, Veronique and Milanezi, Fernanda and Van Marck, Veerle and Derycke, Lara and Mareel, Marcus and Bracke, Marc and Schmitt, Fernando},
  issn         = {0008-5472},
  journal      = {CANCER RESEARCH},
  keyword      = {P120 CATENIN,GROWTH-FACTOR RECEPTOR,EXPRESSION,ADHESION,COLON-CARCINOMA CELLS,N-CADHERIN,ESTROGEN-RECEPTOR,EPITHELIAL TISSUES,PURE-ANTIESTROGEN,PROSTATE-CANCER},
  language     = {eng},
  number       = {22},
  pages        = {8309--8317},
  title        = {P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells},
  url          = {http://dx.doi.org/10.1158/0008-5472.CAN-04-0795},
  volume       = {64},
  year         = {2004},
}

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