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Muscle-tendon tissue properties in the hypermobility type of Ehlers-Danlos Syndrome

Lies Rombaut UGent, Fransiska Malfait UGent, Inge De Wandele UGent, Nele Mahieu UGent, Youri Thijs UGent, Patrick Segers UGent, Anne De Paepe UGent and Patrick Calders UGent (2012) ARTHRITIS CARE AND RESEARCH. 64(5). p.766-772
abstract
Objective. To investigate the passive properties of the plantar flexors muscle-tendon tissue in patients with the hypermobility type of Ehlers-Danlos syndrome (EDS-HT). Methods. Twenty-five women with EDS-HT and 25 sex-and age-matched healthy control subjects participated in the study. Passive resistive torque (PRT) of the plantar flexors was measured with an isokinetic dynamometer during 2 standardized stretch protocols to obtain the passive muscle tension. Protocol 1 consisted of 4 continuous cycles to a predetermined angle of 10 degrees dorsiflexion. Protocol 2 consisted of a slow stretch to the onset of pain. Torque, angle, and electromyography were simultaneously recorded during the tests. To take muscle thickness into account, muscle cross-sectional area (MCSA) was obtained with peripheral quantitative computed tomography. Stiffness of the Achilles tendon was assessed using a dynamometer in combination with ultrasonography. Results. The results demonstrate a significantly larger maximal joint angle in the EDS-HT patients accompanied by a similar PRT compared to the control subjects (protocol 2), indicating a lower passive muscle tension in the patient group. PRT for the predetermined angle (protocol 1) was the same for both groups and there was no difference in MSCA. Furthermore, a significantly lower Achilles tendon stiffness was seen in the patient group than in the control group. Conclusion. This study is the first to provide evidence for altered passive properties of the muscle-tendon unit in EDS-HT patients. These changes are thought to be associated with structural modifications in connective tissue.
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author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
VISCOELASTIC PROPERTIES, CROSS-SECTIONAL AREA, CONNECTIVE-TISSUE, IN-VIVO, JOINT HYPERMOBILITY, HERITABLE DISORDERS, STABILIZING SYSTEM, PASSIVE STIFFNESS, SKELETAL-MUSCLE, FLEXIBILITY
journal title
ARTHRITIS CARE AND RESEARCH
Arthritis Care Res.
volume
64
issue
5
pages
766 - 772
Web of Science type
Article
Web of Science id
000305790500016
ISSN
0893-7524
DOI
10.1002/acr.21592
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2973035
handle
http://hdl.handle.net/1854/LU-2973035
date created
2012-08-20 15:17:44
date last changed
2013-07-08 15:54:22
@article{2973035,
  abstract     = {Objective. To investigate the passive properties of the plantar flexors muscle-tendon tissue in patients with the hypermobility type of Ehlers-Danlos syndrome (EDS-HT). 
Methods. Twenty-five women with EDS-HT and 25 sex-and age-matched healthy control subjects participated in the study. Passive resistive torque (PRT) of the plantar flexors was measured with an isokinetic dynamometer during 2 standardized stretch protocols to obtain the passive muscle tension. Protocol 1 consisted of 4 continuous cycles to a predetermined angle of 10 degrees dorsiflexion. Protocol 2 consisted of a slow stretch to the onset of pain. Torque, angle, and electromyography were simultaneously recorded during the tests. To take muscle thickness into account, muscle cross-sectional area (MCSA) was obtained with peripheral quantitative computed tomography. Stiffness of the Achilles tendon was assessed using a dynamometer in combination with ultrasonography. 
Results. The results demonstrate a significantly larger maximal joint angle in the EDS-HT patients accompanied by a similar PRT compared to the control subjects (protocol 2), indicating a lower passive muscle tension in the patient group. PRT for the predetermined angle (protocol 1) was the same for both groups and there was no difference in MSCA. Furthermore, a significantly lower Achilles tendon stiffness was seen in the patient group than in the control group. 
Conclusion. This study is the first to provide evidence for altered passive properties of the muscle-tendon unit in EDS-HT patients. These changes are thought to be associated with structural modifications in connective tissue.},
  author       = {Rombaut, Lies and Malfait, Fransiska and De Wandele, Inge and Mahieu, Nele and Thijs, Youri and Segers, Patrick and De Paepe, Anne and Calders, Patrick},
  issn         = {0893-7524},
  journal      = {ARTHRITIS CARE AND RESEARCH},
  keyword      = {VISCOELASTIC PROPERTIES,CROSS-SECTIONAL AREA,CONNECTIVE-TISSUE,IN-VIVO,JOINT HYPERMOBILITY,HERITABLE DISORDERS,STABILIZING SYSTEM,PASSIVE STIFFNESS,SKELETAL-MUSCLE,FLEXIBILITY},
  language     = {eng},
  number       = {5},
  pages        = {766--772},
  title        = {Muscle-tendon tissue properties in the hypermobility type of Ehlers-Danlos Syndrome},
  url          = {http://dx.doi.org/10.1002/acr.21592},
  volume       = {64},
  year         = {2012},
}

Chicago
Rombaut, Lies, Fransiska Malfait, Inge De Wandele, Nele Mahieu, Youri Thijs, Patrick Segers, Anne De Paepe, and Patrick Calders. 2012. “Muscle-tendon Tissue Properties in the Hypermobility Type of Ehlers-Danlos Syndrome.” Arthritis Care and Research 64 (5): 766–772.
APA
Rombaut, L., Malfait, F., De Wandele, I., Mahieu, N., Thijs, Y., Segers, P., De Paepe, A., et al. (2012). Muscle-tendon tissue properties in the hypermobility type of Ehlers-Danlos Syndrome. ARTHRITIS CARE AND RESEARCH, 64(5), 766–772.
Vancouver
1.
Rombaut L, Malfait F, De Wandele I, Mahieu N, Thijs Y, Segers P, et al. Muscle-tendon tissue properties in the hypermobility type of Ehlers-Danlos Syndrome. ARTHRITIS CARE AND RESEARCH. 2012;64(5):766–72.
MLA
Rombaut, Lies, Fransiska Malfait, Inge De Wandele, et al. “Muscle-tendon Tissue Properties in the Hypermobility Type of Ehlers-Danlos Syndrome.” ARTHRITIS CARE AND RESEARCH 64.5 (2012): 766–772. Print.