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Occupational exposure to sevoflurane during cardiopulmonary bypass

MJ Blokker-Veldhuis, PMMJ Rutten and Stefan De Hert UGent (2011) PERFUSION-UK. 26(5). p.383-389
abstract
Volatile anaesthetic agents are widely used for maintenance of anaesthesia in all kinds of surgical procedures. Despite the implementation of measures such as adequate ventilation of the operating room and the use of efficient scavenging systems, concern remains about the risks for occupational exposure, especially in situations associated with an increased risk of anaesthetic gas waste, such as with the use of volatile anaesthetic agents on cardiopulmonary bypass. The present contribution reports the results of a preliminary safety assessment involving measurements of sevoflurane concentrations in the ambient air of a cardiac surgery operating room. In 22 cardiac surgical procedures with cardiopulmonary bypass (11 with open and 11 with closed venous reservoir), measurements of trace concentrations were obtained every 10 min at the following sites: at the outlet of the oxygenator, at the outlet of the cardiotomy reservoir, in the breathing zone of the perfusionist and above the surgical field. The concentrations were measured on-line using a photoacoustic infrared spectrometer. Mean sevoflurane waste concentrations remained consistently below the recommended target value of 4.68 ppm throughout the observation period at the different measurement sites. These results indicate that, with the use of sevoflurane on cardiopulmonary bypass, the recommended levels for occupational exposure are not exceeded, provided adequate operation room ventilation and waste gas scavenging is performed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
occupational hazard, waste anaesthetic gases, cardiac surgery, sevoflurane, cardiopulmonary bypass, OPERATING-ROOM PERSONNEL, VOLATILE ANESTHETICS, CORONARY SURGERY, SUBANESTHETIC CONCENTRATIONS, NITROUS-OXIDE, INHALED ANESTHETICS, MYOCARDIAL-FUNCTION, HEALTHY-VOLUNTEERS, DENTAL ASSISTANTS, CARDIAC-SURGERY
journal title
PERFUSION-UK
Perfusion-UK
volume
26
issue
5
pages
383 - 389
Web of Science type
Article
Web of Science id
000294633600006
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
0.918 (2011)
JCR rank
95/117 (2011)
JCR quartile
4 (2011)
ISSN
0267-6591
DOI
10.1177/0267659111409971
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2971661
handle
http://hdl.handle.net/1854/LU-2971661
date created
2012-08-14 11:18:10
date last changed
2016-12-19 15:42:26
@article{2971661,
  abstract     = {Volatile anaesthetic agents are widely used for maintenance of anaesthesia in all kinds of surgical procedures. Despite the implementation of measures such as adequate ventilation of the operating room and the use of efficient scavenging systems, concern remains about the risks for occupational exposure, especially in situations associated with an increased risk of anaesthetic gas waste, such as with the use of volatile anaesthetic agents on cardiopulmonary bypass. The present contribution reports the results of a preliminary safety assessment involving measurements of sevoflurane concentrations in the ambient air of a cardiac surgery operating room. 
In 22 cardiac surgical procedures with cardiopulmonary bypass (11 with open and 11 with closed venous reservoir), measurements of trace concentrations were obtained every 10 min at the following sites: at the outlet of the oxygenator, at the outlet of the cardiotomy reservoir, in the breathing zone of the perfusionist and above the surgical field. The concentrations were measured on-line using a photoacoustic infrared spectrometer. 
Mean sevoflurane waste concentrations remained consistently below the recommended target value of 4.68 ppm throughout the observation period at the different measurement sites. 
These results indicate that, with the use of sevoflurane on cardiopulmonary bypass, the recommended levels for occupational exposure are not exceeded, provided adequate operation room ventilation and waste gas scavenging is performed.},
  author       = {Blokker-Veldhuis, MJ and Rutten, PMMJ and De Hert, Stefan},
  issn         = {0267-6591},
  journal      = {PERFUSION-UK},
  keyword      = {occupational hazard,waste anaesthetic gases,cardiac surgery,sevoflurane,cardiopulmonary bypass,OPERATING-ROOM PERSONNEL,VOLATILE ANESTHETICS,CORONARY SURGERY,SUBANESTHETIC CONCENTRATIONS,NITROUS-OXIDE,INHALED ANESTHETICS,MYOCARDIAL-FUNCTION,HEALTHY-VOLUNTEERS,DENTAL ASSISTANTS,CARDIAC-SURGERY},
  language     = {eng},
  number       = {5},
  pages        = {383--389},
  title        = {Occupational exposure to sevoflurane during cardiopulmonary bypass},
  url          = {http://dx.doi.org/10.1177/0267659111409971},
  volume       = {26},
  year         = {2011},
}

Chicago
Blokker-Veldhuis, MJ, PMMJ Rutten, and Stefan De Hert. 2011. “Occupational Exposure to Sevoflurane During Cardiopulmonary Bypass.” Perfusion-uk 26 (5): 383–389.
APA
Blokker-Veldhuis, M., Rutten, P., & De Hert, S. (2011). Occupational exposure to sevoflurane during cardiopulmonary bypass. PERFUSION-UK, 26(5), 383–389.
Vancouver
1.
Blokker-Veldhuis M, Rutten P, De Hert S. Occupational exposure to sevoflurane during cardiopulmonary bypass. PERFUSION-UK. 2011;26(5):383–9.
MLA
Blokker-Veldhuis, MJ, PMMJ Rutten, and Stefan De Hert. “Occupational Exposure to Sevoflurane During Cardiopulmonary Bypass.” PERFUSION-UK 26.5 (2011): 383–389. Print.