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Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration

Dilek Coban, Dragan Milenkovic, Audrey Chanet, Jamila Khallou-Laschet, Linde Sabbe UGent, Ajay Palagani UGent, Wim Vanden Berghe UGent, Andrzej Mazur and Christine Morand (2012) MOLECULAR NUTRITION & FOOD RESEARCH. 56(8). p.1270-1281
abstract
Scope : The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level. Methods and results : ApoE/ mice were fed with curcumin at 0.2% (wt/wt) in diet for 4 months. This supplementation reduced the extent of atherosclerotic lesion by 26% and induced changes in expression of genes implicated in cell adhesion and transendothelial migration or cytoskeleton organization, as revealed by a transcriptomic analysis in the aorta. Expression profile of these genes suggests reduction in both leukocyte adhesion and transendothelial migration. In agreement with this hypothesis, we observed a reduction (37%) in macrophage infiltration in the plaque, as measured by immunohistochemistry, and, in vitro, a lower adhesion of monocytes to TNF-a-stimulated endothelial cells (32%) after exposure to a nutritionally achievable concentration of curcumin. These changes in gene expression could be related to the observed increased expression of I?B protein and decrease of TNF-a-induced NF-?B/DNA binding and NF-?B-transcriptional activity upon exposure to curcumin. Conclusion : Our findings pointed out that the antiatherogenic effect of curcumin could be linked to its effect on gene networks and cell functions related to leukocyte adhesion and transendothelial migration via NF-?B-dependent pathways.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Curcumin, Atherosclerosis, Macrophage infiltration, Monocyte adhesion, Nutrigenomics, FACTOR-KAPPA-B, INFLAMMATORY BOWEL DISEASES, I CLINICAL-TRIAL, NUCLEAR-FACTOR, ENDOTHELIAL-CELLS, KNOCKOUT MICE, ACTIVATION, CANCER, PATHWAY, RATS
journal title
MOLECULAR NUTRITION & FOOD RESEARCH
Mol. Nutr. Food Res.
volume
56
issue
8
pages
1270 - 1281
Web of Science type
Article
Web of Science id
000307542500010
JCR category
FOOD SCIENCE & TECHNOLOGY
JCR impact factor
4.31 (2012)
JCR rank
4/123 (2012)
JCR quartile
1 (2012)
ISSN
1613-4125
DOI
10.1002/mnfr.201100818
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2971359
handle
http://hdl.handle.net/1854/LU-2971359
date created
2012-08-13 14:31:10
date last changed
2012-10-19 16:51:02
@article{2971359,
  abstract     = {Scope : The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level.
Methods and results : ApoE/ mice were fed with curcumin at 0.2\% (wt/wt) in diet for 4 months. This supplementation reduced the extent of atherosclerotic lesion by 26\% and induced changes in expression of genes implicated in cell adhesion and transendothelial migration or cytoskeleton organization, as revealed by a transcriptomic analysis in the aorta. Expression profile of these genes suggests reduction in both leukocyte adhesion and transendothelial migration. In agreement with this hypothesis, we observed a reduction (37\%) in macrophage infiltration in the plaque, as measured by immunohistochemistry, and, in vitro, a lower adhesion of monocytes to TNF-a-stimulated endothelial cells (32\%) after exposure to a nutritionally achievable concentration of curcumin. These changes in gene expression could be related to the observed increased expression of I?B protein and decrease of TNF-a-induced NF-?B/DNA binding and NF-?B-transcriptional activity upon exposure to curcumin.
Conclusion : Our findings pointed out that the antiatherogenic effect of curcumin could be linked to its effect on gene networks and cell functions related to leukocyte adhesion and transendothelial migration via NF-?B-dependent pathways.},
  author       = {Coban, Dilek and Milenkovic, Dragan and Chanet, Audrey and Khallou-Laschet, Jamila and Sabbe, Linde and Palagani, Ajay and Vanden Berghe, Wim and Mazur, Andrzej and Morand, Christine},
  issn         = {1613-4125},
  journal      = {MOLECULAR NUTRITION \& FOOD RESEARCH},
  keyword      = {Curcumin,Atherosclerosis,Macrophage infiltration,Monocyte adhesion,Nutrigenomics,FACTOR-KAPPA-B,INFLAMMATORY BOWEL DISEASES,I CLINICAL-TRIAL,NUCLEAR-FACTOR,ENDOTHELIAL-CELLS,KNOCKOUT MICE,ACTIVATION,CANCER,PATHWAY,RATS},
  language     = {eng},
  number       = {8},
  pages        = {1270--1281},
  title        = {Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration},
  url          = {http://dx.doi.org/10.1002/mnfr.201100818},
  volume       = {56},
  year         = {2012},
}

Chicago
Coban, Dilek, Dragan Milenkovic, Audrey Chanet, Jamila Khallou-Laschet, Linde Sabbe, Ajay Palagani, Wim Vanden Berghe, Andrzej Mazur, and Christine Morand. 2012. “Dietary Curcumin Inhibits Atherosclerosis by Affecting the Expression of Genes Involved in Leukocyte Adhesion and Transendothelial Migration.” Molecular Nutrition & Food Research 56 (8): 1270–1281.
APA
Coban, D., Milenkovic, D., Chanet, A., Khallou-Laschet, J., Sabbe, L., Palagani, A., Vanden Berghe, W., et al. (2012). Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. MOLECULAR NUTRITION & FOOD RESEARCH, 56(8), 1270–1281.
Vancouver
1.
Coban D, Milenkovic D, Chanet A, Khallou-Laschet J, Sabbe L, Palagani A, et al. Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. MOLECULAR NUTRITION & FOOD RESEARCH. 2012;56(8):1270–81.
MLA
Coban, Dilek, Dragan Milenkovic, Audrey Chanet, et al. “Dietary Curcumin Inhibits Atherosclerosis by Affecting the Expression of Genes Involved in Leukocyte Adhesion and Transendothelial Migration.” MOLECULAR NUTRITION & FOOD RESEARCH 56.8 (2012): 1270–1281. Print.