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Clinical significance of Koebner's phenomenon in vitiligo

Nanja van Geel UGent, Reinhart Speeckaert UGent, J De Wolf, Stefanie Bracke UGent, Ines Chevolet UGent, Lieve Brochez UGent and Jo Lambert UGent (2012) BRITISH JOURNAL OF DERMATOLOGY. 167(5). p.1017-1024
abstract
Background:  The clinical significance of Koebner's phenomenon (KP) in vitiligo with respect to disease activity and course is still debatable. Recently, a new classification is introduced for the assessment of KP. Objectives:  To evaluate the new assessment method for KP in clinical practice and to determine its clinical significance, both with respect to the clinical profile, course of vitiligo and treatment response. Methods:  Seven hundred generalized vitiligo patients were included in this observational cohort study. KP was classified according to the new classification system in different subtypes [KP1: by history, KP2A and KP2B: by clinical examination (A: lesions on friction areas, B: linear, artefactual lesions)]. Results:  KP1 was positive in 34.1% of the patients, 66.3% were KP2A positive and 15.1% had KP2B. The BSA was significantly (P<0.001) higher in presence of any KP subtype and more disease activity was found in KP1+ and KP2B+ patients. An earlier age of onset and elevated risk of further depigmentation despite treatment was observed in all KP positive groups. In KP2A+ and KP2B+ patients, depigmentation of wrists/ankles was more common. In the KP2A+ group, a significant higher prevalence of thyroid disease was found while autoimmune diseases were less prevalent in KP2B+ patients. Conclusion:  The new assessment method for KP, taking into account both history and clinical examination, seems to be a useful and valuable tool to asses KP in daily practice. Our results support the hypothesis that KP may function as a clinical parameter to assess and predict the clinical profile and course of vitiligo.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
BRITISH JOURNAL OF DERMATOLOGY
Br. J. Dermatol.
volume
167
issue
5
pages
1017 - 1024
Web of Science type
Article
Web of Science id
000310542200009
JCR category
DERMATOLOGY
JCR impact factor
3.759 (2012)
JCR rank
5/58 (2012)
JCR quartile
1 (2012)
ISSN
0007-0963
DOI
10.1111/j.1365-2133.2012.11111.x.
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2968547
handle
http://hdl.handle.net/1854/LU-2968547
date created
2012-08-06 17:13:08
date last changed
2013-07-09 15:06:15
@article{2968547,
  abstract     = {Background:\phantom{N} The clinical significance of Koebner's phenomenon (KP) in vitiligo with respect to disease activity and course is still debatable. Recently, a new classification is introduced for the assessment of KP. Objectives:\phantom{N} To evaluate the new assessment method for KP in clinical practice and to determine its clinical significance, both with respect to the clinical profile, course of vitiligo and treatment response. Methods:\phantom{N} Seven hundred generalized vitiligo patients were included in this observational cohort study. KP was classified according to the new classification system in different subtypes [KP1: by history, KP2A and KP2B: by clinical examination (A: lesions on friction areas, B: linear, artefactual lesions)]. Results:\phantom{N} KP1 was positive in 34.1\% of the patients, 66.3\% were KP2A positive and 15.1\% had KP2B. The BSA was significantly (P{\textlangle}0.001) higher in presence of any KP subtype and more disease activity was found in KP1+ and KP2B+ patients. An earlier age of onset and elevated risk of further depigmentation despite treatment was observed in all KP positive groups. In KP2A+ and KP2B+ patients, depigmentation of wrists/ankles was more common. In the KP2A+ group, a significant higher prevalence of thyroid disease was found while autoimmune diseases were less prevalent in KP2B+ patients. Conclusion:\phantom{N} The new assessment method for KP, taking into account both history and clinical examination, seems to be a useful and valuable tool to asses KP in daily practice. Our results support the hypothesis that KP may function as a clinical parameter to assess and predict the clinical profile and course of vitiligo.},
  author       = {van Geel, Nanja and Speeckaert, Reinhart and De Wolf, J and Bracke, Stefanie and Chevolet, Ines and Brochez, Lieve and Lambert, Jo},
  issn         = {0007-0963},
  journal      = {BRITISH JOURNAL OF DERMATOLOGY},
  language     = {eng},
  number       = {5},
  pages        = {1017--1024},
  title        = {Clinical significance of Koebner's phenomenon in vitiligo},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2012.11111.x.},
  volume       = {167},
  year         = {2012},
}

Chicago
van Geel, Nanja, Reinhart Speeckaert, J De Wolf, Stefanie Bracke, Ines Chevolet, Lieve Brochez, and Jo Lambert. 2012. “Clinical Significance of Koebner’s Phenomenon in Vitiligo.” British Journal of Dermatology 167 (5): 1017–1024.
APA
van Geel, N., Speeckaert, R., De Wolf, J., Bracke, S., Chevolet, I., Brochez, L., & Lambert, J. (2012). Clinical significance of Koebner’s phenomenon in vitiligo. BRITISH JOURNAL OF DERMATOLOGY, 167(5), 1017–1024.
Vancouver
1.
van Geel N, Speeckaert R, De Wolf J, Bracke S, Chevolet I, Brochez L, et al. Clinical significance of Koebner’s phenomenon in vitiligo. BRITISH JOURNAL OF DERMATOLOGY. 2012;167(5):1017–24.
MLA
van Geel, Nanja, Reinhart Speeckaert, J De Wolf, et al. “Clinical Significance of Koebner’s Phenomenon in Vitiligo.” BRITISH JOURNAL OF DERMATOLOGY 167.5 (2012): 1017–1024. Print.