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Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

Alexander Gheldof UGent, Paco Hulpiau UGent, Frans Van Roy UGent, Bram De Craene UGent and Geert Berx UGent (2012) CELLULAR AND MOLECULAR LIFE SCIENCES. 69(15). p.2527-2541
abstract
ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive the process of epithelial-mesenchymal transition during malignant cancer progression. The understanding of how both ZEBs act as transcription factors opens up new possibilities for future treatment of advanced carcinomas. This review gives insight into the molecular mechanisms that form the basis of the multitude of cellular processes controlled by both ZEB factors. By using an evolutionary approach, we analyzed how the specific organization of the different domains and regulatory sites in ZEB1 and ZEB2 came into existence. On the basis of this analysis, a detailed overview is provided of the different cofactors and post-translational mechanisms that are associated with ZEB protein functionality.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Evolution, Neural crest cells, ZEB transcription factors, EMT, CtBP, TGF-beta, EPITHELIAL-MESENCHYMAL TRANSITION, SMAD-INTERACTING PROTEIN-1, ZINC-FINGER PROTEIN, TGF-BETA, E-CADHERIN, BINDING-PROTEIN, GENE-EXPRESSION, COREPRESSOR CTBP, DOWN-REGULATION, MIR-200 FAMILY
journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
Cell. Mol. Life Sci.
volume
69
issue
15
pages
2527 - 2541
Web of Science type
Review
Web of Science id
000306335000006
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
5.615 (2012)
JCR rank
45/288 (2012)
JCR quartile
1 (2012)
ISSN
1420-682X
DOI
10.1007/s00018-012-0935-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2968108
handle
http://hdl.handle.net/1854/LU-2968108
date created
2012-08-06 12:41:49
date last changed
2012-08-07 14:34:33
@article{2968108,
  abstract     = {ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal role in the development of the vertebrate embryo. However, recent evidence shows that both proteins can also drive the process of epithelial-mesenchymal transition during malignant cancer progression. The understanding of how both ZEBs act as transcription factors opens up new possibilities for future treatment of advanced carcinomas. This review gives insight into the molecular mechanisms that form the basis of the multitude of cellular processes controlled by both ZEB factors. By using an evolutionary approach, we analyzed how the specific organization of the different domains and regulatory sites in ZEB1 and ZEB2 came into existence. On the basis of this analysis, a detailed overview is provided of the different cofactors and post-translational mechanisms that are associated with ZEB protein functionality.},
  author       = {Gheldof, Alexander and Hulpiau, Paco and Van Roy, Frans and De Craene, Bram and Berx, Geert},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keyword      = {Evolution,Neural crest cells,ZEB transcription factors,EMT,CtBP,TGF-beta,EPITHELIAL-MESENCHYMAL TRANSITION,SMAD-INTERACTING PROTEIN-1,ZINC-FINGER PROTEIN,TGF-BETA,E-CADHERIN,BINDING-PROTEIN,GENE-EXPRESSION,COREPRESSOR CTBP,DOWN-REGULATION,MIR-200 FAMILY},
  language     = {eng},
  number       = {15},
  pages        = {2527--2541},
  title        = {Evolutionary functional analysis and molecular regulation of the ZEB transcription factors},
  url          = {http://dx.doi.org/10.1007/s00018-012-0935-3},
  volume       = {69},
  year         = {2012},
}

Chicago
Gheldof, Alexander, Paco Hulpiau, Frans Van Roy, Bram De Craene, and Geert Berx. 2012. “Evolutionary Functional Analysis and Molecular Regulation of the ZEB Transcription Factors.” Cellular and Molecular Life Sciences 69 (15): 2527–2541.
APA
Gheldof, A., Hulpiau, P., Van Roy, F., De Craene, B., & Berx, G. (2012). Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. CELLULAR AND MOLECULAR LIFE SCIENCES, 69(15), 2527–2541.
Vancouver
1.
Gheldof A, Hulpiau P, Van Roy F, De Craene B, Berx G. Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. CELLULAR AND MOLECULAR LIFE SCIENCES. 2012;69(15):2527–41.
MLA
Gheldof, Alexander, Paco Hulpiau, Frans Van Roy, et al. “Evolutionary Functional Analysis and Molecular Regulation of the ZEB Transcription Factors.” CELLULAR AND MOLECULAR LIFE SCIENCES 69.15 (2012): 2527–2541. Print.