Ghent University Academic Bibliography

Advanced

Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease

Stephanie Coulon UGent, Sven Francque, Isabelle Colle UGent, An Verrijken, BRAM BLOMME UGent, Femke Heindryckx UGent, Steffi De Munter UGent, Janne Prawitt, Sandrine Caron and Bart Staels, et al. (2012) CYTOKINE. 59(2). p.442-449
abstract
The liver is a major target of injury in obese patients. Non-alcoholic fatty liver disease (NAFLD) is present in 60-90% of obese Americans and can range from simple steatosis to the more severe non-alcoholic steatohepatitis (NASH). The onset of a chronic inflammatory reaction marks the progression from simple steatosis to NASH and the expansion of adipose tissue is strongly associated with angiogenesis. Therefore, we determined the serum concentration of inflammatory [tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6)] and angiogenic [vascular endothelial growth factor A (VEGF)] cytokines and soluble VEGF receptors 1 and 2 (sVEGFR1, sVEGFR2) in the serum of an obese population with simple steatosis and NASH compared to healthy controls. Moreover, we determined the TNF alpha, IL6, VEGF, VEGFR1 and VEGFR2 gene expression in the liver of these simple steatosis and NASH patients. The population consisted of 30 obese patients, which were diagnosed with simple steatosis and 32 patients with NASH and compared to 30 age-and-sex matched healthy controls. Mean serum TNF alpha levels were elevated in the serum of simple steatosis and NASH patients compared to healthy controls, reaching significance in NASH patients. IL6 was significantly increased in simple steatosis and NASH patients compared to the healthy controls. VEGF levels were significantly elevated in patients with simple steatosis and borderline significantly elevated in NASH patients compared to the serum levels of healthy control subjects. The concentration of sVEGFR1 was significantly increased in serum of simple steatosis and NASH patients compared to controls. sVEGFR2 concentration was not significantly different in the three groups. TNF alpha mRNA expression was higher in NASH patients compared to simple steatosis patients. Hepatic gene expression of VEGF, VEGFR1 and VEGFR2 were slightly decreased in NASH patients compared to simple steatosis patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TUMOR-NECROSIS-FACTOR, ENDOTHELIAL GROWTH-FACTOR, Tumor necrosis factor alpha, Interleukin 6, Vascular endothelial growth factor receptor, Vascular endothelial growth factor, Non-alcoholic fatty liver disease, FACTOR-ALPHA, HEPATOCELLULAR-CARCINOMA, INSULIN-RESISTANCE, OBESE-PATIENTS, FACTOR RECEPTOR-1, GENE-EXPRESSION, TNF-ALPHA, IN-VIVO
journal title
CYTOKINE
Cytokine
volume
59
issue
2
pages
442 - 449
Web of Science type
Article
Web of Science id
000306159200038
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
2.518 (2012)
JCR rank
171/288 (2012)
JCR quartile
3 (2012)
ISSN
1043-4666
DOI
10.1016/j.cyto.2012.05.001
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2967404
handle
http://hdl.handle.net/1854/LU-2967404
date created
2012-08-03 13:20:54
date last changed
2012-08-09 11:58:11
@article{2967404,
  abstract     = {The liver is a major target of injury in obese patients. Non-alcoholic fatty liver disease (NAFLD) is present in 60-90\% of obese Americans and can range from simple steatosis to the more severe non-alcoholic steatohepatitis (NASH). The onset of a chronic inflammatory reaction marks the progression from simple steatosis to NASH and the expansion of adipose tissue is strongly associated with angiogenesis. Therefore, we determined the serum concentration of inflammatory [tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6)] and angiogenic [vascular endothelial growth factor A (VEGF)] cytokines and soluble VEGF receptors 1 and 2 (sVEGFR1, sVEGFR2) in the serum of an obese population with simple steatosis and NASH compared to healthy controls. Moreover, we determined the TNF alpha, IL6, VEGF, VEGFR1 and VEGFR2 gene expression in the liver of these simple steatosis and NASH patients. The population consisted of 30 obese patients, which were diagnosed with simple steatosis and 32 patients with NASH and compared to 30 age-and-sex matched healthy controls. Mean serum TNF alpha levels were elevated in the serum of simple steatosis and NASH patients compared to healthy controls, reaching significance in NASH patients. IL6 was significantly increased in simple steatosis and NASH patients compared to the healthy controls. VEGF levels were significantly elevated in patients with simple steatosis and borderline significantly elevated in NASH patients compared to the serum levels of healthy control subjects. The concentration of sVEGFR1 was significantly increased in serum of simple steatosis and NASH patients compared to controls. sVEGFR2 concentration was not significantly different in the three groups. TNF alpha mRNA expression was higher in NASH patients compared to simple steatosis patients. Hepatic gene expression of VEGF, VEGFR1 and VEGFR2 were slightly decreased in NASH patients compared to simple steatosis patients.},
  author       = {Coulon, Stephanie and Francque, Sven and Colle, Isabelle and Verrijken, An and BLOMME, BRAM and Heindryckx, Femke and De Munter, Steffi and Prawitt, Janne and Caron, Sandrine and Staels, Bart and Van Vlierberghe, Hans and Van Gaal, Luc and Geerts, Anja},
  issn         = {1043-4666},
  journal      = {CYTOKINE},
  keyword      = {TUMOR-NECROSIS-FACTOR,ENDOTHELIAL GROWTH-FACTOR,Tumor necrosis factor alpha,Interleukin 6,Vascular endothelial growth factor receptor,Vascular endothelial growth factor,Non-alcoholic fatty liver disease,FACTOR-ALPHA,HEPATOCELLULAR-CARCINOMA,INSULIN-RESISTANCE,OBESE-PATIENTS,FACTOR RECEPTOR-1,GENE-EXPRESSION,TNF-ALPHA,IN-VIVO},
  language     = {eng},
  number       = {2},
  pages        = {442--449},
  title        = {Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease},
  url          = {http://dx.doi.org/10.1016/j.cyto.2012.05.001},
  volume       = {59},
  year         = {2012},
}

Chicago
Coulon, Stephanie, Sven Francque, Isabelle Colle, An Verrijken, BRAM BLOMME, Femke Heindryckx, Steffi De Munter, et al. 2012. “Evaluation of Inflammatory and Angiogenic Factors in Patients with Non-alcoholic Fatty Liver Disease.” Cytokine 59 (2): 442–449.
APA
Coulon, S., Francque, S., Colle, I., Verrijken, A., BLOMME, B., Heindryckx, F., De Munter, S., et al. (2012). Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease. CYTOKINE, 59(2), 442–449.
Vancouver
1.
Coulon S, Francque S, Colle I, Verrijken A, BLOMME B, Heindryckx F, et al. Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease. CYTOKINE. 2012;59(2):442–9.
MLA
Coulon, Stephanie, Sven Francque, Isabelle Colle, et al. “Evaluation of Inflammatory and Angiogenic Factors in Patients with Non-alcoholic Fatty Liver Disease.” CYTOKINE 59.2 (2012): 442–449. Print.