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Efficacy and safety testing of mycotocoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines

Ann Osselaere UGent, Mathias Devreese UGent, Anneleen Watteyn UGent, Virginie Vandenbroucke UGent, Joline Goossens UGent, Veerle Hautekiet, Mia Eeckhout UGent, Sarah De Saeger UGent, Siegrid De Baere UGent and Patrick De Backer UGent, et al. (2012) POULTRY SCIENCE. 91(8). p.2046-2054
abstract
Contamination of feeds with mycotoxins is a worldwide problem and mycotoxin-detoxifying agents are used to decrease their negative effect. The European Food Safety Authority recently stated guidelines and end-points for the efficacy testing of detoxifiers. Our study revealed that plasma concentrations of deoxynivalenol and deepoxy-deoxynivalenol were too low to assess efficacy of 2 commercially available mycotoxin-detoxifying agents against deoxynivalenol after 3 wk of continuous feeding of this mycotoxin at concentrations of 2.44 +/- 0.70 mg/kg of feed and 7.54 +/- 2.20 mg/kg of feed in broilers. This correlates with the poor absorption of deoxynivalenol in poultry. A safety study with 2 commercially available detoxifying agents and veterinary drugs showed innovative results with regard to the pharmacokinetics of 2 antibiotics after oral dosing in the drinking water. The plasma and kidney tissue concentrations of oxytetracycline were significantly higher in broilers receiving a biotransforming agent in the feed compared with control birds. For amoxicillin, the plasma concentrations were significantly higher for broilers receiving an adsorbing agent in comparison to birds receiving the biotransforming agent, but not to the control group. Mycotoxin-detoxifying agents can thus interact with the oral bioavailability of antibiotics depending on the antibiotic and detoxifying agent, with possible adverse effects on the health of animals and humans.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FUSARIUM MYCOTOXINS, ADSORBENT MATERIALS, QUANTITATIVE-DETERMINATION, TOXIN-CONTAMINATED WHEAT, TANDEM MASS-SPECTROMETRY, broiler, efficacy and safety testing, detoxifying agent, antibiotic, deoxynivalenol, FEED ADDITIVES, DEOXYNIVALENOL, IN-VITRO, T-2 TOXIN, PIG-TISSUES
journal title
POULTRY SCIENCE
Poult. Sci.
volume
91
issue
8
pages
2046 - 2054
Web of Science type
Article
Web of Science id
000306719800041
JCR category
AGRICULTURE, DAIRY & ANIMAL SCIENCE
JCR impact factor
1.516 (2012)
JCR rank
11/54 (2012)
JCR quartile
1 (2012)
ISSN
0032-5791
DOI
10.3382/ps.2012-02245
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2966137
handle
http://hdl.handle.net/1854/LU-2966137
date created
2012-07-31 16:09:49
date last changed
2014-02-19 11:07:35
@article{2966137,
  abstract     = {Contamination of feeds with mycotoxins is a worldwide problem and mycotoxin-detoxifying agents are used to decrease their negative effect. The European Food Safety Authority recently stated guidelines and end-points for the efficacy testing of detoxifiers. Our study revealed that plasma concentrations of deoxynivalenol and deepoxy-deoxynivalenol were too low to assess efficacy of 2 commercially available mycotoxin-detoxifying agents against deoxynivalenol after 3 wk of continuous feeding of this mycotoxin at concentrations of 2.44 +/- 0.70 mg/kg of feed and 7.54 +/- 2.20 mg/kg of feed in broilers. This correlates with the poor absorption of deoxynivalenol in poultry. A safety study with 2 commercially available detoxifying agents and veterinary drugs showed innovative results with regard to the pharmacokinetics of 2 antibiotics after oral dosing in the drinking water. The plasma and kidney tissue concentrations of oxytetracycline were significantly higher in broilers receiving a biotransforming agent in the feed compared with control birds. For amoxicillin, the plasma concentrations were significantly higher for broilers receiving an adsorbing agent in comparison to birds receiving the biotransforming agent, but not to the control group. Mycotoxin-detoxifying agents can thus interact with the oral bioavailability of antibiotics depending on the antibiotic and detoxifying agent, with possible adverse effects on the health of animals and humans.},
  author       = {Osselaere, Ann and Devreese, Mathias and Watteyn, Anneleen and Vandenbroucke, Virginie and Goossens, Joline and Hautekiet, Veerle  and Eeckhout, Mia and De Saeger, Sarah and De Baere, Siegrid and De Backer, Patrick and Croubels, Siska},
  issn         = {0032-5791},
  journal      = {POULTRY SCIENCE},
  keyword      = {FUSARIUM MYCOTOXINS,ADSORBENT MATERIALS,QUANTITATIVE-DETERMINATION,TOXIN-CONTAMINATED WHEAT,TANDEM MASS-SPECTROMETRY,broiler,efficacy and safety testing,detoxifying agent,antibiotic,deoxynivalenol,FEED ADDITIVES,DEOXYNIVALENOL,IN-VITRO,T-2 TOXIN,PIG-TISSUES},
  language     = {eng},
  number       = {8},
  pages        = {2046--2054},
  title        = {Efficacy and safety testing of mycotocoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines},
  url          = {http://dx.doi.org/10.3382/ps.2012-02245},
  volume       = {91},
  year         = {2012},
}

Chicago
Osselaere, Ann, Mathias Devreese, Anneleen Watteyn, Virginie Vandenbroucke, Joline Goossens, Veerle Hautekiet, Mia Eeckhout, et al. 2012. “Efficacy and Safety Testing of Mycotocoxin-detoxifying Agents in Broilers Following the European Food Safety Authority Guidelines.” Poultry Science 91 (8): 2046–2054.
APA
Osselaere, A., Devreese, M., Watteyn, A., Vandenbroucke, V., Goossens, J., Hautekiet, V., Eeckhout, M., et al. (2012). Efficacy and safety testing of mycotocoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. POULTRY SCIENCE, 91(8), 2046–2054.
Vancouver
1.
Osselaere A, Devreese M, Watteyn A, Vandenbroucke V, Goossens J, Hautekiet V, et al. Efficacy and safety testing of mycotocoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. POULTRY SCIENCE. 2012;91(8):2046–54.
MLA
Osselaere, Ann, Mathias Devreese, Anneleen Watteyn, et al. “Efficacy and Safety Testing of Mycotocoxin-detoxifying Agents in Broilers Following the European Food Safety Authority Guidelines.” POULTRY SCIENCE 91.8 (2012): 2046–2054. Print.