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Tissue Doppler imaging and two-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid

Annelies Decloedt UGent, Tinne Verheyen UGent, Stanislas Sys UGent, Dominique De Clercq UGent and Gunther van Loon UGent (2012) JOURNAL OF VETERINARY INTERNAL MEDICINE. 26(5). p.1209-1216
abstract
Background: Tissue Doppler imaging (TDI) and two-dimensional speckle tracking (2DST) can quantify left ventricular (LV) function in horses. Objectives: To evaluate LV function by TDI and 2DST in horses with myocardial dysfunction after accidental ionophore intoxication. Animals: Sixty-seven horses exposed to lasalocid in feed. Methods: Prospective study. Horses were included in the study if a full cardiac examination was performed, consisting of determination of cardiac troponin I (cTnI), electrocardiography and echocardiography. By TDI, radial systolic velocity and strain were measured. By 2DST, circumferential (SC) and radial (SR) strain at papillary muscle and chordal level and longitudinal (SL) strain were measured. Results: Twenty horses showed signs of myocardial injury. Forty-nine examinations were performed on these horses between day 30 and 490 after suspected onset of exposure. Five horses had increased cTnI and ventricular tachycardia and fifteen increased cTnI without ventricular tachycardia. Horses with mild myocardial damage showed few significant differences compared to a control group. Horses with severe myocardial damage showed severely decreased TDI, 2DST and fractional shortening measurements (P<0.05), indicating impaired LV function. Long-term follow-up of two surviving horses demonstrated full recovery in one horse and permanent myocardial fibrosis in the other. The lowest measurements per horse (n=20) for all TDI measurements, SL, SR at chordal level and FS correlated significantly with maximal cTnI (P<0.05). Over all examinations (n=49), TDI and 2DST measurements correlated well with FS (P<0.05). Conclusions and clinical importance: TDI and 2DST measurements allowed accurate detection and quantification of LV dysfunction in horses exposed to lasalocid.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
myocardial function, strain, intoxication, echocardiography, ionophore, CARDIAC TROPONIN-I, ATRIAL-FIBRILLATION, MYOCARDIAL DYSFUNCTION, CLINICAL-APPLICATIONS, MONENSIN TOXICOSIS, HEALTHY HORSES, WALL-MOTION, STRAIN-RATE, M-MODE, ECHOCARDIOGRAPHY
journal title
JOURNAL OF VETERINARY INTERNAL MEDICINE
J. Vet. Intern. Med.
volume
26
issue
5
pages
1209 - 1216
Web of Science type
Article
Web of Science id
000308875500020
JCR category
VETERINARY SCIENCES
JCR impact factor
2.064 (2012)
JCR rank
13/142 (2012)
JCR quartile
1 (2012)
ISSN
0891-6640
DOI
10.1111/j.1939-1676.2012.00972.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2965898
handle
http://hdl.handle.net/1854/LU-2965898
date created
2012-07-31 10:49:25
date last changed
2013-07-05 16:54:14
@article{2965898,
  abstract     = {Background: Tissue Doppler imaging (TDI) and two-dimensional speckle tracking (2DST) can quantify left ventricular (LV) function in horses.
Objectives: To evaluate LV function by TDI and 2DST in horses with myocardial dysfunction after accidental ionophore intoxication.
Animals: Sixty-seven horses exposed to lasalocid in feed. 
Methods: Prospective study. Horses were included in the study if a full cardiac examination was performed, consisting of determination of cardiac troponin I (cTnI), electrocardiography and echocardiography. By TDI, radial systolic velocity and strain were measured. By 2DST, circumferential (SC) and radial (SR) strain at papillary muscle and chordal level and longitudinal (SL) strain were measured.
Results: Twenty horses showed signs of myocardial injury. Forty-nine examinations were performed on these horses between day 30 and 490 after suspected onset of exposure. Five horses had increased cTnI and ventricular tachycardia and fifteen increased cTnI without ventricular tachycardia. Horses with mild myocardial damage showed few significant differences compared to a control group. Horses with severe myocardial damage showed severely decreased TDI, 2DST and fractional shortening measurements (P{\textlangle}0.05), indicating impaired LV function. Long-term follow-up of two surviving horses demonstrated full recovery in one horse and permanent myocardial fibrosis in the other. The lowest measurements per horse (n=20) for all TDI measurements, SL, SR at chordal level and FS correlated significantly with maximal cTnI (P{\textlangle}0.05). Over all examinations (n=49), TDI and 2DST measurements correlated well with FS (P{\textlangle}0.05).
Conclusions and clinical importance: TDI and 2DST measurements allowed accurate detection and quantification of LV dysfunction in horses exposed to lasalocid.},
  author       = {Decloedt, Annelies and Verheyen, Tinne and Sys, Stanislas and De Clercq, Dominique and van Loon, Gunther},
  issn         = {0891-6640},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keyword      = {myocardial function,strain,intoxication,echocardiography,ionophore,CARDIAC TROPONIN-I,ATRIAL-FIBRILLATION,MYOCARDIAL DYSFUNCTION,CLINICAL-APPLICATIONS,MONENSIN TOXICOSIS,HEALTHY HORSES,WALL-MOTION,STRAIN-RATE,M-MODE,ECHOCARDIOGRAPHY},
  language     = {eng},
  number       = {5},
  pages        = {1209--1216},
  title        = {Tissue Doppler imaging and two-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid},
  url          = {http://dx.doi.org/10.1111/j.1939-1676.2012.00972.x},
  volume       = {26},
  year         = {2012},
}

Chicago
Decloedt, Annelies, Tinne Verheyen, Stanislas Sys, Dominique De Clercq, and Gunther van Loon. 2012. “Tissue Doppler Imaging and Two-dimensional Speckle Tracking of Left Ventricular Function in Horses Exposed to Lasalocid.” Journal of Veterinary Internal Medicine 26 (5): 1209–1216.
APA
Decloedt, A., Verheyen, T., Sys, S., De Clercq, D., & van Loon, G. (2012). Tissue Doppler imaging and two-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(5), 1209–1216.
Vancouver
1.
Decloedt A, Verheyen T, Sys S, De Clercq D, van Loon G. Tissue Doppler imaging and two-dimensional speckle tracking of left ventricular function in horses exposed to lasalocid. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2012;26(5):1209–16.
MLA
Decloedt, Annelies, Tinne Verheyen, Stanislas Sys, et al. “Tissue Doppler Imaging and Two-dimensional Speckle Tracking of Left Ventricular Function in Horses Exposed to Lasalocid.” JOURNAL OF VETERINARY INTERNAL MEDICINE 26.5 (2012): 1209–1216. Print.