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Genetic framework of cyclin-dependent kinase function in Arabidopsis

Moritz Nowack UGent, Hirofumi Harashima, Nico Dissmeyer, Xin'Ai Zhao, Daniel Bouyer, Annika K Weimer, Freya De Winter UGent, Fang Yang and Arp Schnittger (2012) DEVELOPMENTAL CELL. 22(5). p.1030-1040
abstract
Cyclin-dependent kinases (CDKs) are at the heart of eukaryotic cell-cycle control. The yeast Cdc2/CDC28 PSTAIRE kinase and its orthologs such as the mammalian Cdk1 have been found to be indispensable for cell-cycle progression in all eukaryotes investigated so far. CDKA;1 is the only PSTAIRE kinase in the flowering plant Arabidopsis and can rescue Cdc2/CDC28 mutants. Here, we show that cdka;1 null mutants are viable but display specific cell-cycle and developmental defects, e.g., in S phase entry and stem cell maintenance. We unravel that the crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and that codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants. Our work further revealed a basic cell-cycle control system relying on two plant-specific B1-type CDKs, and the triple cdk mutants displayed an early germline arrest. Taken together, our data indicate divergent functional differentiation of Cdc2-type kinases during eukaryote evolution.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CDK1, CDC2, THALIANA, PROLIFERATION, FISSION YEAST, RETINOBLASTOMA PROTEIN, MAMMALIAN-CELL-CYCLE, FEMALE GAMETOPHYTE, PHOSPHORYLATION, DIVISION
journal title
DEVELOPMENTAL CELL
Dev. Cell
volume
22
issue
5
pages
1030 - 1040
Web of Science type
Article
Web of Science id
000304291700015
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
12.861 (2012)
JCR rank
2/41 (2012)
JCR quartile
1 (2012)
ISSN
1534-5807
DOI
10.1016/j.devcel.2012.02.015
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2965070
handle
http://hdl.handle.net/1854/LU-2965070
date created
2012-07-30 13:30:10
date last changed
2016-12-19 15:42:25
@article{2965070,
  abstract     = {Cyclin-dependent kinases (CDKs) are at the heart of eukaryotic cell-cycle control. The yeast Cdc2/CDC28 PSTAIRE kinase and its orthologs such as the mammalian Cdk1 have been found to be indispensable for cell-cycle progression in all eukaryotes investigated so far. CDKA;1 is the only PSTAIRE kinase in the flowering plant Arabidopsis and can rescue Cdc2/CDC28 mutants. Here, we show that cdka;1 null mutants are viable but display specific cell-cycle and developmental defects, e.g., in S phase entry and stem cell maintenance. We unravel that the crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and that codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants. Our work further revealed a basic cell-cycle control system relying on two plant-specific B1-type CDKs, and the triple cdk mutants displayed an early germline arrest. Taken together, our data indicate divergent functional differentiation of Cdc2-type kinases during eukaryote evolution.},
  author       = {Nowack, Moritz and Harashima, Hirofumi and Dissmeyer, Nico and Zhao, Xin'Ai and Bouyer, Daniel and Weimer, Annika K and De Winter, Freya and Yang, Fang and Schnittger, Arp},
  issn         = {1534-5807},
  journal      = {DEVELOPMENTAL CELL},
  keyword      = {CDK1,CDC2,THALIANA,PROLIFERATION,FISSION YEAST,RETINOBLASTOMA PROTEIN,MAMMALIAN-CELL-CYCLE,FEMALE GAMETOPHYTE,PHOSPHORYLATION,DIVISION},
  language     = {eng},
  number       = {5},
  pages        = {1030--1040},
  title        = {Genetic framework of cyclin-dependent kinase function in Arabidopsis},
  url          = {http://dx.doi.org/10.1016/j.devcel.2012.02.015},
  volume       = {22},
  year         = {2012},
}

Chicago
Nowack, Moritz, Hirofumi Harashima, Nico Dissmeyer, Xin’Ai Zhao, Daniel Bouyer, Annika K Weimer, Freya De Winter, Fang Yang, and Arp Schnittger. 2012. “Genetic Framework of Cyclin-dependent Kinase Function in Arabidopsis.” Developmental Cell 22 (5): 1030–1040.
APA
Nowack, M., Harashima, H., Dissmeyer, N., Zhao, X., Bouyer, D., Weimer, A. K., De Winter, F., et al. (2012). Genetic framework of cyclin-dependent kinase function in Arabidopsis. DEVELOPMENTAL CELL, 22(5), 1030–1040.
Vancouver
1.
Nowack M, Harashima H, Dissmeyer N, Zhao X, Bouyer D, Weimer AK, et al. Genetic framework of cyclin-dependent kinase function in Arabidopsis. DEVELOPMENTAL CELL. 2012;22(5):1030–40.
MLA
Nowack, Moritz, Hirofumi Harashima, Nico Dissmeyer, et al. “Genetic Framework of Cyclin-dependent Kinase Function in Arabidopsis.” DEVELOPMENTAL CELL 22.5 (2012): 1030–1040. Print.