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DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity

Hannes Claeys UGent, Aleksandra Skirycz UGent, Katrien Maleux UGent and Dirk Inzé UGent (2012) PLANT PHYSIOLOGY. 159(2). p.739-747
abstract
Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have developed unique mechanisms to respond to stress. Previously, we studied the effects of osmotic stress on dividing leaf cells in Arabidopsis (Arabidopsis thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division and start endoreduplication earlier. In this study, we analyzed this phenomenon in more detail. Osmotic stress induces changes in gibberellin metabolism, resulting in the stabilization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication. Consequently, this response is absent in mutants with altered gibberellin levels or DELLA activity. Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GIBBERELLIN-INDUCED DEGRADATION, SEED-GERMINATION, LEAF DEVELOPMENT, KINASE INHIBITOR, ENDOCYCLE ONSET, PROTEIN-KINASE, WATER-DEFICIT, GROWTH, CYCLE, THALIANA
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
159
issue
2
pages
739 - 747
Web of Science type
Article
Web of Science id
000304834800017
JCR category
PLANT SCIENCES
JCR impact factor
6.555 (2012)
JCR rank
8/193 (2012)
JCR quartile
1 (2012)
ISSN
0032-0889
DOI
10.1104/pp.112.195032
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2964768
handle
http://hdl.handle.net/1854/LU-2964768
date created
2012-07-30 11:26:08
date last changed
2014-05-26 10:03:54
@article{2964768,
  abstract     = {Drought is responsible for considerable yield losses in agriculture due to its detrimental effects on growth. Drought responses have been extensively studied, but mostly on the level of complete plants or mature tissues. However, stress responses were shown to be highly tissue and developmental stage specific, and dividing tissues have developed unique mechanisms to respond to stress. Previously, we studied the effects of osmotic stress on dividing leaf cells in Arabidopsis (Arabidopsis thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division and start endoreduplication earlier. In this study, we analyzed this phenomenon in more detail. Osmotic stress induces changes in gibberellin metabolism, resulting in the stabilization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication. Consequently, this response is absent in mutants with altered gibberellin levels or DELLA activity. Mitotic exit and onset of endoreduplication do not correlate with an up-regulation of known cell cycle inhibitors but are the result of reduced levels of DP-E2F-LIKE1/E2Fe and UV-B-INSENSITIVE4, both inhibitors of the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting complex/cyclosome activity, which are down-regulated rapidly after DELLA stabilization. This work fits into an emerging view of DELLAs as regulators of cell division by regulating the transition to endoreduplication and differentiation.},
  author       = {Claeys, Hannes and Skirycz, Aleksandra and Maleux, Katrien and Inz{\'e}, Dirk},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {GIBBERELLIN-INDUCED DEGRADATION,SEED-GERMINATION,LEAF DEVELOPMENT,KINASE INHIBITOR,ENDOCYCLE ONSET,PROTEIN-KINASE,WATER-DEFICIT,GROWTH,CYCLE,THALIANA},
  language     = {eng},
  number       = {2},
  pages        = {739--747},
  title        = {DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity},
  url          = {http://dx.doi.org/10.1104/pp.112.195032},
  volume       = {159},
  year         = {2012},
}

Chicago
Claeys, Hannes, Aleksandra Skirycz, Katrien Maleux, and Dirk Inzé. 2012. “DELLA Signaling Mediates Stress-induced Cell Differentiation in Arabidopsis Leaves Through Modulation of Anaphase-promoting Complex/cyclosome Activity.” Plant Physiology 159 (2): 739–747.
APA
Claeys, H., Skirycz, A., Maleux, K., & Inzé, D. (2012). DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity. PLANT PHYSIOLOGY, 159(2), 739–747.
Vancouver
1.
Claeys H, Skirycz A, Maleux K, Inzé D. DELLA signaling mediates stress-induced cell differentiation in Arabidopsis leaves through modulation of anaphase-promoting complex/cyclosome activity. PLANT PHYSIOLOGY. 2012;159(2):739–47.
MLA
Claeys, Hannes, Aleksandra Skirycz, Katrien Maleux, et al. “DELLA Signaling Mediates Stress-induced Cell Differentiation in Arabidopsis Leaves Through Modulation of Anaphase-promoting Complex/cyclosome Activity.” PLANT PHYSIOLOGY 159.2 (2012): 739–747. Print.