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How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder

Mieke Dereu (UGent) , Herbert Roeyers (UGent) , Ruth Raymaekers (UGent) , Mieke Meirsschaut (UGent) and Petra Warreyn (UGent)
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Abstract
Screening instruments for autism spectrum disorder (ASD) often generate many false positives. It is argued that these children may have other developmental difficulties and are also in need of thorough assessment and early intervention. The current study looked at the predictive validity of positive screens on the Checklist for Early Signs of Developmental Disorders (CESDD) and the Early Screening of Autistic Traits questionnaire (ESAT) at age 2 towards language, cognitive function, and symptom severity at age 4. Children who screened positive on the ESAT scored lower for both language and cognitive functioning at age 4 compared with children who screened negative on the ESAT. Also, the more signs of ASD that were recognized on the CESDD or ESAT, the lower the scores for language and cognitive functioning at age 4. False positive screens could be differentiated from true positive screens on the CESDD only in symptom severity score on the Autism Diagnostic Observation Schedule (ADOS). It seems that early screeners for ASD also detect children with other developmental disorders and that diagnostic instruments such as the ADOS are warranted to differentiate between children with ASD and other developmental problems.
Keywords
DIAGNOSTIC-OBSERVATION-SCHEDULE, TRAITS QUESTIONNAIRE ESAT, MODIFIED CHECKLIST, REVISED ALGORITHMS, ADOS SCORES, POPULATION, VALIDITY, SIGNS, CHAT, Autism spectrum disorder, Screening, Toddlers, Language, General development, Symptom severity

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Chicago
Dereu, Mieke, Herbert Roeyers, Ruth Raymaekers, Mieke Meirsschaut, and Petra Warreyn. 2012. “How Useful Are Screening Instruments for Toddlers to Predict Outcome at Age 4? General Development, Language Skills, and Symptom Severity in Children with a False Positive Screen for Autism Spectrum Disorder.” European Child & Adolescent Psychiatry 21 (10): 541–551.
APA
Dereu, M., Roeyers, H., Raymaekers, R., Meirsschaut, M., & Warreyn, P. (2012). How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 21(10), 541–551.
Vancouver
1.
Dereu M, Roeyers H, Raymaekers R, Meirsschaut M, Warreyn P. How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2012;21(10):541–51.
MLA
Dereu, Mieke, Herbert Roeyers, Ruth Raymaekers, et al. “How Useful Are Screening Instruments for Toddlers to Predict Outcome at Age 4? General Development, Language Skills, and Symptom Severity in Children with a False Positive Screen for Autism Spectrum Disorder.” EUROPEAN CHILD & ADOLESCENT PSYCHIATRY 21.10 (2012): 541–551. Print.
@article{2958401,
  abstract     = {Screening instruments for autism spectrum disorder (ASD) often generate many false positives. It is argued that these children may have other developmental difficulties and are also in need of thorough assessment and early intervention. The current study looked at the predictive validity of positive screens on the Checklist for Early Signs of Developmental Disorders (CESDD) and the Early Screening of Autistic Traits questionnaire (ESAT) at age 2 towards language, cognitive function, and symptom severity at age 4. Children who screened positive on the ESAT scored lower for both language and cognitive functioning at age 4 compared with children who screened negative on the ESAT. Also, the more signs of ASD that were recognized on the CESDD or ESAT, the lower the scores for language and cognitive functioning at age 4. False positive screens could be differentiated from true positive screens on the CESDD only in symptom severity score on the Autism Diagnostic Observation Schedule (ADOS). It seems that early screeners for ASD also detect children with other developmental disorders and that diagnostic instruments such as the ADOS are warranted to differentiate between children with ASD and other developmental problems.},
  author       = {Dereu, Mieke and Roeyers, Herbert and Raymaekers, Ruth and Meirsschaut, Mieke and Warreyn, Petra},
  issn         = {1018-8827},
  journal      = {EUROPEAN CHILD \& ADOLESCENT PSYCHIATRY},
  language     = {eng},
  number       = {10},
  pages        = {541--551},
  title        = {How useful are screening instruments for toddlers to predict outcome at age 4? General development, language skills, and symptom severity in children with a false positive screen for autism spectrum disorder},
  url          = {http://dx.doi.org/10.1007/s00787-012-0280-y},
  volume       = {21},
  year         = {2012},
}

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