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Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection

Miet De Baere UGent (2012)
abstract
In 1985, sialoadhesin (Siglec-1, CD169) was first described as a non-phagocytic sheep erythrocyte receptor (SER) expressed on resident bone marrow macrophages. A lot has been learned since then, and sialoadhesin is now established as a sialic-acid binding immunoglobulin-like lectin (Siglec) which is only expressed on subsets of differentiated macrophages and on inflammatory monocytes and macrophages. Besides being involved in cell-cell and cell-matrix interactions, sialoadhesin can also bind several pathogens. The receptor is involved in the entry of Neisseria meningitides, and serves as an endocytic receptor for porcine reproductive and respiratory syndrome virus (PRRSV). Despite continuing research efforts, the physiological role of sialoadhesin remains unclear up until today. Several studies indicate that the receptor may play a role in antigen presentation, and may be involved in the regulation of T cell responses in disease settings. Currently, a lot of effort is being made at developing therapies that can specifically target macrophages. The recognition of sialoadhesin as an endocytic receptor prompted interest in this molecule as a target for macrophagedirected therapies, which was further supported by its restricted expression pattern and the absence of a soluble form. However, the effect of ligation of sialoadhesin on macrophage functioning is poorly studied, even though it might provide valuable insights in the physiological function of sialoadhesin, as well as indicate possible side effects of sialoadhesin-targeted therapies
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author
promoter
UGent and UGent
organization
alternative title
Nieuwe inzichten in de fysiologische functie van sialoadhesine als een downregulator van fagocytose door macrofagen en de invloed op virale infectie
year
type
dissertation (monograph)
subject
keyword
PRRSV
pages
VII, 156 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium hoogbouw)
defense date
2012-06-27 17:00
ISBN
9789058643025
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
2956735
handle
http://hdl.handle.net/1854/LU-2956735
date created
2012-07-05 16:08:10
date last changed
2012-07-06 08:44:56
@phdthesis{2956735,
  abstract     = {In 1985, sialoadhesin (Siglec-1, CD169) was first described as a non-phagocytic sheep erythrocyte receptor (SER) expressed on resident bone marrow macrophages. A lot has been learned since then, and sialoadhesin is now established as a sialic-acid binding immunoglobulin-like lectin (Siglec) which is only expressed on subsets of differentiated macrophages and on inflammatory monocytes and macrophages. Besides being involved in cell-cell and cell-matrix interactions, sialoadhesin can also bind several pathogens. The receptor is involved in the entry of Neisseria meningitides, and serves as an endocytic receptor for porcine reproductive and respiratory syndrome virus (PRRSV). Despite continuing research efforts, the physiological role of sialoadhesin remains unclear up until today.
Several studies indicate that the receptor may play a role in antigen presentation, and may be involved in the regulation of T cell responses in disease settings. Currently, a lot of effort is being made at developing therapies that can specifically target macrophages. The recognition of sialoadhesin as an endocytic receptor prompted interest in this molecule as a target for macrophagedirected therapies, which was further supported by its restricted expression pattern and the absence of a soluble form. However, the effect of ligation of sialoadhesin on macrophage functioning is poorly studied, even though it might provide valuable insights in the physiological function of sialoadhesin, as well as indicate possible side effects of sialoadhesin-targeted therapies},
  author       = {De Baere, Miet},
  isbn         = {9789058643025},
  keyword      = {PRRSV},
  language     = {eng},
  pages        = {VII, 156},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection},
  year         = {2012},
}

Chicago
De Baere, Miet. 2012. “Novel Insights in the Physiological Function of Sialoadhesin as a Downregulator of Macrophage Phagocytosis and Its Implications for Viral Infection”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
De Baere, M. (2012). Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
De Baere M. Novel insights in the physiological function of sialoadhesin as a downregulator of macrophage phagocytosis and its implications for viral infection. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2012.
MLA
De Baere, Miet. “Novel Insights in the Physiological Function of Sialoadhesin as a Downregulator of Macrophage Phagocytosis and Its Implications for Viral Infection.” 2012 : n. pag. Print.