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Antigenic characterisation of porcine circovirus 2 strains and outcome of experimental porcine circovirus 1 and 2 infections in porcine foetuses and in pigs

Dipongkor Saha UGent (2012)
abstract
Porcine circoviruses (PCV1 and PCV2) are ubiquitious around the world. Although the genetic diversity among the PCV2 strains has been extensively studied, the antigenic diversity has been much less explored. PCV1 has been isolated from cases of reproductive failure and congenital tremor in newborn pigs. PCV2 is associated with Postweaning Multisystemic Wasting Syndrome (PMWS) and can cause reproductive failure. Despite the isolation of PCV1 and PCV2 from aborted/stillborn piglets and from cases of congenital tremors in newborn piglets, nothing is known about the outcome of experimental PCV1 infections in porcine foetuses and the outcome of experimental PCV2 (PCV2a or PCV2b) infections in porcine foetuses has only been examined with a restricted number of strains. The pathogenesis of PMWS is not fully understood yet and further research is needed. The absence or presence of low levels of neutralising antibodies in PMWS pigs has been reported and it may be hypothesized that this could be due to a certain immunotolerance upon an intrauterine infection with a less virulent PCV2 strain.
Please use this url to cite or link to this publication:
author
promoter
UGent
organization
year
type
dissertation (monograph)
subject
keyword
Porcine Foetus, PMWS, PCV1, PCV2
pages
181 pages
publisher
Ghent University. Faculty of Veterinary Medicine
place of publication
Merelbeke, Belgium
defense location
Merelbeke : Faculteit Diergeneeskunde (auditorium hoogbouw)
defense date
2012-06-21 17:00
ISBN
9789058642943
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have retained and own the full copyright for this publication
id
2956732
handle
http://hdl.handle.net/1854/LU-2956732
date created
2012-07-05 16:03:28
date last changed
2012-07-06 08:29:32
@phdthesis{2956732,
  abstract     = {Porcine circoviruses (PCV1 and PCV2) are ubiquitious around the world. Although the genetic diversity among the PCV2 strains has been extensively studied, the antigenic diversity has been much less explored. PCV1 has been isolated from cases of reproductive failure and congenital tremor in newborn pigs. PCV2 is associated with Postweaning Multisystemic Wasting Syndrome (PMWS) and can cause reproductive failure. Despite the isolation of PCV1 and PCV2 from aborted/stillborn piglets and from cases of congenital tremors in newborn piglets, nothing is known about the outcome of experimental PCV1 infections in porcine foetuses and the outcome of experimental PCV2 (PCV2a or PCV2b) infections in porcine foetuses has only been examined with a restricted number of strains. The pathogenesis of PMWS is not fully understood yet and further research is needed. The absence or presence of low levels of neutralising antibodies in PMWS pigs has been reported and it may be hypothesized that this could be due to a certain immunotolerance upon an intrauterine infection with a less virulent PCV2 strain.},
  author       = {Saha, Dipongkor},
  isbn         = {9789058642943},
  keyword      = {Porcine Foetus,PMWS,PCV1,PCV2},
  language     = {eng},
  pages        = {181},
  publisher    = {Ghent University. Faculty of Veterinary Medicine},
  school       = {Ghent University},
  title        = {Antigenic characterisation of porcine circovirus 2 strains and outcome of experimental porcine circovirus 1 and 2 infections in porcine foetuses and in pigs},
  year         = {2012},
}

Chicago
Saha, Dipongkor. 2012. “Antigenic Characterisation of Porcine Circovirus 2 Strains and Outcome of Experimental Porcine Circovirus 1 and 2 Infections in Porcine Foetuses and in Pigs”. Merelbeke, Belgium: Ghent University. Faculty of Veterinary Medicine.
APA
Saha, D. (2012). Antigenic characterisation of porcine circovirus 2 strains and outcome of experimental porcine circovirus 1 and 2 infections in porcine foetuses and in pigs. Ghent University. Faculty of Veterinary Medicine, Merelbeke, Belgium.
Vancouver
1.
Saha D. Antigenic characterisation of porcine circovirus 2 strains and outcome of experimental porcine circovirus 1 and 2 infections in porcine foetuses and in pigs. [Merelbeke, Belgium]: Ghent University. Faculty of Veterinary Medicine; 2012.
MLA
Saha, Dipongkor. “Antigenic Characterisation of Porcine Circovirus 2 Strains and Outcome of Experimental Porcine Circovirus 1 and 2 Infections in Porcine Foetuses and in Pigs.” 2012 : n. pag. Print.