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Intercellular Ca2+ waves: mechanisms and functions

Luc Leybaert UGent and Michael J Sanderson (2012) PHYSIOLOGICAL REVIEWS. 92(3). p.1359-1392
abstract
Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of cells and have been extensively studied in vitro. More recent studies focus on ICWs in vivo. ICWs are triggered by a variety of stimuli and involve the release of Ca2+ from internal stores. The propagation of ICWs predominately involves cell communication with internal messengers moving via gap junctions or extracellular messengers mediating paracrine signaling. ICWs appear to be important in both normal physiology as well as pathophysiological processes in a variety of organs and tissues including brain, liver, retina, cochlea, and vascular tissue. We review here the mechanisms of initiation and propagation of ICWs, the key intra-and extracellular messengers (inositol 1,4,5-trisphosphate and ATP) mediating ICWs, and the proposed physiological functions of ICWs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
CONNEXIN-MIMETIC PEPTIDES, GAP-JUNCTION CHANNELS, SMOOTH-MUSCLE-CELLS, CYCLIC ADP-RIBOSE, INOSITOL 1, 4, 5-TRISPHOSPHATE RECEPTOR, AIRWAY EPITHELIAL-CELLS, CORNEAL ENDOTHELIAL-CELLS, ASTROCYTE CALCIUM WAVES, HIPPOCAMPAL ASTROGLIAL CELLS, THROMBIN-INDUCED INHIBITION
journal title
PHYSIOLOGICAL REVIEWS
Physiol. Rev.
volume
92
issue
3
pages
1359 - 1392
Web of Science type
Review
Web of Science id
000306566500008
JCR category
PHYSIOLOGY
JCR impact factor
30.174 (2012)
JCR rank
1/79 (2012)
JCR quartile
1 (2012)
ISSN
0031-9333
DOI
10.1152/physrev.00029.2011
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2950374
handle
http://hdl.handle.net/1854/LU-2950374
date created
2012-06-30 12:06:14
date last changed
2012-09-03 13:39:28
@article{2950374,
  abstract     = {Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism for coordinating multicellular responses. ICWs occur in a wide diversity of cells and have been extensively studied in vitro. More recent studies focus on ICWs in vivo. ICWs are triggered by a variety of stimuli and involve the release of Ca2+ from internal stores. The propagation of ICWs predominately involves cell communication with internal messengers moving via gap junctions or extracellular messengers mediating paracrine signaling. ICWs appear to be important in both normal physiology as well as pathophysiological processes in a variety of organs and tissues including brain, liver, retina, cochlea, and vascular tissue. We review here the mechanisms of initiation and propagation of ICWs, the key intra-and extracellular messengers (inositol 1,4,5-trisphosphate and ATP) mediating ICWs, and the proposed physiological functions of ICWs.},
  author       = {Leybaert, Luc and Sanderson, Michael J},
  issn         = {0031-9333},
  journal      = {PHYSIOLOGICAL REVIEWS},
  keyword      = {CONNEXIN-MIMETIC PEPTIDES,GAP-JUNCTION CHANNELS,SMOOTH-MUSCLE-CELLS,CYCLIC ADP-RIBOSE,INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR,AIRWAY EPITHELIAL-CELLS,CORNEAL ENDOTHELIAL-CELLS,ASTROCYTE CALCIUM WAVES,HIPPOCAMPAL ASTROGLIAL CELLS,THROMBIN-INDUCED INHIBITION},
  language     = {eng},
  number       = {3},
  pages        = {1359--1392},
  title        = {Intercellular Ca2+ waves: mechanisms and functions},
  url          = {http://dx.doi.org/10.1152/physrev.00029.2011},
  volume       = {92},
  year         = {2012},
}

Chicago
Leybaert, Luc, and Michael J Sanderson. 2012. “Intercellular Ca2+ Waves: Mechanisms and Functions.” Physiological Reviews 92 (3): 1359–1392.
APA
Leybaert, L., & Sanderson, M. J. (2012). Intercellular Ca2+ waves: mechanisms and functions. PHYSIOLOGICAL REVIEWS, 92(3), 1359–1392.
Vancouver
1.
Leybaert L, Sanderson MJ. Intercellular Ca2+ waves: mechanisms and functions. PHYSIOLOGICAL REVIEWS. 2012;92(3):1359–92.
MLA
Leybaert, Luc, and Michael J Sanderson. “Intercellular Ca2+ Waves: Mechanisms and Functions.” PHYSIOLOGICAL REVIEWS 92.3 (2012): 1359–1392. Print.