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Antimicrobial and antioxidative effects of Ugandan medicinal barks

Marta Kuglerova, Hana Tesarova, Jean Grade UGent, Katerina Halamova, Olivia Wanyana-Maganyi, Patrick Van Damme UGent and Ladislav Kokoska (2011) AFRICAN JOURNAL OF BIOTECHNOLOGY. 10(18). p.3628-3632
abstract
Despite a rich tradition of medicinal plants use by local communities in Uganda their direct antimicrobial effectives together with potential to protect human health against diseases induced by oxidative stress are still poorly documented. The aim of this study is to investigate the in vitro antimicrobial and total antioxidative activities of barks from five tree species selected using information on their traditional use by Karamojong healers in Uganda. The antimicrobial activity of crude ethanol extracts of Fagaropsis angolensis (Engl.) H. M. Gardener (Rutaceae), Trichilia prieuriana A. Juss. (Meliaceae), Turraea floribunda Hochst. (Meliaceae), Warburgia salutaris Sprague (Canellaeceae) and Zanthoxylum chalybeum Engl. (Rutaceae) were tested against four bacteria and one yeast species using the broth microdilution method. The total antioxidative activity was determined by 2,2-diphenyl-1-picrylhydrazil free radical scavenging assay. It was found that the extract of F. angolensis possess the strongest antimicrobial activity inhibiting growth of Staphylococcus aureus and Candida albicans with minimum inhibitory concentrations of 64 and 32 mu g/ml, respectively. Among all plants tested, W. salutaris showed the most promising antioxidative properties (IC(50) = 6.59 mu g/ml). As a result of this study, F. angolensis and W. salutaris possessed significant antimicrobial and antioxidative effects which indicates prospective pharmacological properties of both species.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
UGANDENSIS, PLANTS, SESQUITERPENES, AFRICA, TREE, ANTIMYCOBACTERIAL ACTIVITY, medicinal plants, Uganda, WARBURGIA-SALUTARIS, Antimicrobial activity, total antioxidative activity, crude extracts
journal title
AFRICAN JOURNAL OF BIOTECHNOLOGY
Afr. J. Biotechnol.
volume
10
issue
18
pages
3628 - 3632
Web of Science type
Article
Web of Science id
000290667500019
ISSN
1684-5315
DOI
10.5897/AJB09.1815
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2941773
handle
http://hdl.handle.net/1854/LU-2941773
date created
2012-06-28 14:42:17
date last changed
2012-07-10 08:58:26
@article{2941773,
  abstract     = {Despite a rich tradition of medicinal plants use by local communities in Uganda their direct antimicrobial effectives together with potential to protect human health against diseases induced by oxidative stress are still poorly documented. The aim of this study is to investigate the in vitro antimicrobial and total antioxidative activities of barks from five tree species selected using information on their traditional use by Karamojong healers in Uganda. The antimicrobial activity of crude ethanol extracts of Fagaropsis angolensis (Engl.) H. M. Gardener (Rutaceae), Trichilia prieuriana A. Juss. (Meliaceae), Turraea floribunda Hochst. (Meliaceae), Warburgia salutaris Sprague (Canellaeceae) and Zanthoxylum chalybeum Engl. (Rutaceae) were tested against four bacteria and one yeast species using the broth microdilution method. The total antioxidative activity was determined by 2,2-diphenyl-1-picrylhydrazil free radical scavenging assay. It was found that the extract of F. angolensis possess the strongest antimicrobial activity inhibiting growth of Staphylococcus aureus and Candida albicans with minimum inhibitory concentrations of 64 and 32 mu g/ml, respectively. Among all plants tested, W. salutaris showed the most promising antioxidative properties (IC(50) = 6.59 mu g/ml). As a result of this study, F. angolensis and W. salutaris possessed significant antimicrobial and antioxidative effects which indicates prospective pharmacological properties of both species.},
  author       = {Kuglerova, Marta and Tesarova, Hana and Grade, Jean and Halamova, Katerina and Wanyana-Maganyi, Olivia and Van Damme, Patrick and Kokoska, Ladislav},
  issn         = {1684-5315},
  journal      = {AFRICAN JOURNAL OF BIOTECHNOLOGY},
  keyword      = {UGANDENSIS,PLANTS,SESQUITERPENES,AFRICA,TREE,ANTIMYCOBACTERIAL ACTIVITY,medicinal plants,Uganda,WARBURGIA-SALUTARIS,Antimicrobial activity,total antioxidative activity,crude extracts},
  language     = {eng},
  number       = {18},
  pages        = {3628--3632},
  title        = {Antimicrobial and antioxidative effects of Ugandan medicinal barks},
  url          = {http://dx.doi.org/10.5897/AJB09.1815},
  volume       = {10},
  year         = {2011},
}

Chicago
Kuglerova, Marta, Hana Tesarova, Jean Grade, Katerina Halamova, Olivia Wanyana-Maganyi, Patrick Van Damme, and Ladislav Kokoska. 2011. “Antimicrobial and Antioxidative Effects of Ugandan Medicinal Barks.” African Journal of Biotechnology 10 (18): 3628–3632.
APA
Kuglerova, Marta, Tesarova, H., Grade, J., Halamova, K., Wanyana-Maganyi, O., Van Damme, P., & Kokoska, L. (2011). Antimicrobial and antioxidative effects of Ugandan medicinal barks. AFRICAN JOURNAL OF BIOTECHNOLOGY, 10(18), 3628–3632.
Vancouver
1.
Kuglerova M, Tesarova H, Grade J, Halamova K, Wanyana-Maganyi O, Van Damme P, et al. Antimicrobial and antioxidative effects of Ugandan medicinal barks. AFRICAN JOURNAL OF BIOTECHNOLOGY. 2011;10(18):3628–32.
MLA
Kuglerova, Marta, Hana Tesarova, Jean Grade, et al. “Antimicrobial and Antioxidative Effects of Ugandan Medicinal Barks.” AFRICAN JOURNAL OF BIOTECHNOLOGY 10.18 (2011): 3628–3632. Print.