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Reduced muscle carnosine content in type 2, but not in type 1

Bruno Gualano, Inge Everaert UGent, Sanne Stegen UGent, Guilherme Giannini Artioli, Youri Taes UGent, Hamilton Roschel, Eric Achten UGent, Maria Concepción Otaduy, Antonio Herbert, Jr Lancha and Roger Harris, et al. (2012) AMINO ACIDS. 43(1). p.21-24
abstract
Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (-45%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Skeletal muscle, Glycation, AGEs, Oxidative stress, Diabetic complications, MRS, Carbonyl stress, Beta-alanine, Carnosine
journal title
AMINO ACIDS
Amino Acids
editor
Craig Sale and Wim Derave UGent
volume
43
issue
1
issue title
Carnosine in exercise and disease
pages
21 - 24
Web of Science type
Article
Web of Science id
000305210800004
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
3.914 (2012)
JCR rank
86/288 (2012)
JCR quartile
2 (2012)
ISSN
0939-4451
DOI
10.1007/s00726-011-1165-y
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2940091
handle
http://hdl.handle.net/1854/LU-2940091
date created
2012-06-27 13:58:54
date last changed
2012-09-25 11:13:52
@article{2940091,
  abstract     = {Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (-45\%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle.},
  author       = {Gualano, Bruno and Everaert, Inge and Stegen, Sanne and Artioli, Guilherme Giannini and Taes, Youri and Roschel, Hamilton and Achten, Eric and Otaduy, Maria Concepci{\'o}n and Lancha, Antonio Herbert, Jr and Harris, Roger and Derave, Wim},
  editor       = {Sale, Craig and Derave, Wim},
  issn         = {0939-4451},
  journal      = {AMINO ACIDS},
  keyword      = {Skeletal muscle,Glycation,AGEs,Oxidative stress,Diabetic complications,MRS,Carbonyl stress,Beta-alanine,Carnosine},
  language     = {eng},
  number       = {1},
  pages        = {21--24},
  title        = {Reduced muscle carnosine content in type 2, but not in type 1},
  url          = {http://dx.doi.org/10.1007/s00726-011-1165-y},
  volume       = {43},
  year         = {2012},
}

Chicago
Gualano, Bruno, Inge Everaert, Sanne Stegen, Guilherme Giannini Artioli, Youri Taes, Hamilton Roschel, Eric Achten, et al. 2012. “Reduced Muscle Carnosine Content in Type 2, but Not in Type 1.” Ed. Craig Sale and Wim Derave. Amino Acids 43 (1): 21–24.
APA
Gualano, B., Everaert, I., Stegen, S., Artioli, G. G., Taes, Y., Roschel, H., Achten, E., et al. (2012). Reduced muscle carnosine content in type 2, but not in type 1. (C. Sale & W. Derave, Eds.)AMINO ACIDS, 43(1), 21–24.
Vancouver
1.
Gualano B, Everaert I, Stegen S, Artioli GG, Taes Y, Roschel H, et al. Reduced muscle carnosine content in type 2, but not in type 1. Sale C, Derave W, editors. AMINO ACIDS. 2012;43(1):21–4.
MLA
Gualano, Bruno, Inge Everaert, Sanne Stegen, et al. “Reduced Muscle Carnosine Content in Type 2, but Not in Type 1.” Ed. Craig Sale & Wim Derave. AMINO ACIDS 43.1 (2012): 21–24. Print.