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Reduced muscle carnosine content in type 2, but not in type 1

(2012) AMINO ACIDS. 43(1). p.21-24
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Abstract
Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (-45%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle.
Keywords
Glycation, Skeletal muscle, AGEs, Oxidative stress, Diabetic complications, MRS, Carbonyl stress, Beta-alanine, Carnosine

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Citation

Please use this url to cite or link to this publication:

Chicago
Gualano, Bruno, Inge Everaert, Sanne Stegen, Guilherme Giannini Artioli, Youri Taes, Hamilton Roschel, Eric Achten, et al. 2012. “Reduced Muscle Carnosine Content in Type 2, but Not in Type 1.” Ed. Craig Sale and Wim Derave. Amino Acids 43 (1): 21–24.
APA
Gualano, B., Everaert, I., Stegen, S., Artioli, G. G., Taes, Y., Roschel, H., Achten, E., et al. (2012). Reduced muscle carnosine content in type 2, but not in type 1. (C. Sale & W. Derave, Eds.)AMINO ACIDS, 43(1), 21–24.
Vancouver
1.
Gualano B, Everaert I, Stegen S, Artioli GG, Taes Y, Roschel H, et al. Reduced muscle carnosine content in type 2, but not in type 1. Sale C, Derave W, editors. AMINO ACIDS. 2012;43(1):21–4.
MLA
Gualano, Bruno, Inge Everaert, Sanne Stegen, et al. “Reduced Muscle Carnosine Content in Type 2, but Not in Type 1.” Ed. Craig Sale & Wim Derave. AMINO ACIDS 43.1 (2012): 21–24. Print.
@article{2940091,
  abstract     = {Carnosine is present in high concentrations in skeletal muscle where it contributes to acid buffering and functions also as a natural protector against oxidative and carbonyl stress. Animal studies have shown an anti-diabetic effect of carnosine supplementation. High carnosinase activity, the carnosine degrading enzyme in serum, is a risk factor for diabetic complications in humans. The aim of the present study was to compare the muscle carnosine concentration in diabetic subjects to the level in non-diabetics. Type 1 and 2 diabetic patients and matched healthy controls (total n = 58) were included in the study. Muscle carnosine content was evaluated by proton magnetic resonance spectroscopy (3 Tesla) in soleus and gastrocnemius. Significantly lower carnosine content (-45\%) in gastrocnemius muscle, but not in soleus, was shown in type 2 diabetic patients compared with controls. No differences were observed in type 1 diabetic patients. Type II diabetic patients display a reduced muscular carnosine content. A reduction in muscle carnosine concentration may be partially associated with defective mechanisms against oxidative, glycative and carbonyl stress in muscle.},
  author       = {Gualano, Bruno and Everaert, Inge and Stegen, Sanne and Artioli, Guilherme Giannini and Taes, Youri and Roschel, Hamilton and Achten, Eric and Otaduy, Maria Concepci{\'o}n and Lancha, Antonio Herbert, Jr and Harris, Roger and Derave, Wim},
  editor       = {Sale, Craig and Derave, Wim},
  issn         = {0939-4451},
  journal      = {AMINO ACIDS},
  keyword      = {Glycation,Skeletal muscle,AGEs,Oxidative stress,Diabetic complications,MRS,Carbonyl stress,Beta-alanine,Carnosine},
  language     = {eng},
  number       = {1},
  pages        = {21--24},
  title        = {Reduced muscle carnosine content in type 2, but not in type 1},
  url          = {http://dx.doi.org/10.1007/s00726-011-1165-y},
  volume       = {43},
  year         = {2012},
}

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