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The influence of sex, age and heritability on human skeletal muscle carnosine content

Audrey Baguet UGent, Inge Everaert UGent, Eric Achten UGent, Martine Thomis and Wim Derave UGent (2012) AMINO ACIDS. 43(1). p.13-20
abstract
The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large interindividual differences. Sex and age are determining factors, however, systematic studies investigating the sex effects on muscle carnosine content throughout the human lifespan are lacking. Despite the large inter-individual variation, the intra-individual variation is limited. The question may be asked whether the carnosine content is a muscle characteristic which may be largely genetically determined. A total of 263 healthy male and female subjects of 9–83 years were divided into five different age groups: prepubertal children (PC), adolescents (A), young adults (YA), middle adults (MA) and elderly (E). We included 25 monozygotic and 22 dizygotic twin pairs among the entire study population to study the heritability. The carnosine content was measured non-invasively in the gastrocnemius medialis and soleus by proton magnetic resonance spectroscopy (1H-MRS). In boys, carnosine content was significantly higher (gastrocnemius 22.9%; soleus 44.6%) in A compared to PC, while it did not differ in girls. A decrease (*16%) was observed both in males and females from YA to MA. However, elderly did not have lower carnosine levels in comparison with MA. Higher correlations were found in monozygotic (r = 0.86) compared to dizygotic (r = 0.51) twins, in soleus muscle, but not in gastrocnemius. In conclusion, this study found an effect of puberty on muscle carnosine content in males, but not in females. Muscle carnosine decreased mainly during early adulthood and hardly from adulthood to elderly. High intra-twin correlations were observed, but muscle-dependent differences preclude clear conclusions toward heritability.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
1H-MRS, Muscle carnosine, Heritability, Puberty, Aging
journal title
AMINO ACIDS
Amino Acids
editor
Craig Sale and Wim Derave UGent
volume
43
issue
1
issue title
Carnosine in exercise and disease
pages
13 - 20
Web of Science type
Article
Web of Science id
000305210800003
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
3.914 (2012)
JCR rank
86/288 (2012)
JCR quartile
2 (2012)
ISSN
0939-4451
DOI
10.1007/s00726-011-1197-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2940063
handle
http://hdl.handle.net/1854/LU-2940063
date created
2012-06-27 13:53:28
date last changed
2015-06-17 10:10:11
@article{2940063,
  abstract     = {The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large interindividual differences. Sex and age are determining factors, however, systematic studies investigating the sex effects on muscle carnosine content throughout the human lifespan are lacking. Despite the large inter-individual variation, the intra-individual variation is limited. The question may be asked whether the carnosine content is a muscle characteristic which may be largely genetically determined. A total of 263 healthy male and female subjects of 9--83 years were divided into five different age groups: prepubertal children (PC), adolescents (A), young adults (YA), middle adults (MA) and elderly (E). We included 25 monozygotic and 22 dizygotic twin pairs among the entire study population to study the heritability. The carnosine content was measured non-invasively in the gastrocnemius medialis and soleus by proton magnetic resonance spectroscopy (1H-MRS). In boys, carnosine content was significantly higher (gastrocnemius 22.9\%; soleus 44.6\%) in A compared to PC, while it did not differ in girls. A decrease
(*16\%) was observed both in males and females from YA to MA. However, elderly did not have lower carnosine levels in comparison with MA. Higher correlations were found in monozygotic (r = 0.86) compared to dizygotic (r = 0.51) twins, in soleus muscle, but not in gastrocnemius. In conclusion, this study found an effect of puberty on muscle carnosine content in males, but not in females. Muscle carnosine decreased mainly during early adulthood and hardly from adulthood to elderly. High intra-twin correlations were observed, but muscle-dependent differences preclude clear conclusions toward heritability.},
  author       = {Baguet, Audrey and Everaert, Inge and Achten, Eric and Thomis, Martine and Derave, Wim},
  editor       = {Sale, Craig and Derave, Wim},
  issn         = {0939-4451},
  journal      = {AMINO ACIDS},
  keyword      = {1H-MRS,Muscle carnosine,Heritability,Puberty,Aging},
  language     = {eng},
  number       = {1},
  pages        = {13--20},
  title        = {The influence of sex, age and heritability on human skeletal muscle carnosine content},
  url          = {http://dx.doi.org/10.1007/s00726-011-1197-3},
  volume       = {43},
  year         = {2012},
}

Chicago
Baguet, Audrey, Inge Everaert, Eric Achten, Martine Thomis, and Wim Derave. 2012. “The Influence of Sex, Age and Heritability on Human Skeletal Muscle Carnosine Content.” Ed. Craig Sale and Wim Derave. Amino Acids 43 (1): 13–20.
APA
Baguet, A., Everaert, I., Achten, E., Thomis, M., & Derave, W. (2012). The influence of sex, age and heritability on human skeletal muscle carnosine content. (C. Sale & W. Derave, Eds.)AMINO ACIDS, 43(1), 13–20.
Vancouver
1.
Baguet A, Everaert I, Achten E, Thomis M, Derave W. The influence of sex, age and heritability on human skeletal muscle carnosine content. Sale C, Derave W, editors. AMINO ACIDS. 2012;43(1):13–20.
MLA
Baguet, Audrey, Inge Everaert, Eric Achten, et al. “The Influence of Sex, Age and Heritability on Human Skeletal Muscle Carnosine Content.” Ed. Craig Sale & Wim Derave. AMINO ACIDS 43.1 (2012): 13–20. Print.