Ghent University Academic Bibliography

Advanced

3 T DCE-MRI assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis for treatment response monitoring

Lennart Jans UGent, Tineke De Coninck UGent, RUTH WITTOEK UGent, VALERIE LAMBRECHT UGent, Wouter Huysse UGent, August Verbruggen UGent and Koenraad Verstraete UGent (2013) SKELETAL RADIOLOGY. 42(2). p.255-260
abstract
OBJECTIVE: To study the value of 3 T dynamic contrast-enhanced (DCE)-MRI for assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis (EOA) for treatment response monitoring. MATERIALS AND METHODS: The interphalangeal joints of fingers two to five were examined at 3 T MRI in nine patients with EOA. Two musculoskeletal radiologists recorded erosions, bone marrow oedema (BME), synovitis and osteophytes. Interobserver reliability was calculated using κ statistics. In six patients, DCE-MRI time intensity curves of synovitis in two affected joints were analysed. The maximum upslope, absolute and relative enhancement of synovitis were compared with MRI after 12 months of anti-tumour necrosis factor treatment. Intraobserver reproducibility was calculated using intra-class correlation coefficient. RESULTS: Interobserver reliability was 'good' for detection of erosions (κ = 0.70), BME (κ = 0.77) and synovitis (κ = 0.77), but 'poor' for osteophytes (κ = 0.12). Post-treatment DCE-MRI showed decreasing maximum upslope (p = 0.002) and absolute (p = 0.002) and relative (p = 0.01) enhancement compared to the initial scan. Intraobserver reproducibility of DCE-MRI was 'almost perfect' or 'strong' for all parameters. CONCLUSIONS: 3 T DCE-MRI demonstrates changes in time intensity curves of synovitis in EOA of the interphalangeal joints in a longitudinal study, indicating this technique is promising for monitoring therapy response.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
HAND, MRI, erosive osteoarthritis, synovitis, FINGER JOINTS, MUSCULOSKELETAL LESIONS, RHEUMATOID-ARTHRITIS, FIRST-PASS IMAGES, interphalangeal joint, Dynamic contrast- enhanced, SCORING SYSTEM
journal title
SKELETAL RADIOLOGY
Skeletal Radiol.
volume
42
issue
2
pages
255 - 260
Web of Science type
Article
Web of Science id
000313360600014
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.743 (2013)
JCR rank
58/122 (2013)
JCR quartile
2 (2013)
ISSN
0364-2348
DOI
10.1007/s00256-012-1453-y
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2920024
handle
http://hdl.handle.net/1854/LU-2920024
date created
2012-06-26 12:06:24
date last changed
2015-01-22 09:19:32
@article{2920024,
  abstract     = {OBJECTIVE: To study the value of 3 T dynamic contrast-enhanced (DCE)-MRI for assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis (EOA) for treatment response monitoring.
MATERIALS AND METHODS: The interphalangeal joints of fingers two to five were examined at 3 T MRI in nine patients with EOA. Two musculoskeletal radiologists recorded erosions, bone marrow oedema (BME), synovitis and osteophytes. Interobserver reliability was calculated using \ensuremath{\kappa} statistics. In six patients, DCE-MRI time intensity curves of synovitis in two affected joints were analysed. The maximum upslope, absolute and relative enhancement of synovitis were compared with MRI after 12 months of anti-tumour necrosis factor treatment. Intraobserver reproducibility was calculated using intra-class correlation coefficient.
RESULTS: Interobserver reliability was 'good' for detection of erosions (\ensuremath{\kappa}\,=\,0.70), BME (\ensuremath{\kappa}\,=\,0.77) and synovitis (\ensuremath{\kappa}\,=\,0.77), but 'poor' for osteophytes (\ensuremath{\kappa}\,=\,0.12). Post-treatment DCE-MRI showed decreasing maximum upslope (p\,=\,0.002) and absolute (p\,=\,0.002) and relative (p\,=\,0.01) enhancement compared to the initial scan. Intraobserver reproducibility of DCE-MRI was 'almost perfect' or 'strong' for all parameters.
CONCLUSIONS: 3 T DCE-MRI demonstrates changes in time intensity curves of synovitis in EOA of the interphalangeal joints in a longitudinal study, indicating this technique is promising for monitoring therapy response.},
  author       = {Jans, Lennart and De Coninck, Tineke and WITTOEK, RUTH and LAMBRECHT, VALERIE and Huysse, Wouter and Verbruggen, August and Verstraete, Koenraad},
  issn         = {0364-2348},
  journal      = {SKELETAL RADIOLOGY},
  keyword      = {HAND,MRI,erosive osteoarthritis,synovitis,FINGER JOINTS,MUSCULOSKELETAL LESIONS,RHEUMATOID-ARTHRITIS,FIRST-PASS IMAGES,interphalangeal joint,Dynamic contrast- enhanced,SCORING SYSTEM},
  language     = {eng},
  number       = {2},
  pages        = {255--260},
  title        = {3 T DCE-MRI assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis for treatment response monitoring},
  url          = {http://dx.doi.org/10.1007/s00256-012-1453-y},
  volume       = {42},
  year         = {2013},
}

Chicago
Jans, Lennart, Tineke De Coninck, Ruth Wittoek, Valérie Lambrecht, Wouter Huysse, August Verbruggen, and Koenraad Verstraete. 2013. “3 T DCE-MRI Assessment of Synovitis of the Interphalangeal Joints in Patients with Erosive Osteoarthritis for Treatment Response Monitoring.” Skeletal Radiology 42 (2): 255–260.
APA
Jans, L., De Coninck, T., Wittoek, R., Lambrecht, V., Huysse, W., Verbruggen, A., & Verstraete, K. (2013). 3 T DCE-MRI assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis for treatment response monitoring. SKELETAL RADIOLOGY, 42(2), 255–260.
Vancouver
1.
Jans L, De Coninck T, Wittoek R, Lambrecht V, Huysse W, Verbruggen A, et al. 3 T DCE-MRI assessment of synovitis of the interphalangeal joints in patients with erosive osteoarthritis for treatment response monitoring. SKELETAL RADIOLOGY. 2013;42(2):255–60.
MLA
Jans, Lennart, Tineke De Coninck, Ruth Wittoek, et al. “3 T DCE-MRI Assessment of Synovitis of the Interphalangeal Joints in Patients with Erosive Osteoarthritis for Treatment Response Monitoring.” SKELETAL RADIOLOGY 42.2 (2013): 255–260. Print.