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Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control

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Abstract
Abstract Ion mobility spectrometry (IMS) gains increased pharmaceutical interest as an analytical technique for the verification of equipment cleaning. Using a fractional factorial design, we developed an IMS method for talarozole, which represents a new generation of retinoic acid metabolism blocking agents (RAMBA) that can be used for the treatment of different dermatological diseases, such as psoriasis and acne. Using a Smiths Detection Ionscan-LS and the optimal IMS settings obtained, talarozole showed a drift time of 16.648 ms, corresponding to a reduced ion mobility K0 of 1.072 cm²V−1s−1. Total analysis times below 1 min were achieved. Talarozole was well separated in the plasmagram from other azole compounds and the limit of detection was found to be 43 ng/ml. Swab samples collected from steel and glass plates were successfully analyzed, thereby showing that IMS is indeed a suitable technique for the quantitative analysis of talarozole in cleaning quality control.
Keywords
Cleaning validation, Ion Mobility Spectrometry (IMS), Talarozole (rambazole), Experimental design, Azole drug

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Chicago
Baert, Bram, Jente Boonen, Céline Thierens, and Bart De Spiegeleer. 2011. “Ion Mobility Spectrometry of Talarozole, a New Azole Drug, in Cleaning Quality Control.” International Journal of Ion Mobility Spectrometry 14 (2-3): 109–116.
APA
Baert, Bram, Boonen, J., Thierens, C., & De Spiegeleer, B. (2011). Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control. INTERNATIONAL JOURNAL OF ION MOBILITY SPECTROMETRY, 14(2-3), 109–116.
Vancouver
1.
Baert B, Boonen J, Thierens C, De Spiegeleer B. Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control. INTERNATIONAL JOURNAL OF ION MOBILITY SPECTROMETRY. 2011;14(2-3):109–16.
MLA
Baert, Bram, Jente Boonen, Céline Thierens, et al. “Ion Mobility Spectrometry of Talarozole, a New Azole Drug, in Cleaning Quality Control.” INTERNATIONAL JOURNAL OF ION MOBILITY SPECTROMETRY 14.2-3 (2011): 109–116. Print.
@article{2919785,
  abstract     = {Abstract Ion mobility spectrometry (IMS) gains increased pharmaceutical interest as an analytical technique for the verification of equipment cleaning. Using a fractional factorial design, we developed an IMS method for talarozole, which represents a new generation of retinoic acid metabolism blocking agents (RAMBA) that can be used for the treatment of different dermatological diseases, such as psoriasis and acne. Using a Smiths Detection Ionscan-LS and the optimal IMS settings obtained, talarozole showed a drift time of 16.648 ms, corresponding to a reduced ion mobility K0 of 1.072 cm{\texttwosuperior}V\ensuremath{-}1s\ensuremath{-}1. Total analysis times below 1 min were achieved. Talarozole was well separated in the plasmagram from other azole compounds and the limit of detection was found to be 43 ng/ml. Swab samples collected from steel and glass plates were successfully analyzed, thereby showing that IMS is indeed a suitable technique for the quantitative analysis of talarozole in cleaning quality control.},
  author       = {Baert, Bram and Boonen, Jente and Thierens, C{\'e}line and De Spiegeleer, Bart},
  issn         = {1435-6163},
  journal      = {INTERNATIONAL JOURNAL OF ION MOBILITY SPECTROMETRY},
  language     = {eng},
  number       = {2-3},
  pages        = {109--116},
  title        = {Ion mobility spectrometry of talarozole, a new azole drug, in cleaning quality control},
  url          = {http://dx.doi.org/10.1007/s12127-011-0063-z},
  volume       = {14},
  year         = {2011},
}

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