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Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information

Pieter Mollet (UGent) , Vincent Keereman (UGent) , Enrico Clementel (UGent) and Stefaan Vandenberghe (UGent)
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Abstract
Abstract—Quantitative PET imaging relies on accurate at- tenuation correction. Predicting attenuation values from MR images is difficult because MR signals are related to proton density and relaxation properties of tissues. Here we propose a method to derive the attenuation map from a transmission scan. An annulus transmission source is positioned inside the FOV of the PET scanner. First a blank scan is acquired. The patient is injected with FDG and placed inside the scanner. 511 keV photons coming from the patient and the transmission source are acquired simultaneously. TOF information is used to extract the coincident photons originating from the annulus. The blank and transmission data are compared in an iterative reconstruction method to derive the attenuation map. Simulations with a digital phantom were performed to validate the method. The reconstructed attenuation coefficients differ less than 5% in VOIs inside the lungs, bone and soft tissue. When applying attenuation correction in the reconstruction of the emission data a SUV error smaller than 9% was obtained for all tissues. In conclusion, our method can reconstruct the attenuation map and the emission data from a simultaneous scan without prior knowledge about the anatomy or the attenuation coefficients of the tissues.
Keywords
SCANNER, PET/MRI, IMAGES, CT, PERFORMANCE, SIMULATION, Attenuation correction, positron emission tomography/magnetic resonance imaging (PET/MRI), time-of-flight (TOF), transmission scan, POSITRON TOMOGRAPHY, SINGLE-PHOTON, ITERATIVE RECONSTRUCTION, ATTENUATION CORRECTION

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MLA
Mollet, Pieter, Vincent Keereman, Enrico Clementel, et al. “Simultaneous MR-compatible Emission and Transmission Imaging for PET Using Time-of-flight Information.” IEEE TRANSACTIONS ON MEDICAL IMAGING 31.99 (2012): 1734–1742. Print.
APA
Mollet, P., Keereman, V., Clementel, E., & Vandenberghe, S. (2012). Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information. IEEE TRANSACTIONS ON MEDICAL IMAGING, 31(99), 1734–1742.
Chicago author-date
Mollet, Pieter, Vincent Keereman, Enrico Clementel, and Stefaan Vandenberghe. 2012. “Simultaneous MR-compatible Emission and Transmission Imaging for PET Using Time-of-flight Information.” Ieee Transactions on Medical Imaging 31 (99): 1734–1742.
Chicago author-date (all authors)
Mollet, Pieter, Vincent Keereman, Enrico Clementel, and Stefaan Vandenberghe. 2012. “Simultaneous MR-compatible Emission and Transmission Imaging for PET Using Time-of-flight Information.” Ieee Transactions on Medical Imaging 31 (99): 1734–1742.
Vancouver
1.
Mollet P, Keereman V, Clementel E, Vandenberghe S. Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information. IEEE TRANSACTIONS ON MEDICAL IMAGING. 2012;31(99):1734–42.
IEEE
[1]
P. Mollet, V. Keereman, E. Clementel, and S. Vandenberghe, “Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information,” IEEE TRANSACTIONS ON MEDICAL IMAGING, vol. 31, no. 99, pp. 1734–1742, 2012.
@article{2916429,
  abstract     = {Abstract—Quantitative PET imaging relies on accurate at- tenuation correction. Predicting attenuation values from MR images is difficult because MR signals are related to proton density and relaxation properties of tissues. Here we propose a method to derive the attenuation map from a transmission scan. An annulus transmission source is positioned inside the FOV of the PET scanner. First a blank scan is acquired. The patient is injected with FDG and placed inside the scanner. 511 keV photons coming from the patient and the transmission source are acquired simultaneously. TOF information is used to extract the coincident photons originating from the annulus. The blank and transmission data are compared in an iterative reconstruction method to derive the attenuation map. Simulations with a digital phantom were performed to validate the method. The reconstructed attenuation coefficients differ less than 5% in VOIs inside the lungs, bone and soft tissue. When applying attenuation correction in the reconstruction of the emission data a SUV error smaller than 9% was obtained for all tissues. In conclusion, our method can reconstruct the attenuation map and the emission data from a simultaneous scan without prior knowledge about the anatomy or the attenuation coefficients of the tissues.},
  author       = {Mollet, Pieter and Keereman, Vincent and Clementel, Enrico and Vandenberghe, Stefaan},
  issn         = {0278-0062},
  journal      = {IEEE TRANSACTIONS ON MEDICAL IMAGING},
  keywords     = {SCANNER,PET/MRI,IMAGES,CT,PERFORMANCE,SIMULATION,Attenuation correction,positron emission tomography/magnetic resonance imaging (PET/MRI),time-of-flight (TOF),transmission scan,POSITRON TOMOGRAPHY,SINGLE-PHOTON,ITERATIVE RECONSTRUCTION,ATTENUATION CORRECTION},
  language     = {eng},
  number       = {99},
  pages        = {1734--1742},
  title        = {Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information},
  url          = {http://dx.doi.org/10.1109/TMI.2012.2198831},
  volume       = {31},
  year         = {2012},
}

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