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Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information

Pieter Mollet UGent, Vincent Keereman UGent, Enrico Clementel UGent and Stefaan Vandenberghe UGent (2012) IEEE TRANSACTIONS ON MEDICAL IMAGING. 31(99). p.1734-1742
abstract
Abstract—Quantitative PET imaging relies on accurate at- tenuation correction. Predicting attenuation values from MR images is difficult because MR signals are related to proton density and relaxation properties of tissues. Here we propose a method to derive the attenuation map from a transmission scan. An annulus transmission source is positioned inside the FOV of the PET scanner. First a blank scan is acquired. The patient is injected with FDG and placed inside the scanner. 511 keV photons coming from the patient and the transmission source are acquired simultaneously. TOF information is used to extract the coincident photons originating from the annulus. The blank and transmission data are compared in an iterative reconstruction method to derive the attenuation map. Simulations with a digital phantom were performed to validate the method. The reconstructed attenuation coefficients differ less than 5% in VOIs inside the lungs, bone and soft tissue. When applying attenuation correction in the reconstruction of the emission data a SUV error smaller than 9% was obtained for all tissues. In conclusion, our method can reconstruct the attenuation map and the emission data from a simultaneous scan without prior knowledge about the anatomy or the attenuation coefficients of the tissues.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SCANNER, PET/MRI, IMAGES, CT, PERFORMANCE, SIMULATION, Attenuation correction, positron emission tomography/magnetic resonance imaging (PET/MRI), time-of-flight (TOF), transmission scan, POSITRON TOMOGRAPHY, SINGLE-PHOTON, ITERATIVE RECONSTRUCTION, ATTENUATION CORRECTION
journal title
IEEE TRANSACTIONS ON MEDICAL IMAGING
volume
31
issue
99
pages
1734 - 1742
Web of Science type
Article
Web of Science id
000310148600006
JCR category
ENGINEERING, ELECTRICAL & ELECTRONIC
JCR impact factor
4.027 (2012)
JCR rank
8/242 (2012)
JCR quartile
1 (2012)
ISSN
0278-0062
DOI
10.1109/TMI.2012.2198831
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2916429
handle
http://hdl.handle.net/1854/LU-2916429
date created
2012-06-22 13:02:46
date last changed
2013-10-22 09:17:35
@article{2916429,
  abstract     = {Abstract---Quantitative PET imaging relies on accurate at- tenuation correction. Predicting attenuation values from MR images is difficult because MR signals are related to proton density and relaxation properties of tissues. Here we propose a method to derive the attenuation map from a transmission scan. An annulus transmission source is positioned inside the FOV of the PET scanner. First a blank scan is acquired. The patient is injected with FDG and placed inside the scanner. 511 keV photons coming from the patient and the transmission source are acquired simultaneously. TOF information is used to extract the coincident photons originating from the annulus. The blank and transmission data are compared in an iterative reconstruction method to derive the attenuation map. Simulations with a digital phantom were performed to validate the method. The reconstructed attenuation coefficients differ less than 5\% in VOIs inside the lungs, bone and soft tissue. When applying attenuation correction in the reconstruction of the emission data a SUV error smaller than 9\% was obtained for all tissues. In conclusion, our method can reconstruct the attenuation map and the emission data from a simultaneous scan without prior knowledge about the anatomy or the attenuation coefficients of the tissues.},
  author       = {Mollet, Pieter and Keereman, Vincent and Clementel, Enrico and Vandenberghe, Stefaan},
  issn         = {0278-0062},
  journal      = {IEEE TRANSACTIONS ON MEDICAL IMAGING},
  keyword      = {SCANNER,PET/MRI,IMAGES,CT,PERFORMANCE,SIMULATION,Attenuation correction,positron emission tomography/magnetic resonance imaging (PET/MRI),time-of-flight (TOF),transmission scan,POSITRON TOMOGRAPHY,SINGLE-PHOTON,ITERATIVE RECONSTRUCTION,ATTENUATION CORRECTION},
  language     = {eng},
  number       = {99},
  pages        = {1734--1742},
  title        = {Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information},
  url          = {http://dx.doi.org/10.1109/TMI.2012.2198831},
  volume       = {31},
  year         = {2012},
}

Chicago
Mollet, Pieter, Vincent Keereman, Enrico Clementel, and Stefaan Vandenberghe. 2012. “Simultaneous MR-compatible Emission and Transmission Imaging for PET Using Time-of-flight Information.” Ieee Transactions on Medical Imaging 31 (99): 1734–1742.
APA
Mollet, P., Keereman, V., Clementel, E., & Vandenberghe, S. (2012). Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information. IEEE TRANSACTIONS ON MEDICAL IMAGING, 31(99), 1734–1742.
Vancouver
1.
Mollet P, Keereman V, Clementel E, Vandenberghe S. Simultaneous MR-compatible emission and transmission imaging for PET using time-of-flight information. IEEE TRANSACTIONS ON MEDICAL IMAGING. 2012;31(99):1734–42.
MLA
Mollet, Pieter, Vincent Keereman, Enrico Clementel, et al. “Simultaneous MR-compatible Emission and Transmission Imaging for PET Using Time-of-flight Information.” IEEE TRANSACTIONS ON MEDICAL IMAGING 31.99 (2012): 1734–1742. Print.