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Geometrical calibration and aperture configuration design in multi-pinhole SPECT

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Abstract
A clinical gamma camera can be converted into a high resolution SPECT system for small animal imaging, by replacing the clinical collimator(s) with pinhole collimators. However, for optimal performance, an accurate geometrical calibration is required. If it is assumed that the detector orbit is a true circle, the calibration requires the determination of seven parameters. It has been shown that these can be uniquely determined from a SPECT scan of a phantom consisting of three point sources, if two of the distances between these point sources are known. For multi-pinhole SPECT, two point sources should be sufficient, knowledge of the distance between the point sources is not required. The calibration method has been extended for cases where the orbit deviates from the ideal circle. A second interesting problem in multipinhole SPECT is the optimisation of the collimator design. This requires a measure of image quality, enabling objective comparison between different designs. An efficient analytical method has been developed for that purpose. With this method, it has been shown that the aperture diameter should be slightly smaller than the desired system resolution. We have also found that increased multiplexing (which comes with an apparent increase in system sensitivity) does not lead to reduced variance for a particular target resolution. In practice, avoiding all overlap seems to yield better performance.
Keywords
small animal imaging, RECONSTRUCTION, microSPECT, multiplexing, pinhole SPECT, calibration, LIKELIHOOD, RESOLUTION, SINGLE

Citation

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MLA
Vunckx, K., et al. “Geometrical Calibration and Aperture Configuration Design in Multi-Pinhole SPECT.” IEEE International Symposium on Biomedical Imaging, IEEE, 2008, pp. 1403–06, doi:10.1109/ISBI.2008.4541268.
APA
Vunckx, K., Defrise, M., Beque, D., Vanhove, C., Andreyev, A., & Nuyts, J. (2008). Geometrical calibration and aperture configuration design in multi-pinhole SPECT. IEEE International Symposium on Biomedical Imaging, 1403–1406. https://doi.org/10.1109/ISBI.2008.4541268
Chicago author-date
Vunckx, K, M Defrise, D Beque, Christian Vanhove, A Andreyev, and J Nuyts. 2008. “Geometrical Calibration and Aperture Configuration Design in Multi-Pinhole SPECT.” In IEEE International Symposium on Biomedical Imaging, 1403–6. New York, NY, USA: IEEE. https://doi.org/10.1109/ISBI.2008.4541268.
Chicago author-date (all authors)
Vunckx, K, M Defrise, D Beque, Christian Vanhove, A Andreyev, and J Nuyts. 2008. “Geometrical Calibration and Aperture Configuration Design in Multi-Pinhole SPECT.” In IEEE International Symposium on Biomedical Imaging, 1403–1406. New York, NY, USA: IEEE. doi:10.1109/ISBI.2008.4541268.
Vancouver
1.
Vunckx K, Defrise M, Beque D, Vanhove C, Andreyev A, Nuyts J. Geometrical calibration and aperture configuration design in multi-pinhole SPECT. In: IEEE International Symposium on Biomedical Imaging. New York, NY, USA: IEEE; 2008. p. 1403–6.
IEEE
[1]
K. Vunckx, M. Defrise, D. Beque, C. Vanhove, A. Andreyev, and J. Nuyts, “Geometrical calibration and aperture configuration design in multi-pinhole SPECT,” in IEEE International Symposium on Biomedical Imaging, Paris, France, 2008, pp. 1403–1406.
@inproceedings{2915972,
  abstract     = {{A clinical gamma camera can be converted into a high resolution SPECT system for small animal imaging, by replacing the clinical collimator(s) with pinhole collimators. However, for optimal performance, an accurate geometrical calibration is required. If it is assumed that the detector orbit is a true circle, the calibration requires the determination of seven parameters. It has been shown that these can be uniquely determined from a SPECT scan of a phantom consisting of three point sources, if two of the distances between these point sources are known. For multi-pinhole SPECT, two point sources should be sufficient, knowledge of the distance between the point sources is not required. The calibration method has been extended for cases where the orbit deviates from the ideal circle. A second interesting problem in multipinhole SPECT is the optimisation of the collimator design. This requires a measure of image quality, enabling objective comparison between different designs. An efficient analytical method has been developed for that purpose. With this method, it has been shown that the aperture diameter should be slightly smaller than the desired system resolution. We have also found that increased multiplexing (which comes with an apparent increase in system sensitivity) does not lead to reduced variance for a particular target resolution. In practice, avoiding all overlap seems to yield better performance.}},
  author       = {{Vunckx, K and Defrise, M and Beque, D and Vanhove, Christian and Andreyev, A and Nuyts, J}},
  booktitle    = {{IEEE International Symposium on Biomedical Imaging}},
  isbn         = {{9781424420025}},
  issn         = {{1945-7928}},
  keywords     = {{small animal imaging,RECONSTRUCTION,microSPECT,multiplexing,pinhole SPECT,calibration,LIKELIHOOD,RESOLUTION,SINGLE}},
  language     = {{eng}},
  location     = {{Paris, France}},
  pages        = {{1403--1406}},
  publisher    = {{IEEE}},
  title        = {{Geometrical calibration and aperture configuration design in multi-pinhole SPECT}},
  url          = {{http://doi.org/10.1109/ISBI.2008.4541268}},
  year         = {{2008}},
}

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