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Exosome signaling in mammary gland development and cancer

An Hendrix UGent and Alistair Hume (2011) INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 55(7-9). p.879-887
abstract
Exosomes are 40-100 nm intraluminal vesicles that are released by cells upon fusion of multivesicular endosomes (MVEs) with the plasma membrane. The Rab family of small GTPases, including Rab27A and Rab27B, control different steps of exosome release, including transport of MVEs and docking at the plasma membrane. Exosomes are long range message particles that mediate communication between cells in physiological conditions such as mammary gland development and lactation, but also in pathology such as breast cancer. Metastasis is the culmination of cancer progression and involves a complex interaction with the local and distant environment. Exosome messaging contributes to tumor environment interactions such as immune escape, thrombosis and myofibroblast differentiation, thereby modulating metastatic niche preparation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
breast cancer, exosome, Rab GTPase, metastatic niche, exocytosis, BREAST-CANCER, MULTIVESICULAR ENDOSOMES, VESICLE TRAFFICKING, GENE-EXPRESSION, CARCINOMA CELLS, TUMOR EXOSOMES, MELANOMA-CELLS, LUNG-CANCER, RAB GTPASES, MILK
journal title
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Int. J. Dev. Biol.
volume
55
issue
7-9
issue title
Mammary gland in development and cancer
pages
879 - 887
Web of Science type
Article
Web of Science id
000299655900023
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
2.823 (2011)
JCR rank
19/40 (2011)
JCR quartile
2 (2011)
ISSN
0214-6282
DOI
10.1387/ijdb.113391ah
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2915554
handle
http://hdl.handle.net/1854/LU-2915554
date created
2012-06-22 11:08:31
date last changed
2012-06-25 10:16:09
@article{2915554,
  abstract     = {Exosomes are 40-100 nm intraluminal vesicles that are released by cells upon fusion of multivesicular endosomes (MVEs) with the plasma membrane. The Rab family of small GTPases, including Rab27A and Rab27B, control different steps of exosome release, including transport of MVEs and docking at the plasma membrane. Exosomes are long range message particles that mediate communication between cells in physiological conditions such as mammary gland development and lactation, but also in pathology such as breast cancer. Metastasis is the culmination of cancer progression and involves a complex interaction with the local and distant environment. Exosome messaging contributes to tumor environment interactions such as immune escape, thrombosis and myofibroblast differentiation, thereby modulating metastatic niche preparation.},
  author       = {Hendrix, An and Hume, Alistair},
  issn         = {0214-6282},
  journal      = {INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY},
  keyword      = {breast cancer,exosome,Rab GTPase,metastatic niche,exocytosis,BREAST-CANCER,MULTIVESICULAR ENDOSOMES,VESICLE TRAFFICKING,GENE-EXPRESSION,CARCINOMA CELLS,TUMOR EXOSOMES,MELANOMA-CELLS,LUNG-CANCER,RAB GTPASES,MILK},
  language     = {eng},
  number       = {7-9},
  pages        = {879--887},
  title        = {Exosome signaling in mammary gland development and cancer},
  url          = {http://dx.doi.org/10.1387/ijdb.113391ah},
  volume       = {55},
  year         = {2011},
}

Chicago
Hendrix, An, and Alistair Hume. 2011. “Exosome Signaling in Mammary Gland Development and Cancer.” International Journal of Developmental Biology 55 (7-9): 879–887.
APA
Hendrix, A., & Hume, A. (2011). Exosome signaling in mammary gland development and cancer. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55(7-9), 879–887.
Vancouver
1.
Hendrix A, Hume A. Exosome signaling in mammary gland development and cancer. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2011;55(7-9):879–87.
MLA
Hendrix, An, and Alistair Hume. “Exosome Signaling in Mammary Gland Development and Cancer.” INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 55.7-9 (2011): 879–887. Print.