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Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs

Tim Bosmans (UGent) , Stijn Schauvliege (UGent) , Frank Gasthuys (UGent) , Luc Duchateau (UGent) , Barbara Steblaj, Caroline Gadeyne (UGent) and Ingeborgh Polis (UGent)
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Abstract
Objective : To evaluate the cardiovascular effects of a preload of hydroxyethylstarch 6% (HES), preceding an epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs. Animals : Six female, neutered Beagle dogs (mean 13.3 +/- SD 1.0 kg; 3.6 +/- 0.1 years). Study design : Randomized experimental cross-over study (washout of 1 month). Methods : Anaesthesia was induced with propofol and maintained with isoflurane in oxygen/air. All dogs were anaesthetized twice to receive either treatment HESR (continuous rate infusion [CRI] of 7 mL kg(-1) HES started 30 minutes [T-30] prior to epidural administration of ropivacaine 0.75% 1.65 mg kg(-1) at T0) or treatment R (no HES preload and similar dose and timing of epidural ropivacaine administration). Baseline measurements were obtained at T-5. Heart rate (HR), mean (MAP), diastolic (DAP) and systolic (SAP) invasive arterial pressures, cardiac output (Lithium dilution and pulse contour analysis) and derived parameters were recorded every 5 minutes for 60 minutes. Statistical analysis was performed on five dogs, due to the death of one dog. Results : Clinically relevant decreases in MAP (<60 mmHg) were observed for 20 and 40 minutes following epidural administration in treatments HESR and R respectively. Significant decreases in MAP and DAP were present after treatment HESR for up to 20 minutes following epidural administration. No significant within-treatment and overall differences were observed for other cardiovascular parameters. A transient unilateral Horner's syndrome occurred in two dogs (one in each treatment). One dog died after severe hypotension, associated with epidural anaesthesia. Conclusions and clinical relevance : A CRI of 7 mL kg(-1) HES administered over 30 minutes before epidural treatment did not prevent hypotension induced by epidural ropivacaine 0.75%. Epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs was associated with a high incidence of adverse effects in this study.
Keywords
colloids, cardiovascular, dog, epidural, extradural, preload, ropivacaine, SPINAL-INDUCED HYPOTENSION, ELECTIVE CESAREAN-SECTION, COLLOID PRELOAD, ANAPHYLACTOID REACTIONS, CARDIAC-OUTPUT, CRYSTALLOID PRELOAD, PLASMA SUBSTITUTES, RANDOMIZED-TRIAL, ANESTHESIA, VOLUME

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MLA
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, et al. “Influence of a Preload of Hydroxyethylstarch 6% on the Cardiovascular Effects of Epidural Administration of Ropivacaine 0.75% in Anaesthetized Dogs.” VETERINARY ANAESTHESIA AND ANALGESIA 38.5 (2011): 494–504. Print.
APA
Bosmans, T., Schauvliege, S., Gasthuys, F., Duchateau, L., Steblaj, B., Gadeyne, C., & Polis, I. (2011). Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA, 38(5), 494–504.
Chicago author-date
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Barbara Steblaj, Caroline Gadeyne, and Ingeborgh Polis. 2011. “Influence of a Preload of Hydroxyethylstarch 6% on the Cardiovascular Effects of Epidural Administration of Ropivacaine 0.75% in Anaesthetized Dogs.” Veterinary Anaesthesia and Analgesia 38 (5): 494–504.
Chicago author-date (all authors)
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Barbara Steblaj, Caroline Gadeyne, and Ingeborgh Polis. 2011. “Influence of a Preload of Hydroxyethylstarch 6% on the Cardiovascular Effects of Epidural Administration of Ropivacaine 0.75% in Anaesthetized Dogs.” Veterinary Anaesthesia and Analgesia 38 (5): 494–504.
Vancouver
1.
Bosmans T, Schauvliege S, Gasthuys F, Duchateau L, Steblaj B, Gadeyne C, et al. Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA. 2011;38(5):494–504.
IEEE
[1]
T. Bosmans et al., “Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs,” VETERINARY ANAESTHESIA AND ANALGESIA, vol. 38, no. 5, pp. 494–504, 2011.
@article{2914922,
  abstract     = {Objective : To evaluate the cardiovascular effects of a preload of hydroxyethylstarch 6% (HES), preceding an epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs. 
Animals : Six female, neutered Beagle dogs (mean 13.3 +/- SD 1.0 kg; 3.6 +/- 0.1 years). 
Study design : Randomized experimental cross-over study (washout of 1 month). 
Methods : Anaesthesia was induced with propofol and maintained with isoflurane in oxygen/air. All dogs were anaesthetized twice to receive either treatment HESR (continuous rate infusion [CRI] of 7 mL kg(-1) HES started 30 minutes [T-30] prior to epidural administration of ropivacaine 0.75% 1.65 mg kg(-1) at T0) or treatment R (no HES preload and similar dose and timing of epidural ropivacaine administration). Baseline measurements were obtained at T-5. Heart rate (HR), mean (MAP), diastolic (DAP) and systolic (SAP) invasive arterial pressures, cardiac output (Lithium dilution and pulse contour analysis) and derived parameters were recorded every 5 minutes for 60 minutes. Statistical analysis was performed on five dogs, due to the death of one dog. 
Results : Clinically relevant decreases in MAP (<60 mmHg) were observed for 20 and 40 minutes following epidural administration in treatments HESR and R respectively. Significant decreases in MAP and DAP were present after treatment HESR for up to 20 minutes following epidural administration. No significant within-treatment and overall differences were observed for other cardiovascular parameters. A transient unilateral Horner's syndrome occurred in two dogs (one in each treatment). One dog died after severe hypotension, associated with epidural anaesthesia. 
Conclusions and clinical relevance : A CRI of 7 mL kg(-1) HES administered over 30 minutes before epidural treatment did not prevent hypotension induced by epidural ropivacaine 0.75%. Epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs was associated with a high incidence of adverse effects in this study.},
  author       = {Bosmans, Tim and Schauvliege, Stijn and Gasthuys, Frank and Duchateau, Luc and Steblaj, Barbara and Gadeyne, Caroline and Polis, Ingeborgh},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keywords     = {colloids,cardiovascular,dog,epidural,extradural,preload,ropivacaine,SPINAL-INDUCED HYPOTENSION,ELECTIVE CESAREAN-SECTION,COLLOID PRELOAD,ANAPHYLACTOID REACTIONS,CARDIAC-OUTPUT,CRYSTALLOID PRELOAD,PLASMA SUBSTITUTES,RANDOMIZED-TRIAL,ANESTHESIA,VOLUME},
  language     = {eng},
  number       = {5},
  pages        = {494--504},
  title        = {Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2011.00633.x},
  volume       = {38},
  year         = {2011},
}

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