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Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs

Tim Bosmans UGent, Stijn Schauvliege UGent, Frank Gasthuys UGent, Luc Duchateau UGent, Barbara Steblaj UGent, Caroline Gadeyne UGent and Ingeborgh Polis UGent (2011) VETERINARY ANAESTHESIA AND ANALGESIA. 38(5). p.494-504
abstract
Objective : To evaluate the cardiovascular effects of a preload of hydroxyethylstarch 6% (HES), preceding an epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs. Animals : Six female, neutered Beagle dogs (mean 13.3 +/- SD 1.0 kg; 3.6 +/- 0.1 years). Study design : Randomized experimental cross-over study (washout of 1 month). Methods : Anaesthesia was induced with propofol and maintained with isoflurane in oxygen/air. All dogs were anaesthetized twice to receive either treatment HESR (continuous rate infusion [CRI] of 7 mL kg(-1) HES started 30 minutes [T-30] prior to epidural administration of ropivacaine 0.75% 1.65 mg kg(-1) at T0) or treatment R (no HES preload and similar dose and timing of epidural ropivacaine administration). Baseline measurements were obtained at T-5. Heart rate (HR), mean (MAP), diastolic (DAP) and systolic (SAP) invasive arterial pressures, cardiac output (Lithium dilution and pulse contour analysis) and derived parameters were recorded every 5 minutes for 60 minutes. Statistical analysis was performed on five dogs, due to the death of one dog. Results : Clinically relevant decreases in MAP (<60 mmHg) were observed for 20 and 40 minutes following epidural administration in treatments HESR and R respectively. Significant decreases in MAP and DAP were present after treatment HESR for up to 20 minutes following epidural administration. No significant within-treatment and overall differences were observed for other cardiovascular parameters. A transient unilateral Horner's syndrome occurred in two dogs (one in each treatment). One dog died after severe hypotension, associated with epidural anaesthesia. Conclusions and clinical relevance : A CRI of 7 mL kg(-1) HES administered over 30 minutes before epidural treatment did not prevent hypotension induced by epidural ropivacaine 0.75%. Epidural administration of ropivacaine 0.75% in isoflurane anaesthetized dogs was associated with a high incidence of adverse effects in this study.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
colloids, cardiovascular, dog, epidural, extradural, preload, ropivacaine, SPINAL-INDUCED HYPOTENSION, ELECTIVE CESAREAN-SECTION, COLLOID PRELOAD, ANAPHYLACTOID REACTIONS, CARDIAC-OUTPUT, CRYSTALLOID PRELOAD, PLASMA SUBSTITUTES, RANDOMIZED-TRIAL, ANESTHESIA, VOLUME
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
38
issue
5
pages
494 - 504
Web of Science type
Article
Web of Science id
000293797700011
JCR category
VETERINARY SCIENCES
JCR impact factor
0.944 (2011)
JCR rank
58/141 (2011)
JCR quartile
2 (2011)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2011.00633.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2914922
handle
http://hdl.handle.net/1854/LU-2914922
date created
2012-06-21 14:28:01
date last changed
2012-06-28 16:08:40
@article{2914922,
  abstract     = {Objective : To evaluate the cardiovascular effects of a preload of hydroxyethylstarch 6\% (HES), preceding an epidural administration of ropivacaine 0.75\% in isoflurane anaesthetized dogs. 
Animals : Six female, neutered Beagle dogs (mean 13.3 +/- SD 1.0 kg; 3.6 +/- 0.1 years). 
Study design : Randomized experimental cross-over study (washout of 1 month). 
Methods : Anaesthesia was induced with propofol and maintained with isoflurane in oxygen/air. All dogs were anaesthetized twice to receive either treatment HESR (continuous rate infusion [CRI] of 7 mL kg(-1) HES started 30 minutes [T-30] prior to epidural administration of ropivacaine 0.75\% 1.65 mg kg(-1) at T0) or treatment R (no HES preload and similar dose and timing of epidural ropivacaine administration). Baseline measurements were obtained at T-5. Heart rate (HR), mean (MAP), diastolic (DAP) and systolic (SAP) invasive arterial pressures, cardiac output (Lithium dilution and pulse contour analysis) and derived parameters were recorded every 5 minutes for 60 minutes. Statistical analysis was performed on five dogs, due to the death of one dog. 
Results : Clinically relevant decreases in MAP ({\textlangle}60 mmHg) were observed for 20 and 40 minutes following epidural administration in treatments HESR and R respectively. Significant decreases in MAP and DAP were present after treatment HESR for up to 20 minutes following epidural administration. No significant within-treatment and overall differences were observed for other cardiovascular parameters. A transient unilateral Horner's syndrome occurred in two dogs (one in each treatment). One dog died after severe hypotension, associated with epidural anaesthesia. 
Conclusions and clinical relevance : A CRI of 7 mL kg(-1) HES administered over 30 minutes before epidural treatment did not prevent hypotension induced by epidural ropivacaine 0.75\%. Epidural administration of ropivacaine 0.75\% in isoflurane anaesthetized dogs was associated with a high incidence of adverse effects in this study.},
  author       = {Bosmans, Tim and Schauvliege, Stijn and Gasthuys, Frank and Duchateau, Luc and Steblaj, Barbara and Gadeyne, Caroline and Polis, Ingeborgh},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {colloids,cardiovascular,dog,epidural,extradural,preload,ropivacaine,SPINAL-INDUCED HYPOTENSION,ELECTIVE CESAREAN-SECTION,COLLOID PRELOAD,ANAPHYLACTOID REACTIONS,CARDIAC-OUTPUT,CRYSTALLOID PRELOAD,PLASMA SUBSTITUTES,RANDOMIZED-TRIAL,ANESTHESIA,VOLUME},
  language     = {eng},
  number       = {5},
  pages        = {494--504},
  title        = {Influence of a preload of hydroxyethylstarch 6\% on the cardiovascular effects of epidural administration of ropivacaine 0.75\% in anaesthetized dogs},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2011.00633.x},
  volume       = {38},
  year         = {2011},
}

Chicago
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, Luc Duchateau, Barbara Steblaj, Caroline Gadeyne, and Ingeborgh Polis. 2011. “Influence of a Preload of Hydroxyethylstarch 6% on the Cardiovascular Effects of Epidural Administration of Ropivacaine 0.75% in Anaesthetized Dogs.” Veterinary Anaesthesia and Analgesia 38 (5): 494–504.
APA
Bosmans, T., Schauvliege, S., Gasthuys, F., Duchateau, L., Steblaj, B., Gadeyne, C., & Polis, I. (2011). Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA, 38(5), 494–504.
Vancouver
1.
Bosmans T, Schauvliege S, Gasthuys F, Duchateau L, Steblaj B, Gadeyne C, et al. Influence of a preload of hydroxyethylstarch 6% on the cardiovascular effects of epidural administration of ropivacaine 0.75% in anaesthetized dogs. VETERINARY ANAESTHESIA AND ANALGESIA. 2011;38(5):494–504.
MLA
Bosmans, Tim, Stijn Schauvliege, Frank Gasthuys, et al. “Influence of a Preload of Hydroxyethylstarch 6% on the Cardiovascular Effects of Epidural Administration of Ropivacaine 0.75% in Anaesthetized Dogs.” VETERINARY ANAESTHESIA AND ANALGESIA 38.5 (2011): 494–504. Print.