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Redundancy and rewiring of genetic networks following genome-wide duplication events

Riet De Smet (UGent) and Yves Van de Peer (UGent)
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Abstract
Polyploidy or whole-genome duplication is a frequent phenomenon within the plant kingdom and has been associated with the occurrence of evolutionary novelty and increase in biological complexity. Because genome-wide duplication events duplicate whole molecular networks it is of interest to investigate how these networks evolve subsequent to such events. Although genome duplications are generally followed by massive gene loss, at least part of the network is usually retained in duplicate and can rewire to execute novel functions. Alternatively, the network can remain largely redundant and as such confer robustness against mutations. The increasing availability of high-throughput data makes it possible to study evolution following whole genome duplication events at the network level. Here we discuss how the use of 'omics' data in network analysis can provide novel insights on network redundancy and rewiring and conclude with some directions for future research.
Keywords
ALTERNATIVE SPLICING PATTERNS, FUNCTIONAL DIVERGENCE, EXPRESSION PATTERN, WHOLE-GENOME, TRANSCRIPTION FACTORS, ARABIDOPSIS, POLYPLOIDY, YEAST, METABOLIC NETWORK, EVOLUTION

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MLA
De Smet, Riet, and Yves Van de Peer. “Redundancy and Rewiring of Genetic Networks Following Genome-Wide Duplication Events.” CURRENT OPINION IN PLANT BIOLOGY, vol. 15, no. 2, 2012, pp. 168–76, doi:10.1016/j.pbi.2012.01.003.
APA
De Smet, R., & Van de Peer, Y. (2012). Redundancy and rewiring of genetic networks following genome-wide duplication events. CURRENT OPINION IN PLANT BIOLOGY, 15(2), 168–176. https://doi.org/10.1016/j.pbi.2012.01.003
Chicago author-date
De Smet, Riet, and Yves Van de Peer. 2012. “Redundancy and Rewiring of Genetic Networks Following Genome-Wide Duplication Events.” CURRENT OPINION IN PLANT BIOLOGY 15 (2): 168–76. https://doi.org/10.1016/j.pbi.2012.01.003.
Chicago author-date (all authors)
De Smet, Riet, and Yves Van de Peer. 2012. “Redundancy and Rewiring of Genetic Networks Following Genome-Wide Duplication Events.” CURRENT OPINION IN PLANT BIOLOGY 15 (2): 168–176. doi:10.1016/j.pbi.2012.01.003.
Vancouver
1.
De Smet R, Van de Peer Y. Redundancy and rewiring of genetic networks following genome-wide duplication events. CURRENT OPINION IN PLANT BIOLOGY. 2012;15(2):168–76.
IEEE
[1]
R. De Smet and Y. Van de Peer, “Redundancy and rewiring of genetic networks following genome-wide duplication events,” CURRENT OPINION IN PLANT BIOLOGY, vol. 15, no. 2, pp. 168–176, 2012.
@article{2914633,
  abstract     = {{Polyploidy or whole-genome duplication is a frequent phenomenon within the plant kingdom and has been associated with the occurrence of evolutionary novelty and increase in biological complexity. Because genome-wide duplication events duplicate whole molecular networks it is of interest to investigate how these networks evolve subsequent to such events. Although genome duplications are generally followed by massive gene loss, at least part of the network is usually retained in duplicate and can rewire to execute novel functions. Alternatively, the network can remain largely redundant and as such confer robustness against mutations. The increasing availability of high-throughput data makes it possible to study evolution following whole genome duplication events at the network level. Here we discuss how the use of 'omics' data in network analysis can provide novel insights on network redundancy and rewiring and conclude with some directions for future research.}},
  author       = {{De Smet, Riet and Van de Peer, Yves}},
  issn         = {{1369-5266}},
  journal      = {{CURRENT OPINION IN PLANT BIOLOGY}},
  keywords     = {{ALTERNATIVE SPLICING PATTERNS,FUNCTIONAL DIVERGENCE,EXPRESSION PATTERN,WHOLE-GENOME,TRANSCRIPTION FACTORS,ARABIDOPSIS,POLYPLOIDY,YEAST,METABOLIC NETWORK,EVOLUTION}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{168--176}},
  title        = {{Redundancy and rewiring of genetic networks following genome-wide duplication events}},
  url          = {{http://dx.doi.org/10.1016/j.pbi.2012.01.003}},
  volume       = {{15}},
  year         = {{2012}},
}

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