Ghent University Academic Bibliography

Advanced

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

Richard Jäger, Mathieu Bertrand UGent, Adrienne M Gorman, Peter Vandenabeele UGent and Afshin Samali (2012) BIOLOGY OF THE CELL. 104(5). p.259-270
abstract
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In spite of this, our knowledge of the molecular mechanisms that regulate cell fate following ER stress is limited. The UPR is initiated by three ER transmembrane receptors: PKR-like ER kinase (PERK), activating transcription factor (ATF) 6 and inositol-requiring enzyme 1 (IRE1). These proteins sense the accumulation of unfolded proteins and their activation triggers specific adaptive responses to resolve the stress. Intriguingly, the very same receptors can initiate signalling pathways that lead to apoptosis when the attempts to resolve the ER stress fail. In this review, we describe the known pro-apoptotic signalling pathways emanating from activated PERK, ATF6 and IRE1 and discuss how their signalling switches from an adaptive to a pro-apoptotic response.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
Apoptosis, Endoplasmic reticulum, Unfolded protein response, ACTIVATING TRANSCRIPTION FACTOR-6, ER STRESS, INDUCED APOPTOSIS, TRANSMEMBRANE PROTEIN, MAMMALIAN-CELLS, MESSENGER-RNAS, IRE1 KINASE, ATF6, IRE1-ALPHA, CASPASE-12
journal title
BIOLOGY OF THE CELL
Biol. Cell
volume
104
issue
5
pages
259 - 270
Web of Science type
Review
Web of Science id
000304657100001
JCR category
CELL BIOLOGY
JCR impact factor
3.488 (2012)
JCR rank
82/181 (2012)
JCR quartile
2 (2012)
ISSN
0248-4900
DOI
10.1111/boc.201100055
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2914156
handle
http://hdl.handle.net/1854/LU-2914156
date created
2012-06-21 10:27:16
date last changed
2014-05-12 11:00:40
@article{2914156,
  abstract     = {One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In spite of this, our knowledge of the molecular mechanisms that regulate cell fate following ER stress is limited. The UPR is initiated by three ER transmembrane receptors: PKR-like ER kinase (PERK), activating transcription factor (ATF) 6 and inositol-requiring enzyme 1 (IRE1). These proteins sense the accumulation of unfolded proteins and their activation triggers specific adaptive responses to resolve the stress. Intriguingly, the very same receptors can initiate signalling pathways that lead to apoptosis when the attempts to resolve the ER stress fail. In this review, we describe the known pro-apoptotic signalling pathways emanating from activated PERK, ATF6 and IRE1 and discuss how their signalling switches from an adaptive to a pro-apoptotic response.},
  author       = {J{\"a}ger, Richard and Bertrand, Mathieu and Gorman, Adrienne M and Vandenabeele, Peter and Samali, Afshin},
  issn         = {0248-4900},
  journal      = {BIOLOGY OF THE CELL},
  keyword      = {Apoptosis,Endoplasmic reticulum,Unfolded protein response,ACTIVATING TRANSCRIPTION FACTOR-6,ER STRESS,INDUCED APOPTOSIS,TRANSMEMBRANE PROTEIN,MAMMALIAN-CELLS,MESSENGER-RNAS,IRE1 KINASE,ATF6,IRE1-ALPHA,CASPASE-12},
  language     = {eng},
  number       = {5},
  pages        = {259--270},
  title        = {The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress},
  url          = {http://dx.doi.org/10.1111/boc.201100055},
  volume       = {104},
  year         = {2012},
}

Chicago
Jäger, Richard, Mathieu Bertrand, Adrienne M Gorman, Peter Vandenabeele, and Afshin Samali. 2012. “The Unfolded Protein Response at the Crossroads of Cellular Life and Death During Endoplasmic Reticulum Stress.” Biology of the Cell 104 (5): 259–270.
APA
Jäger, R., Bertrand, M., Gorman, A. M., Vandenabeele, P., & Samali, A. (2012). The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. BIOLOGY OF THE CELL, 104(5), 259–270.
Vancouver
1.
Jäger R, Bertrand M, Gorman AM, Vandenabeele P, Samali A. The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. BIOLOGY OF THE CELL. 2012;104(5):259–70.
MLA
Jäger, Richard, Mathieu Bertrand, Adrienne M Gorman, et al. “The Unfolded Protein Response at the Crossroads of Cellular Life and Death During Endoplasmic Reticulum Stress.” BIOLOGY OF THE CELL 104.5 (2012): 259–270. Print.