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Cerebral oxygen metabolism in patients with progressive supranuclear palsy : a positron emission tomography study

(1997) EUROPEAN NEUROLOGY. 37(1). p.18-22
Author
Organization
Abstract
To investigate cerebral oxygen metabolism in progressive supranuclear palsy (PSP), 5 patients with a clinical diagnosis of PSP and a variable degree of cognitive deficit were selected for positron emission tomography (PET) of the brain. In 4 of them, a significant decrease in oxygen metabolism was found in all cortical regions, without frontal accentuation. In the group as a whole, this decrease was even slightly more marked in parietal and temporal regions. These findings are not consistent with earlier PET studies that demonstrated frontal targeting of hypometabolism in PSP patients. Part of this discrepancy can be explained by differences in methodology, although the use of different clinical criteria and overlap of PSP with other neurodegenerative diseases must be taken into account. It is concluded that the absence of frontal hypometabolism on PET examination does not exclude the diagnosis of PSP.
Keywords
progressive supranuclear palsy, positron emission tomography, frontal hypometabolism, Alzheimer's disease, STEELE-RICHARDSON-OLSZEWSKI, BLOOD-FLOW, PARKINSONS-DISEASE, NATURAL-HISTORY, NORMAL VALUES, BRAIN, HYPOMETABOLISM, PET, DIAGNOSIS, CRITERIA

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Chicago
Santens, Patrick, Jacques De Reuck, Luc Crevits, D Decoo, Ignace Lemahieu, Karel Strijckmans, and Patrick Goethals. 1997. “Cerebral Oxygen Metabolism in Patients with Progressive Supranuclear Palsy : a Positron Emission Tomography Study.” European Neurology 37 (1): 18–22.
APA
Santens, P., De Reuck, J., Crevits, L., Decoo, D., Lemahieu, I., Strijckmans, K., & Goethals, P. (1997). Cerebral oxygen metabolism in patients with progressive supranuclear palsy : a positron emission tomography study. EUROPEAN NEUROLOGY, 37(1), 18–22.
Vancouver
1.
Santens P, De Reuck J, Crevits L, Decoo D, Lemahieu I, Strijckmans K, et al. Cerebral oxygen metabolism in patients with progressive supranuclear palsy : a positron emission tomography study. EUROPEAN NEUROLOGY. 1997;37(1):18–22.
MLA
Santens, Patrick, Jacques De Reuck, Luc Crevits, et al. “Cerebral Oxygen Metabolism in Patients with Progressive Supranuclear Palsy : a Positron Emission Tomography Study.” EUROPEAN NEUROLOGY 37.1 (1997): 18–22. Print.
@article{270941,
  abstract     = {To investigate cerebral oxygen metabolism in progressive supranuclear palsy (PSP), 5 patients with a clinical diagnosis of PSP and a variable degree of cognitive deficit were selected for positron emission tomography (PET) of the brain. In 4 of them, a significant decrease in oxygen metabolism was found in all cortical regions, without frontal accentuation. In the group as a whole, this decrease was even slightly more marked in parietal and temporal regions. These findings are not consistent with earlier PET studies that demonstrated frontal targeting of hypometabolism in PSP patients. Part of this discrepancy can be explained by differences in methodology, although the use of different clinical criteria and overlap of PSP with other neurodegenerative diseases must be taken into account. It is concluded that the absence of frontal hypometabolism on PET examination does not exclude the diagnosis of PSP.},
  author       = {Santens, Patrick and De Reuck, Jacques and Crevits, Luc and Decoo, D and Lemahieu, Ignace and Strijckmans, Karel and Goethals, Patrick},
  issn         = {0014-3022},
  journal      = {EUROPEAN NEUROLOGY},
  keyword      = {progressive supranuclear palsy,positron emission tomography,frontal hypometabolism,Alzheimer's disease,STEELE-RICHARDSON-OLSZEWSKI,BLOOD-FLOW,PARKINSONS-DISEASE,NATURAL-HISTORY,NORMAL VALUES,BRAIN,HYPOMETABOLISM,PET,DIAGNOSIS,CRITERIA},
  language     = {eng},
  number       = {1},
  pages        = {18--22},
  title        = {Cerebral oxygen metabolism in patients with progressive supranuclear palsy : a positron emission tomography study},
  url          = {http://dx.doi.org/10.1159/000117398},
  volume       = {37},
  year         = {1997},
}

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